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MEDALL

Mechanisms of the Development of ALLergy

Coordinatore	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Audrey Cognome: Laurent Email: send email Telefono: +331 49 59 56 76 Fax: +33 1 49 59 18 20
Nazionalità Coordinatore	France [FR]
Sito del progetto	http://www.medall-fp7.eu
Totale costo	15˙659˙041 €
EC contributo	11˙990˙939 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2010-single-stage
Funding Scheme	CP-IP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-12-01 - 2015-05-31

Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Audrey Cognome: Laurent Email: send email Telefono: +331 49 59 56 76 Fax: +33 1 49 59 18 20	FR (PARIS)	coordinator	658˙597.20
2	ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: Hanzeplein 1 city: GRONINGEN postcode: 9713 GZ contact info Titolo: Mr. Nome: J.M. Cognome: Van Apeldoorn Email: send email Telefono: 31503633040 Fax: +31 50 3611479	NL (GRONINGEN)	participant	1˙896˙840.00
3	FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL Organization address address: Calle Doctor Aiguader 88 city: BARCELONA postcode: 8003 contact info Titolo: Ms. Nome: Gemma Cognome: Perello Email: send email Telefono: +34 93 214 73 70 Fax: +34 93 214 73 02	ES (BARCELONA)	participant	1˙493˙456.00
4	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Mr. Nome: Ludovic Cognome: Hamon Email: send email Telefono: 33142349501 Fax: 33142349508	FR (PARIS)	participant	1˙380˙930.00
5	INSERM - TRANSFERT SA Organization address address: Rue Watt 7 city: PARIS postcode: 75013 contact info Titolo: Mr. Nome: Louis Cognome: Jammayrac Email: send email Telefono: +33 1 55 03 01 01 Fax: +33 1 55 03 01 60	FR (PARIS)	participant	823˙681.00
6	MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Rudolf Cognome: Valenta Email: send email Telefono: 431404000000 Fax: 431404000000	AT (WIEN)	participant	746˙461.60
7	SCHWEIZERISCHES FORSCHUNGSINSTITUT FUER HOCHGEBIRGSKLIMA UND MEDIZIN IN DAVOS Organization address address: Promenade 35 city: DAVOS PLATZ postcode: 7270 contact info Titolo: Ms. Nome: Daniela Cognome: Bert Email: send email Telefono: +41 81 410 08 48 Fax: +41 81 410 08 40	CH (DAVOS PLATZ)	participant	729˙630.40
8	UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 contact info Titolo: Dr. Nome: Margo Cognome: Baele Email: send email Telefono: 3292643106 Fax: 3292643029	BE (GENT)	participant	613˙643.00
9	BIOMAX INFORMATICS AG Organization address address: ROBERT KOCH STRASSE 2 city: PLANEGG postcode: 82152 contact info Titolo: Dr. Nome: Dieter Cognome: Maier Email: send email Telefono: +49 89 89 55 74 826 Fax: +49 89 89 55 74 825	DE (PLANEGG)	participant	597˙365.00
10	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Juergen Cognome: Ertel Email: send email Telefono: 498932000000 Fax: 498932000000	DE (MUENCHEN)	participant	568˙260.25
11	CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 contact info Titolo: Prof. Nome: Eveline Cognome: Fräßdorf Email: send email Telefono: 4930450000000 Fax: 4930450000000	DE (BERLIN)	participant	517˙553.00
12	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Dr. Nome: Miles Cognome: Davies Email: send email Telefono: +46 8 52486593 Fax: +46 8 310343	SE (STOCKHOLM)	participant	341˙550.00
13	UNIVERSITEIT UTRECHT Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Ms. Nome: Monique Cognome: Van Der Hoek Email: send email Telefono: +31 30 2533566 Fax: +31 30 2533566	NL (UTRECHT)	participant	292˙051.00
14	UNIVERSITETET I OSLO Organization address address: Problemveien 5-7 city: OSLO postcode: 313 contact info Titolo: Ms. Nome: Randi Cognome: Stene Email: send email Telefono: +4722 84 46 54 Fax: +47988 01 538	NO (OSLO)	participant	287˙095.00
15	BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST Organization address address: Duckworth Lane city: Bradford postcode: BD9 6RJ contact info Titolo: Mr. Nome: Alec Cognome: Cowell Email: send email Telefono: +44 1274 364403 Fax: +44 1274 382640	UK (Bradford)	participant	249˙846.30
16	"onmedic Networks, S.L" Organization address address: Balmes 30 city: Barcelona postcode: 8007 contact info Titolo: Ms. Nome: Cristina Cognome: Sanchez Garrido Email: send email Telefono: +34 932720044 Fax: 34933184258	ES (Barcelona)	participant	194˙153.40
17	Nome Ente NON disponibile Organization address address: STENBACKINKATU 9 city: HELSINKI postcode: 29 contact info Titolo: Ms. Nome: Merja Cognome: Takala Email: send email Telefono: +358 9 471 72023 Fax: +358 9 471 75404	FI (HELSINKI)	participant	183˙086.40
18	AZIENDA SANITARIA LOCALE ROMA Organization address address: Borgo Santo Spirito 3 city: ROMA postcode: 198 contact info Titolo: Ms. Nome: Mirella Cognome: Salatino Email: send email Telefono: +39 06 83060 487 Fax: +39 06 83060 374	IT (ROMA)	participant	174˙999.60
19	EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING Organization address city: Brussels postcode: 1000 contact info Titolo: Ms. Nome: Susanna Cognome: Palkonen Email: send email Telefono: +32 2 227 2712 Fax: +32 2 227 2712	BE (Brussels)	participant	77˙840.25
20	UNIVERSYTET MEDYCZNY W LODZI. Organization address address: Al. Kosciuszki, 4 city: LODZ postcode: 90419 contact info Titolo: Ms. Nome: Aneta Cognome: Andrzejczyk Email: send email Telefono: +48 42 639 31 78 Fax: +48 42 632 14 85	PL (LODZ)	participant	59˙399.60
21	ODENSE UNIVERSITETSHOSPITAL Organization address address: Sdr. Boulevard 29 city: ODENSE postcode: 5000 contact info Titolo: Ms. Nome: Annemette Cognome: Hedegaard Email: send email Telefono: +45 6541 1920 Fax: +45 6541 1920	DK (ODENSE)	participant	55˙000.00
22	BIOMAY AG Organization address address: LAZARETTGASSE 19 city: WIEN postcode: 1090 contact info Titolo: Dr. Nome: Angela Cognome: Neubaeur Email: send email Telefono: 4317970000000 Fax: +43 17966296111	AT (WIEN)	participant	49˙500.00
23	Arizona Board of Regents Organization address address: S. Rural Road 1711 city: Tempe postcode: 85287-3503 contact info Titolo: Ms. Nome: Elizabeth Cognome: Beckett-Firmage Email: send email Telefono: +1 520 626 7441 Fax: +1 520 626 6623	US (Tempe)	participant	0.00

Mappa

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medall health immunology biomarker populations models allergy animal validated fingerprints prevention population integrative genetic mechanisms therapy diseases phenotypes biology network allergic diagnosis environmental ige childhood

Obiettivo del progetto (Objective)

'Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational approach is needed. MeDALL includes experts in allergy, epidemiology, genetics, immunology, biology, animal models, biochemistry and systems biology combining strengths of ongoing EU projects. Classical phenotypes (expert-based) and novel phenotypes of allergy (hypothesis-free statistical modelling) are compared. Population-based data are collected from a cross-sectional study (Karelia) and existing birth-cohorts followed using a common protocol. IgE to foods and inhalants are tested using component-resolved diagnosis across Europe in populations. Biomarker profiles (“fingerprints”) are extensively assessed using epigenetics, targeted proteomics and unbiased transcriptomics in a subsample of the study population. Those associated with allergic phenotypes are validated in large study populations. Relevant fingerprints are combined into network biomarker phenotype “handprints” using a systems biology approach and validated in a sufficiently powered sample. Animal studies and in vitro human immunology reinforce the validation. This information coupled with classical and novel phenotypes characterize environmental protective and susceptibility factors of allergy and risk groups. Results are fitted into new integrative complex mathematical models to establish suitable biomarkers for early diagnosis, prevention and targets for therapy of allergy-associated diseases such as asthma and atopic dermatitis. Ethics and gender are considered. MeDALL aims at improving health of European citizens, Europe competitiveness and innovative capacity while addressing global health issues.'

Introduzione (Teaser)

Understanding how allergies develop is key for prevention and therapy. A large European study is working to unravel the complex network of genetic and environmental factors implicated in allergy development during childhood.