DIATOOLS

Tools for minimally invasive diagnostics

Coordinatore	UPPSALA UNIVERSITET    more  Organization address address: SANKT OLOFSGATAN 10 B city: UPPSALA postcode: 751 05 contact info Titolo: Dr. Nome: Erik Cognome: Ullerås Email: send email Telefono: 46184714432 Fax: 46184714808
Nazionalità Coordinatore	Sweden [SE]
Sito del progetto	http://www.diatools.org/
Totale costo	6˙550˙538 €
EC contributo	5˙000˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2010-two-stage
Funding Scheme	CP-FP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-11-01   -   2014-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UPPSALA UNIVERSITET  Organization address address: SANKT OLOFSGATAN 10 B city: UPPSALA postcode: 751 05 contact info Titolo: Dr. Nome: Erik Cognome: Ullerås Email: send email Telefono: 46184714432 Fax: 46184714808	SE (UPPSALA)	coordinator	1˙429˙737.00
2	INSTITUT CURIE  Organization address address: 26, rue d'Ulm city: PARIS postcode: 75248 contact info Titolo: Ms. Nome: Corinne Cognome: Cumin Email: send email Telefono: +33 1 56 24 66 20 Fax: +33 1 56 24 66 27	FR (PARIS)	participant	966˙132.00
3	OLINK AB  Organization address address: UPPSALA SCIENCE PARK city: UPPSALA postcode: 751 83 contact info Titolo: Dr. Nome: Mats Cognome: Gullberg Email: send email Telefono: 46709428520 Fax: 4618509300	SE (UPPSALA)	participant	589˙600.00
4	FLUIGENT SA  Organization address address: RUE DU FAUBOURG SAINT JACQUES 29 city: PARIS postcode: 75014 contact info Titolo: Dr. Nome: Jérémie Cognome: Weber Email: send email Telefono: +331 46 33 16 06 Fax: +331 46 33 16 68	FR (PARIS)	participant	517˙072.00
5	Q-LINEA AB  Organization address address: DAG HAMMARSKJOLDS VAG 58A city: Uppsala postcode: 75237 contact info Titolo: Dr. Nome: Jonas Cognome: Jarvius Email: send email Telefono: +46 18 444 3612 Fax: +46 18 444 3611	SE (Uppsala)	participant	516˙400.00
6	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY  Organization address address: SERRA MALL 450 city: STANFORD postcode: 94305 2004 contact info Titolo: Dr. Nome: Garry Cognome: Nolan Email: send email Telefono: +1 650 725 7002 Fax: +1 650 723 2383	US (STANFORD)	participant	470˙875.00
7	"USTAV MAKROMOLEKULARNI CHEMIE AV CR, v.v.i."  Organization address address: HEYROVSKEHO NAM. 2 city: PRAHA 6 postcode: 16206 contact info Titolo: Dr. Nome: Daniel Cognome: Horak Email: send email Telefono: +420 296809260 Fax: +420 296809410	CZ (PRAHA 6)	participant	350˙400.00
8	STOCKHOLMS UNIVERSITET  Organization address address: Universitetsvaegen 10 city: STOCKHOLM postcode: 10691 contact info Titolo: Dr. Nome: Erik Cognome: Ullerås Email: send email Telefono: +46 18 4714493	SE (STOCKHOLM)	participant	159˙784.00

Mappa

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 Obiettivo del progetto (Objective)

'A new generation of molecular tools is becoming available that can digitally record numbers, identities and locations of a broad range of molecular markers for increased diagnostic accuracy. This project will for the first time combine synergistically several groundbreaking technological innovations by the partners, notably padlock and proximity probes with rolling circle amplification for single molecule detection and counting, directed self-assembly of solid phases, and advanced microfluidics and read-out techniques, bringing these from the research lab into integrated instruments useful in routine. This will enable minimally invasive diagnostics, prognostics, and follow-up of treatment of cancers. Blood samples and fine needle aspirates will be subjected to high content, multiplex and multimodal assays of nucleic acids, proteins and interacting complexes thereof in single cells as well as in cell-free bodily fluids. We will use flow cytometry to collect multi-parameter information for large populations of cells, and individual detected molecules will be recorded using a fluorescence activated molecule counter developed by one of the partners. Also, very rare cells and molecules will be targeted through enrichment techniques using novel capturing approaches of unprecedented efficiency. We will apply these diagnostic approaches to characterize biomarkers in solid tumors and in leukemia and lymphoma for minimally invasive diagnostics, monitoring disease progress and selecting optimal therapy, and the assays will be clinically validated in small-scale studies of well-characterized patient samples. This project directly addresses four of the five topics in this call.'

Introduzione (Teaser)

Comprehensive molecular analysis tools in medical practice could improve diagnosis and facilitate therapy monitoring. To this end, a European consortium is advancing technologies for the sensitive detection of macromolecular interactions in cells.