SPECIATIONGENOMICS
Genomics of sexual isolation and reinforcement in the house mouse
| Coordinatore | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 45˙000 € |
| EC contributo | 45˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2009-RG |
| Funding Scheme | MC-ERG |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-01-01 - 2014-04-22 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | coordinator | 45˙000.00 |
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Obiettivo del progetto (Objective)
'One main topic in evolutionary biology is this unresolved and fascinating riddle: how do new species arise? In the last two decades, attention focused on the possibility that selection could play a major role in speciation, particularly when reproductive isolation is impeded by ongoing gene flow. Nowadays, the plausibility of adaptive speciation is accepted but the debate is shifting towards the challenges of identifying the factors favouring this process and of assessing the genetic basis of adaptive divergence. This project proposes to address the mechanisms of adaptive speciation in the house mouse, a model species for the study of speciation, by developing a genomics and candidate gene approach which will complement the behavioural and proteomics studies in progress on this biological system. Specifically, the project aims to elucidate the genetic basis of sexual isolation and reinforcement between two European subspecies of the house mouse (Mus musculus domesticus and M. m. musculus) which hybridise in nature but show some degree of prezygotic isolation in their contact zone. Sexual isolation between these two taxa originates from the divergence of the olfactory mate recognition system. Therefore, I propose that loci implicated in pheromone recognition are prime candidates for speciation in the house mouse and I will test this hypothesis by seeking for a signature of divergence under selection in genomic regions containing these candidate genes (Murine Urinary Protein and Vomeronasal Receptor gene families). My approach will be to exploit publicly available genomic resources for the house mouse and recent progress made in the characterisation of chemosensory related gene and the idea will be to combine high throughput technologies and population genetics tools in order to assess divergence both at the sequence and the expression level. Importantly, this project will include for the first time a test of a mechanism of reinforcement at the molecular level.'
Introduzione (Teaser)
The house mouse is an ideal subject for the study of how new species arise. EU research has studied two subspecies that often live side by side but despite this are part of evolution in the making.