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SYNFLOW

Innovative Synthesis in Continuous-Flow Processes for Sustainable Chemical Production

Coordinatore	RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Organization address address: Templergraben 55 city: AACHEN postcode: 52062 contact info Titolo: Prof. Nome: Ernst Cognome: Schmachtenberg Email: send email Telefono: +49 241 80 90490 Fax: +49 241 80 92490
Nazionalità Coordinatore	Germany [DE]
Sito del progetto	http://www.synflow.eu
Totale costo	15˙990˙878 €
EC contributo	10˙978˙076 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2009-LARGE-3
Funding Scheme	CP-IP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-01 - 2014-08-31

Partecipanti

#	participant	country	role	EC contrib. [€]
1	RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Organization address address: Templergraben 55 city: AACHEN postcode: 52062 contact info Titolo: Prof. Nome: Ernst Cognome: Schmachtenberg Email: send email Telefono: +49 241 80 90490 Fax: +49 241 80 92490	DE (AACHEN)	coordinator	1˙932˙947.50
2	EVONIK INDUSTRIES AG Organization address address: RELLINGHAUSER STRASSE 1-11 city: ESSEN postcode: 45128 contact info Titolo: Mr. Nome: Alexander Cognome: Sauer Email: send email Telefono: +49 6181 59 5148	DE (ESSEN)	participant	797˙346.00
3	THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS Organization address address: NORTH STREET 66 COLLEGE GATE city: ST ANDREWS FIFE postcode: KY16 9AJ contact info Titolo: Dr. Nome: Alisdair Cognome: Gibson Email: send email Telefono: 441334000000 Fax: 441334000000	UK (ST ANDREWS FIFE)	participant	785˙770.00
4	FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN NURNBERG Organization address address: SCHLOSSPLATZ 4 city: ERLANGEN postcode: 91054 contact info Titolo: Ms. Nome: Ulrike Cognome: Hermann Email: send email Telefono: +49 9131 852 4043 Fax: +49 9131 852 6239	DE (ERLANGEN)	participant	743˙480.00
5	INVITE GMBH Organization address address: KAISER WILHELM ALLEE city: LEVERKUSEN postcode: 51373 contact info Titolo: Dr. Nome: Thomas Cognome: Bieringer Email: send email Telefono: +49 214 31203101	DE (LEVERKUSEN)	participant	589˙750.00
6	BAYER TECHNOLOGY SERVICES GMBH Organization address address: Kaiser-Wilhelm-Allee city: LEVERKUSEN postcode: 51368 contact info Titolo: Mr. Nome: Klaus-Jürgen Cognome: Maharowski Email: send email Telefono: +49 214 30 39098 Fax: +49 214 30 35865	DE (LEVERKUSEN)	participant	589˙056.00
7	BRITEST LBG Organization address address: Garsington Road Oxford Business Park city: OXFORD postcode: OX4 2HN contact info Titolo: Mrs. Nome: Sue Cognome: Fleet Email: send email Telefono: +44 1928 515683 Fax: +44 1928 515677	UK (OXFORD)	participant	556˙800.00
8	THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD contact info Titolo: Mr. Nome: Paul Cognome: Cartledge Email: send email Telefono: +44 115 9515 679 Fax: +44 115 9513 633	UK (NOTTINGHAM)	participant	538˙351.00
9	DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V. Organization address address: Theodor-Heuss-Allee 25 city: FRANKFURT postcode: 60486 contact info Titolo: Ms. Nome: Roberta Cognome: Jablonski Email: send email Telefono: +49 69 7564 357 Fax: +49 69 7564 257	DE (FRANKFURT)	participant	531˙348.00
10	DANMARKS TEKNISKE UNIVERSITET Organization address address: Anker Engelundsvej 1, Building 101A city: KONGENS LYNGBY postcode: 2800 contact info Titolo: Prof. Nome: Rasmus Cognome: Fehrmann Email: send email Telefono: +45 4525 2389 Fax: +45 45883136	DK (KONGENS LYNGBY)	participant	462˙660.00
11	UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II. Organization address address: Corso Umberto I 40 city: NAPOLI postcode: 80138 contact info Titolo: Prof. Nome: Nino Cognome: Grizzuti Email: send email Telefono: +39 081 7682285 Fax: +39 081 2391800	IT (NAPOLI)	participant	450˙800.00
12	ASTRAZENECA UK LIMITED Organization address address: STANHOPE GATE 15 city: LONDON postcode: W1K 1LN contact info Titolo: Dr. Nome: Hans-Jürgen Cognome: Federsel Email: send email Telefono: +46 8 55327063 Fax: +46 8 55324276	UK (LONDON)	participant	423˙151.00
13	UNIVERSITAT ROVIRA I VIRGILI Organization address address: CARRER DE ESCORXADOR city: TARRAGONA postcode: 43003 contact info Titolo: Prof. Nome: Carmen Cognome: Claver Email: send email Telefono: +34 977 559574	ES (TARRAGONA)	participant	371˙984.00
14	UNIVERSITATEA DIN BUCURESTI Organization address address: MIHAIL KOGALNICEANU STREET 36-46 SECTOR V city: BUCURESTI postcode: 50107 contact info Titolo: Prof. Nome: Vasile Cognome: Parvulescu Email: send email Telefono: +40 21 4100241 Fax: +40 21 4100241	RO (BUCURESTI)	participant	363˙000.00
15	THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House - city: COVENTRY postcode: CV4 8UW contact info Titolo: Dr. Nome: Peter Cognome: Hedges Email: send email Telefono: +44 247 652 3716 Fax: +44 247 652 4991	UK (COVENTRY)	participant	287˙822.00
16	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543	UK (CAMBRIDGE)	participant	279˙221.00
17	UPPSALA UNIVERSITET Organization address address: SANKT OLOFSGATAN 10 B city: UPPSALA postcode: 751 05 contact info Titolo: Prof. Nome: Pher G. Cognome: Andersson Email: send email Telefono: +46 18 471 3801 Fax: +46 18 471 3818	SE (UPPSALA)	participant	263˙958.00
18	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Armelle Cognome: Barelli Email: send email Telefono: +33 5 61 33 60 80 Fax: +33 5 62 17 29 01	FR (PARIS)	participant	250˙228.00
19	JOHNSON MATTHEY PLC. Organization address address: FARRINGDON STREET 25 - 5th floor city: LONDON postcode: EC4A 4AB contact info Titolo: Mr. Nome: Alan Cognome: Herbert Email: send email Telefono: +44 118 9242126 Fax: +44 1189 242306	UK (LONDON)	participant	218˙321.50
20	GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Dr. Nome: Ludde Cognome: Edgren Email: send email Telefono: +46 31 7862783 Fax: +46 31 7864355	SE (GOETEBORG)	participant	210˙840.00
21	UNIVERSITE DE RENNES I Organization address address: RUE DU THABOR 2 city: RENNES CEDEX postcode: 35065 contact info Titolo: Ms. Nome: Yolaine Cognome: Bompays Email: send email Telefono: +33 2 23 23 37 23 Fax: +33 2 23 23 58 76	FR (RENNES CEDEX)	participant	191˙200.00
22	STOCKHOLMS UNIVERSITET Organization address address: Universitetsvaegen 10 city: STOCKHOLM postcode: 10691 contact info Titolo: Prof. Nome: Pher Cognome: Andersson Email: send email Telefono: +46 8162720	SE (STOCKHOLM)	participant	140˙042.00
23	Evonik Oxeno GmbH Organization address city: Marl postcode: 45772 contact info Titolo: Dr. Nome: Dietrich Cognome: Maschmeyer Email: send email Telefono: +49 2365 49 4961 Fax: +49 2365 49 804961	DE (Marl)	participant	0.00

Mappa

Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

continuous shift chemicals synthesis chemical pharmaceuticals academic superior sustainable catalytic represented molecular fine comprising performance methodology demonstrated industries medium operations reactor inefficient engineering separate technologies flow batch flexible synflow vision wise industrial catalyst intermediates conceptual reaction pharmaceutical

Obiettivo del progetto (Objective)

'The SYNFLOW vision is the paradigm shift from batch-wise large volume processes in pharmaceuticals, fine chemicals and intermediates production comprising many separate unit operations towards highly integrated but yet flexible catalytic continuous flow processing. For this purpose, SYNFLOW develops a unique integrative approach combining molecular understanding of synthesis and catalysis with engineering science in process design and plant concepts, aiming at an efficiency breakthrough in process development and operation. The SYNFLOW mission is to overcome the traditional way of linear process development providing individual solutions for specific products, and to demonstrate the technological, economic and ecological superiority of truly „designing“ processes by application of advanced chemical and engineering knowledge. The SYNFLOW concept is based on the definition of generic challenges with industrial relevance, represented by Case Studies provided by the industrial consortium members. Catalyst development, studies of the underlying chemical target transformations (synthetic methodology), tailored reaction engineering, conceptual process design and process evaluation interact closely in order to substantiate the SYNFLOW vision. Its success will be demonstrated on a relevant production scale as a reference for the entire European Chemical Industry. The SYNFLOW consortium brings together major industrial producers from the Pharmaceuticals, Fine Chemicals and Intermediates sectors, providers of process technology and technical catalyst supply. A number of high-ranked academic partners ensures the availability of comprehensive expertise for the suggested Case Studies. Dissemination of the results is guaranteed by the participation of DECHEMA and Britest. SYNFLOW presents a holistic approach to central challenges of the European Chemical Industries and therefore a highly promising candidate to fulfill the crucial issues of the NMP-2009-3.2-1 call.'

Introduzione (Teaser)

Traditional industrial-scale chemical production is inefficient and unsuitable for the flexible and sustainable production of chemicals. An EU-funded project worked to develop integrated catalytic continuous flow processes for low-to-medium-scale chemical production.

Descrizione progetto (Article)

In ideal continuous flow processes, the substrates flow into the reactor and come in contact with the immobilised catalyst to undergo a chemical transformation. The resulting product then leaves the reactor in a pure form, ready for further use without the need for additional separation or purification steps.

To achieve this ambitious goal, a team of 13 academic and 6 industrial partners from all over Europe collaborated in the project http://www.synflow.eu (SYNFLOW) (Innovative synthesis in continuous-flow processes for sustainable chemical production). They integrated molecular catalysts, immobilisation strategies and reaction engineering.

The project developed a basis for new and widely applicable sustainable technologies for low-to-medium-scale chemical and pharmaceutical production. The vision of SYNFLOW was to realise a shift from batch-wise processes comprising many separate unit operations to highly integrated and flexible catalytic continuous flow processing.

Scientists successfully demonstrated the concept of catalytic process design. Continuous flow processes resulted in superior performance, advantageous for small-to-medium-scale chemical and pharmaceutical manufacturing. Sustainable process design methodology was based on experimental results and conceptual insight.

The project targeted fine and specialty chemicals and pharmaceutical industries, which are characterised by a large diversity of synthesised chemical structures. To demonstrate the broad impact of the SYNFLOW concept, the prototypical case studies served as examples for generic challenges in these fields.

Project partners performed six industrial case studies, defined by certain industrial partners. The case studies represented reaction types such as C-N and C-C bond formation and stoichiometric reductions, notorious for waste generation and inefficient resource and energy utilisation.

SYNFLOW provided guidelines on the commercial viability, safety, eco-friendliness and performance of the project's technologies. Demonstrated evidence for superior process performance provides distinct potential business advantages of continuous flow processes.