NPMIMETIC
Biomimetic nano-fiber-based nucleus pulposus regeneration for the treatment of degenerative disc disease
| Coordinatore | STICHTING VU-VUMC
Organization address
address: DE BOELELAAN 1105 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 5˙178˙698 € |
| EC contributo | 3˙985˙587 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2009-SMALL-3 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-02-01 - 2015-01-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
STICHTING VU-VUMC
Organization address
address: DE BOELELAAN 1105 contact info |
NL (AMSTERDAM) | coordinator | 415˙766.56 |
| 2 |
NICAST LTD
Organization address
address: YODFAT 2 NORTHERN INDUSTRAIAL ZONE contact info |
IL (LOD) | participant | 549˙481.00 |
| 3 |
AO-FORSCHUNGSINSTITUT DAVOS
Organization address
address: Clavadelerstrasse 8 contact info |
CH (Davos Platz) | participant | 532˙382.00 |
| 4 |
PROCORE LTD
Organization address
address: GOLDA MEIR 7 WEIZMANN SCIENCE PARK 7 contact info |
IL (NES ZIONA) | participant | 491˙200.00 |
| 5 |
UNIVERSITAET ZUERICH
Organization address
address: Raemistrasse 71 contact info |
CH (ZURICH) | participant | 453˙560.00 |
| 6 |
SHEFFIELD HALLAM UNIVERSITY
Organization address
address: HOWARD STREET contact info |
UK (SHEFFIELD) | participant | 449˙088.00 |
| 7 |
UNIVERSIDADE DO MINHO
Organization address
address: Largo do Paco contact info |
PT (BRAGA) | participant | 407˙900.00 |
| 8 |
OSM-DAN LTD.
Organization address
address: Pekeris Street 4 contact info |
IL (REHOVOT) | participant | 215˙640.00 |
| 9 |
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Organization address
address: De Boelelaan 1105 contact info |
NL (AMSTERDAM) | participant | 211˙989.44 |
| 10 |
CM Developpement
Organization address
address: Rue Le Corbusier 47 contact info |
FR (Boulogne Billancourt) | participant | 187˙740.00 |
| 11 |
MELAB MEDIZINTECHNIK UND LABOR GMBH
Organization address
address: GARTENSTRASSE 12 contact info |
DE (FRIOLZHEIM) | participant | 70˙840.00 |
Mappa
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Obiettivo del progetto (Objective)
'The intervertebral discs form the elastic part of the spine. It is composed of the annulus fibrosus, a tough outer layer of fibrocartilage, surrounding an elastic gelatinous core, the nucleus pulposus (NP). With age, the water content of the NP decreases, thus, the mechanical loads concentrate on the annulus. This leads to the NP wear, and cracking with a subsequent inflammation reaction and a prolapsed intervertebral disc. The process forms a cycle of accelerated DDD pathology. The 'Gold Standard' for treatment is the 'spinal fusion', an extensive surgery, which blocks definitively free spine motion. Surgeons seek new technologies to allow motion preservation, with long-term outcomes. Based on electrospinning proprietary technology of partner NIC and a novel chemically modified ECM-based biopolymer, developed by partner ProCore, the NPmimetic consortium will develop biomimetic nano-polymer based gel for minimally invasive treatment for disc regeneration: Electrospinning technology will be exploited to design and develop nano-fiber based, biocompatible, biodegradable, synthetic scaffold that will mimic mechanical properties of native NP for immediate and short term treatment. Anti-inflammatory drugs will be carried by biodegradable nano-fibers to be gradually released in situ thus, healing and preventing inflammation. Furthermore, the synthetic scaffold will be integrated with the bioactive-polymer that is highly potent in supporting NP cells for long-term cure. A multidisciplinary study will answer scientific and engineering questions raised by the NPmimetic approach, e.g. hydrogel swelling characteristics, drug delivery, and NP cells reaction to the biomimetic gel environment. All will be supervised by a strong leader in spine surgery to define inputs and outputs of the research, from a clinical implementation point of view.'
Introduzione (Teaser)
Millions of people suffer from back pain, often due to herniated or degenerated discs. Scientists are developing technology to regenerate and rebuild the disc within the body through minimally invasive solutions.