VISFATIN
RELEVANCE OF DIETARY FATTY ACIDS AND VITAMIN B3 FOR MANAGING VISFATIN-MEDIATED DYSLIPIDEMIA AND INFLAMMATION IN OBESITY
| Coordinatore | AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
| Nazionalità Coordinatore | Spain [ES] |
| Totale costo | 45˙000 € |
| EC contributo | 45˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2010-RG |
| Funding Scheme | MC-ERG |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-10-01 - 2013-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | coordinator | 45˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'Hyperlipemia and particularly, postprandial lipemia is involved in atherogenesis and is characterized by a rise of triglyceride-rich lipoproteins (TRL) after a rich fat meal. Recent studies have suggested hypolipidaemic and anti-inflammatory effects, and insulin sensitivity improvement by dietary monounsaturated fatty acids (MUFA) during the postprandial state.Vitamin B3 (nicotinic acid) has been used for treatment of dyslipidaemia associated with metabolic syndrome. Olive oil, as the main natural source of MUFA, and vitamin B3 have emerged as nutrition intervention strategies for prevention of cardiovascular disease risk at short- and long-term, respectively. Visfatin is an adipocytokine with nicotinamide phosphoribosyltransferase activity that catalyzes first step in the biosynthesis of NAD from nicotinamide. Extracellular visfatin converts nicotinamide into nicotinamide mononucleotide in blood, which functions as a systemic signalling molecule regulating β cell function and inflammatory responses. A regulatory role for dietary fatty acids on visfatin gene expression has been described in an in vitro model of murine adipocytes. However, there is no virtually any data about the mechanisms by which dietary fatty acids and vitamin B3, alone or in combination could regulate visfatin homeostasis in vivo, particularly in the postprandial state. We hypothesized that different dietary fats in combination with vitamin B3 may have a key role on visfatin activity which may lead to modulation of inflammation and vascular dysfunction that are overproduced in vascular diseases. We envision achieving this through the following set of key objectives: -To determine the influence of MUFA versus SFA or omega-3 PUFA supplemented by vitamin B3 on visfatin modulation in a human postprandial (short-term) model. -To point out the influence of long-term dietary MUFA versus SFA or omega-3 PUFA supplemented by vitamin B3 on visfatin homeostasis in an metabolic syndrome mouse model.'
Introduzione (Teaser)
Vitamin B3 is known to have lipid-modulating effects in terms of reducing bad cholesterol levels and atherosclerosis. Olive oil and fish oil consumption are also beneficial for our health.