CHOLESTENOT

Study of the molecular events induced by specific functional foods with a double targeting to effectively reduce cholesterol levels

Coordinatore	UNIVERSIDAD AUTONOMA DE MADRID    more  Organization address address: CALLE EINSTEIN, CIUDAD UNIV CANTOBLANCO RECTORADO 3 city: MADRID postcode: 28049 contact info Titolo: Ms. Nome: Ana Cognome: Amigo Email: send email Telefono: +34 91 497 2897 Fax: 34-914972978
Nazionalità Coordinatore	Spain [ES]
Totale costo	161˙293 €
EC contributo	161˙293 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IIF
Funding Scheme	MC-IIF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-15   -   2012-09-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSIDAD AUTONOMA DE MADRID  Organization address address: CALLE EINSTEIN, CIUDAD UNIV CANTOBLANCO RECTORADO 3 city: MADRID postcode: 28049 contact info Titolo: Ms. Nome: Ana Cognome: Amigo Email: send email Telefono: +34 91 497 2897 Fax: 34-914972978	ES (MADRID)	coordinator	161˙293.00

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 Obiettivo del progetto (Objective)

'This proposal is focused on the development of a meat-based functional food (pâté, sausage, snacks etc.) able to effectively reduce cholesterol levels in serum by acting simultaneously at two different levels: (I) reducing endogenous cholesterol synthesis by inhibiting the hydroxymethylglutaryl-CoA reductase (the key enzyme in the cholesterol metabolism) and (II) impairing exogenous cholesterol absorption during digestion by its displacement from the dietary mixed micelles and binding of bile acids during the intestinal digestion to avoid their reabsorption. Edible mushrooms will be submitted to accelerate solvent extraction (ASE) and supercritical fluid extraction (SFE) to obtain (T1) polysaccharides (b-glucans), (T2) statin-like or other metabolites and (T3) ergosterol-derivatives concentrates. These concentrates and their mixtures (T1T2T3 in a meat-based food matrix) will be screened for their properties to act as (I) and (II). All samples will be submitted to in vitro digestion and absorption tests (using Caco2 cell models) to study their bioavailability and molecular mechanism of action. Responsible compounds will be identified and quantified by analytical standardized tools (HPLC-, GC-MS etc)'