THROMBUS

A quantitative model of thrombosis in intracranial aneurysms

Coordinatore	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE    more  Organization address address: av Albert Einstein 2 city: Villeurbanne postcode: 69609 contact info Titolo: Dr. Nome: Pascaline Cognome: TOUTOIS Email: send email Telefono: +33 4 72 44 56 90 Fax: +33 4 78 89 08 51
Nazionalità Coordinatore	France [FR]
Totale costo	3˙720˙723 €
EC contributo	2˙813˙000 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2009-6
Funding Scheme	CP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-02-01   -   2014-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: av Albert Einstein 2 city: Villeurbanne postcode: 69609 contact info Titolo: Dr. Nome: Pascaline Cognome: TOUTOIS Email: send email Telefono: +33 4 72 44 56 90 Fax: +33 4 78 89 08 51	FR (Villeurbanne)	coordinator	0.00
2	COVALIA INTERACTIVE  Organization address address: RUE PROFESSEUR PAUL MILLERET city: BESANCON postcode: 25000 contact info Titolo: Dr. Nome: Eric Cognome: GARCIA Email: send email Telefono: +33 3 81 83 21 73 Fax: +33 3 81 25 53 51	FR (BESANCON)	participant	0.00
3	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Jean-Philippe Cognome: Thiran Email: send email Telefono: +41 21 693 4623 Fax: +41 21 693 7600	CH (LAUSANNE)	participant	0.00
4	EV3 EUROPE SAS  Organization address address: RUE LA BOETIE city: PARIS postcode: 75008 contact info Titolo: Mr. Nome: Jérôme Cognome: Erath Email: send email Telefono: 33156885919 Fax: 33156883111	FR (PARIS)	participant	0.00
5	HOSPICES CIVILS DE LYON  Organization address address: 3 Quai des Celestins city: LYON postcode: 69229 contact info Titolo: Ms. Nome: Cecile Cognome: LEGROS Email: send email Telefono: +33 4 72 40 68 60 Fax: +33 4 72 40 68 69	FR (LYON)	participant	0.00
6	INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON  Organization address address: AVENUE ALBERT EINSTEIN city: VILLEURBANNE postcode: 69100 contact info Titolo: Ms. Nome: Françoise Cognome: MARTIN Email: send email Telefono: +33 4 72 43 79 83	FR (VILLEURBANNE)	participant	0.00
7	UNIVERSITAET SIEGEN  Organization address address: HERRENGARTEN city: SIEGEN postcode: 57072 contact info Nome: Katja Cognome: Bieler Email: send email Telefono: 492717000000 Fax: 4927170000000	DE (SIEGEN)	participant	0.00
8	UNIVERSITE DE GENEVE  Organization address address: RUE DU GENERAL DUFOUR city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Bastien Cognome: Chopard Email: send email Telefono: 41223790219 Fax: 41223790250	CH (GENEVE)	participant	0.00
9	UNIVERSITE LIBRE DE BRUXELLES  Organization address address: Avenue Franklin Roosevelt city: BRUXELLES postcode: 1050 contact info Titolo: Prof. Nome: Christine Cognome: COURILLON Email: send email Telefono: +32 2 650 67 18 Fax: +32 2 650 23 21	BE (BRUXELLES)	participant	0.00
10	UNIVERSITEIT VAN AMSTERDAM  Organization address address: SPUI city: AMSTERDAM postcode: 1012WX contact info Titolo: Ms. Nome: Vanessa Cognome: Wolters Email: send email Telefono: 31205257876 Fax: 31205257419	NL (AMSTERDAM)	participant	0.00

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 Obiettivo del progetto (Objective)

Rupture risk of intracranial aneurysms (IA) has been studied at length. However, very little is known about the healing mechanism, namely the formation of a clot inside the cavity after insertion of a stent. The multiscale interaction between biological and hemodynamic processes is the central ingredient of this proposal. The core of the project is to develop and validate a biological model of spontaneous or stent-induced thrombosis in IA. From this model we will compute quantitative stent efficiency score by its capability to induce clotting in aneurysms. In medical practice the choice of which stent to deploy is left to the medical doctor and remains intuitive to date. It is common to use one or several full-course stents into each other, in order to induce thrombosis formation. Recent Pipieline stents allowing simple or multiple devices constructs with variable flow disruption will be investigated. Our project will study through numerical simulation the effect of stent configuration in patient specific geometry and will help explain why some stents produce good thrombus while others don't. The project will develop a multiscale computational modelling and simulation framework based on the triptych In Vitro - In Vivo - In Silico - rule of three for the thrombosis. The associated technological aim of the project is to deliver software with an interactive end-user interface, providing a virtual simulation of the thrombosis leading to the optimal stent for a specific patient's aneurysm. This goal will be achieved by integrating some of the leading open source software and VPH toolkit software in the area of computational bioengineering. Also a collaborative online system will be adapted allowing partners of THROMBUS to correlate any type of data in case simultaneous multidisciplinary analysis by distant partners is required. This platform will remain operational after the end of the project.