COSMOS
Integrated In Silico Models for the Prediction of Human Repeated Dose Toxicity of Cosmetics to Optimise Safety
| Coordinatore | LIVERPOOL JOHN MOORES UNIVERSITY
Organization address
address: Egerton Court Rodney Street 2 contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 6˙797˙335 € |
| EC contributo | 3˙344˙666 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2010-Alternative-Testing |
| Funding Scheme | CP-IP |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-01-01 - 2015-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
LIVERPOOL JOHN MOORES UNIVERSITY
Organization address
address: Egerton Court Rodney Street 2 contact info |
UK (LIVERPOOL) | coordinator | 577˙496.00 |
| 2 |
Molecular Networks GmbH - Computerchemie
Organization address
address: Henkestrasse 91 contact info |
DE (Erlangen) | participant | 435˙200.00 |
| 3 |
INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
Organization address
address: Parc Technologique Alata contact info |
FR (VERNEUIL EN HALATTE) | participant | 365˙000.00 |
| 4 |
JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Organization address
address: Rue de la Loi 200 contact info |
BE (BRUSSELS) | participant | 355˙026.00 |
| 5 |
UNIVERSITY OF BRADFORD
Organization address
address: RICHMOND ROAD contact info |
UK (BRADFORD) | participant | 282˙500.00 |
| 6 |
KNIME.COM AG
Organization address
address: TECHNOPARKSTRASSE 1 contact info |
CH (ZURICH) | participant | 250˙000.00 |
| 7 |
INSTITUT PO BIOFIZIKA I BIOMEDITSINSKO INZHENERSTVO (INSTITUTE OF BIOPHYSICS AND BIOMEDICAL ENGINEERING)
Organization address
address: Akad. G. Bonchev bl. 21 contact info |
BG (Sofia) | participant | 240˙000.00 |
| 8 |
ALTAMIRA LLC
Organization address
address: CANDLEWOOD DRIVE 1455 contact info |
US (COLUMBUS OH) | participant | 237˙500.00 |
| 9 |
S-IN SOLUZIONI INFORMATICHE SRL
Organization address
address: VIA G FERRARI 14 contact info |
IT (VICENZA) | participant | 229˙444.00 |
| 10 |
INSILICO BIOTECHNOLOGY AG
Organization address
address: MEITNERSTRASSE 8 contact info |
DE (STUTTGART) | participant | 195˙000.00 |
| 11 |
INTERNATIONAL LIFE SCIENCES INSTITUTE EUROPEAN BRANCH AISBL
Organization address
address: Av. E. Mounier 83 contact info |
BE (BRUXELLES) | participant | 117˙500.00 |
| 12 |
KEMIJSKI INSTITUT
Organization address
address: HAJDRIHOVA 19 contact info |
SI (LJUBLJANA) | participant | 45˙000.00 |
| 13 |
MERCK KGAA
Organization address
address: Frankfurter Strasse 250 contact info |
DE (DARMSTADT) | participant | 15˙000.00 |
| 14 |
HENKEL KGaA
Organization address
address: HENKELSTRASSE 67 contact info |
DE (DUSSELDORF) | participant | 0.00 |
| 15 |
U.S. Food & Drug Administration
Organization address
address: New Hampshire Avenue 10903 contact info |
US (Silver Spring) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'The COSMOS project will address the assessment needs of the cosmetics industry by delivering an integrated suite of computational tools to predict the effects of long-term exposure to cosmetic ingredients in humans, thus reducing the need for repeated dose toxicity testing in animals. To achieve this, individual modules comprising: (new) databases, thresholds of toxicological concern (TTC), in silico toxicology (grouping, read-across and QSAR), in vitro data and physiologically-based pharmacokinetic (PBPK) modelling, will be used to construct flexible workflows for assessing toxicity. The COSMOS project will be informed by the needs of industry through active stakeholder engagement, and will utilise innovative technologies from outside the cosmetics area. New databases for TTC and modelling studies will be created by harvesting US FDA legacy data for cosmetics. New and current databases will be combined to advance the state-of-the-art providing a transparent, freely-available public resource. Grouping and read-across will be achieved mechanistically and on the basis of structural similarity. The effective dose-response at the target organ will be estimated from in vitro effects and PBPK models, establishing an alternative (non-animal) basis for risk assessment. All models and Workflows developed will be transparent, fully documented and open access. The partners include world leaders committed to donating software and algorithms to support the open architecture. Data and models will be integratable with existing systems. Workflows will be automated through the KNIME software.'
Introduzione (Teaser)
Researchers have developed a complete system to evaluate cosmetic toxicity without animal testing. It makes use of an integrated suite of simulations and other computational tools.