GS2DS
Systematic Analysis of Gene Synergies to Discover Drug Synergies
| Coordinatore | Sabanci University
Organization address
address: Orhanli Tuzla contact info |
| Nazionalità Coordinatore | Turkey [TR] |
| Totale costo | 75˙000 € |
| EC contributo | 75˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2010-RG |
| Funding Scheme | MC-IRG |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-09-01 - 2013-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
Sabanci University
Organization address
address: Orhanli Tuzla contact info |
TR (ISTANBUL) | coordinator | 75˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'Using multitherapeutics against disease is a promising direction in medicine. A particularly useful drug combination is a synergistic drug pair, where two drugs administered together produce a collective effect better than the added independent effects of both. Since drug interaction screening is an expensive experiment, most synergistic drug pairs are found by serendipity. In this proposal, we describe a research plan which aims to develop predictive tools for drug synergy. During the proposed research, drug pairs with synergistic antifungal activity will be discovered. A preliminary study has shown that these predictive tools are likely to succeed. The results of the proposed research will lead to a better understanding of drug interactions and their potential in medicine.'
Introduzione (Teaser)
Using synergistic drug interactions allows physicians to decrease individual drug doses while achieving full therapeutic effect. It is important to predict possible drug synergies in order to decrease drug toxicity and reduce the side effects.