SYNFLOW
Innovative Synthesis in Continuous-Flow Processes for Sustainable Chemical Production
| Coordinatore | RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Organization address
address: Templergraben 55 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.synflow.eu |
| Totale costo | 15˙990˙878 € |
| EC contributo | 10˙978˙076 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2009-LARGE-3 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-09-01 - 2014-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Organization address
address: Templergraben 55 contact info |
DE (AACHEN) | coordinator | 1˙932˙947.50 |
| 2 |
EVONIK INDUSTRIES AG
Organization address
address: RELLINGHAUSER STRASSE 1-11 contact info |
DE (ESSEN) | participant | 797˙346.00 |
| 3 |
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
Organization address
address: NORTH STREET 66 COLLEGE GATE contact info |
UK (ST ANDREWS FIFE) | participant | 785˙770.00 |
| 4 |
FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN NURNBERG
Organization address
address: SCHLOSSPLATZ 4 contact info |
DE (ERLANGEN) | participant | 743˙480.00 |
| 5 |
INVITE GMBH
Organization address
address: KAISER WILHELM ALLEE contact info |
DE (LEVERKUSEN) | participant | 589˙750.00 |
| 6 |
BAYER TECHNOLOGY SERVICES GMBH
Organization address
address: Kaiser-Wilhelm-Allee contact info |
DE (LEVERKUSEN) | participant | 589˙056.00 |
| 7 |
BRITEST LBG
Organization address
address: Garsington Road Oxford Business Park contact info |
UK (OXFORD) | participant | 556˙800.00 |
| 8 |
THE UNIVERSITY OF NOTTINGHAM
Organization address
address: University Park contact info |
UK (NOTTINGHAM) | participant | 538˙351.00 |
| 9 |
DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V.
Organization address
address: Theodor-Heuss-Allee 25 contact info |
DE (FRANKFURT) | participant | 531˙348.00 |
| 10 |
DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
DK (KONGENS LYNGBY) | participant | 462˙660.00 |
| 11 |
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.
Organization address
address: Corso Umberto I 40 contact info |
IT (NAPOLI) | participant | 450˙800.00 |
| 12 |
ASTRAZENECA UK LIMITED
Organization address
address: STANHOPE GATE 15 contact info |
UK (LONDON) | participant | 423˙151.00 |
| 13 |
UNIVERSITAT ROVIRA I VIRGILI
Organization address
address: CARRER DE ESCORXADOR contact info |
ES (TARRAGONA) | participant | 371˙984.00 |
| 14 |
UNIVERSITATEA DIN BUCURESTI
Organization address
address: MIHAIL KOGALNICEANU STREET 36-46 SECTOR V contact info |
RO (BUCURESTI) | participant | 363˙000.00 |
| 15 |
THE UNIVERSITY OF WARWICK
Organization address
address: Kirby Corner Road - University House - contact info |
UK (COVENTRY) | participant | 287˙822.00 |
| 16 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 279˙221.00 |
| 17 |
UPPSALA UNIVERSITET
Organization address
address: SANKT OLOFSGATAN 10 B contact info |
SE (UPPSALA) | participant | 263˙958.00 |
| 18 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 250˙228.00 |
| 19 |
JOHNSON MATTHEY PLC.
Organization address
address: FARRINGDON STREET 25 - 5th floor contact info |
UK (LONDON) | participant | 218˙321.50 |
| 20 |
GOETEBORGS UNIVERSITET
Organization address
address: VASAPARKEN contact info |
SE (GOETEBORG) | participant | 210˙840.00 |
| 21 |
UNIVERSITE DE RENNES I
Organization address
address: RUE DU THABOR 2 contact info |
FR (RENNES CEDEX) | participant | 191˙200.00 |
| 22 |
STOCKHOLMS UNIVERSITET
Organization address
address: Universitetsvaegen 10 contact info |
SE (STOCKHOLM) | participant | 140˙042.00 |
| 23 |
Evonik Oxeno GmbH
Organization address
city: Marl contact info |
DE (Marl) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'The SYNFLOW vision is the paradigm shift from batch-wise large volume processes in pharmaceuticals, fine chemicals and intermediates production comprising many separate unit operations towards highly integrated but yet flexible catalytic continuous flow processing. For this purpose, SYNFLOW develops a unique integrative approach combining molecular understanding of synthesis and catalysis with engineering science in process design and plant concepts, aiming at an efficiency breakthrough in process development and operation. The SYNFLOW mission is to overcome the traditional way of linear process development providing individual solutions for specific products, and to demonstrate the technological, economic and ecological superiority of truly „designing“ processes by application of advanced chemical and engineering knowledge. The SYNFLOW concept is based on the definition of generic challenges with industrial relevance, represented by Case Studies provided by the industrial consortium members. Catalyst development, studies of the underlying chemical target transformations (synthetic methodology), tailored reaction engineering, conceptual process design and process evaluation interact closely in order to substantiate the SYNFLOW vision. Its success will be demonstrated on a relevant production scale as a reference for the entire European Chemical Industry. The SYNFLOW consortium brings together major industrial producers from the Pharmaceuticals, Fine Chemicals and Intermediates sectors, providers of process technology and technical catalyst supply. A number of high-ranked academic partners ensures the availability of comprehensive expertise for the suggested Case Studies. Dissemination of the results is guaranteed by the participation of DECHEMA and Britest. SYNFLOW presents a holistic approach to central challenges of the European Chemical Industries and therefore a highly promising candidate to fulfill the crucial issues of the NMP-2009-3.2-1 call.'
Introduzione (Teaser)
Traditional industrial-scale chemical production is inefficient and unsuitable for the flexible and sustainable production of chemicals. An EU-funded project worked to develop integrated catalytic continuous flow processes for low-to-medium-scale chemical production.
Descrizione progetto (Article)
In ideal continuous flow processes, the substrates flow into the reactor and come in contact with the immobilised catalyst to undergo a chemical transformation. The resulting product then leaves the reactor in a pure form, ready for further use without the need for additional separation or purification steps.
To achieve this ambitious goal, a team of 13 academic and 6 industrial partners from all over Europe collaborated in the project http://www.synflow.eu (SYNFLOW) (Innovative synthesis in continuous-flow processes for sustainable chemical production). They integrated molecular catalysts, immobilisation strategies and reaction engineering.
The project developed a basis for new and widely applicable sustainable technologies for low-to-medium-scale chemical and pharmaceutical production. The vision of SYNFLOW was to realise a shift from batch-wise processes comprising many separate unit operations to highly integrated and flexible catalytic continuous flow processing.
Scientists successfully demonstrated the concept of catalytic process design. Continuous flow processes resulted in superior performance, advantageous for small-to-medium-scale chemical and pharmaceutical manufacturing. Sustainable process design methodology was based on experimental results and conceptual insight.
The project targeted fine and specialty chemicals and pharmaceutical industries, which are characterised by a large diversity of synthesised chemical structures. To demonstrate the broad impact of the SYNFLOW concept, the prototypical case studies served as examples for generic challenges in these fields.
Project partners performed six industrial case studies, defined by certain industrial partners. The case studies represented reaction types such as C-N and C-C bond formation and stoichiometric reductions, notorious for waste generation and inefficient resource and energy utilisation.
SYNFLOW provided guidelines on the commercial viability, safety, eco-friendliness and performance of the project's technologies. Demonstrated evidence for superior process performance provides distinct potential business advantages of continuous flow processes.