NPMIMETIC

Biomimetic nano-fiber-based nucleus pulposus regeneration for the treatment of degenerative disc disease

Coordinatore	STICHTING VU-VUMC    more  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Dr. Nome: Marco N Cognome: Helder Email: send email Telefono: +31 20 44 45024 Fax: +31 20 44 42357
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	5˙178˙698 €
EC contributo	3˙985˙587 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2009-SMALL-3
Funding Scheme	CP-FP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-02-01   -   2015-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STICHTING VU-VUMC  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Dr. Nome: Marco N Cognome: Helder Email: send email Telefono: +31 20 44 45024 Fax: +31 20 44 42357	NL (AMSTERDAM)	coordinator	415˙766.56
2	NICAST LTD  Organization address address: YODFAT 2 NORTHERN INDUSTRAIAL ZONE city: LOD postcode: 71291 contact info Titolo: Mr. Nome: Benjamin Cognome: Eliason Email: send email Telefono: +972 8 9153001 Fax: +972 8 9153002	IL (LOD)	participant	549˙481.00
3	AO-FORSCHUNGSINSTITUT DAVOS  Organization address address: Clavadelerstrasse 8 city: Davos Platz postcode: 7270 contact info Titolo: Dr. Nome: Mauro Cognome: Alini Email: send email Telefono: 41814142310	CH (Davos Platz)	participant	532˙382.00
4	PROCORE LTD  Organization address address: GOLDA MEIR 7 WEIZMANN SCIENCE PARK 7 city: NES ZIONA postcode: 70400 contact info Titolo: Prof. Nome: Avner Cognome: Yayon Email: send email Telefono: 97289303000 Fax: 97289367544	IL (NES ZIONA)	participant	491˙200.00
5	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Prof. Nome: Franz Cognome: Weber Email: send email Telefono: 41442555055 Fax: 41442554179	CH (ZURICH)	participant	453˙560.00
6	SHEFFIELD HALLAM UNIVERSITY  Organization address address: HOWARD STREET city: SHEFFIELD postcode: S1 1WB contact info Titolo: Dr. Nome: Chris Cognome: Sammon Email: send email Telefono: 441142000000 Fax: 441142000000	UK (SHEFFIELD)	participant	449˙088.00
7	UNIVERSIDADE DO MINHO  Organization address address: Largo do Paco city: BRAGA postcode: 4704553 contact info Titolo: Prof. Nome: José Carlos Cognome: Pimenta Claro Email: send email Telefono: +351 253510221 Fax: +351 253516007	PT (BRAGA)	participant	407˙900.00
8	OSM-DAN LTD.  Organization address address: Pekeris Street 4 city: REHOVOT postcode: 76702 contact info Titolo: Dr. Nome: Pnina Cognome: Dan Email: send email Telefono: +972 8 9460012 Fax: +972 9 9361486	IL (REHOVOT)	participant	215˙640.00
9	VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG  Organization address address: De Boelelaan 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Dr. Nome: Marco N Cognome: Helder Email: send email Telefono: +31 20 44 45024 Fax: +31 20 44 42357	NL (AMSTERDAM)	participant	211˙989.44
10	CM Developpement  Organization address address: Rue Le Corbusier 47 city: Boulogne Billancourt postcode: 92100 contact info Titolo: Prof. Nome: Christian Cognome: Mazel Email: send email Telefono: 33607587723 Fax: 33156616337	FR (Boulogne Billancourt)	participant	187˙740.00
11	MELAB MEDIZINTECHNIK UND LABOR GMBH  Organization address address: GARTENSTRASSE 12 city: FRIOLZHEIM postcode: 71292 contact info Titolo: Dr. Nome: Peter Cognome: Kinast Email: send email Telefono: +49 7152 949313 Fax: +49 7152 949314	DE (FRIOLZHEIM)	participant	70˙840.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'The intervertebral discs form the elastic part of the spine. It is composed of the annulus fibrosus, a tough outer layer of fibrocartilage, surrounding an elastic gelatinous core, the nucleus pulposus (NP). With age, the water content of the NP decreases, thus, the mechanical loads concentrate on the annulus. This leads to the NP wear, and cracking with a subsequent inflammation reaction and a prolapsed intervertebral disc. The process forms a cycle of accelerated DDD pathology. The 'Gold Standard' for treatment is the 'spinal fusion', an extensive surgery, which blocks definitively free spine motion. Surgeons seek new technologies to allow motion preservation, with long-term outcomes. Based on electrospinning proprietary technology of partner NIC and a novel chemically modified ECM-based biopolymer, developed by partner ProCore, the NPmimetic consortium will develop biomimetic nano-polymer based gel for minimally invasive treatment for disc regeneration: Electrospinning technology will be exploited to design and develop nano-fiber based, biocompatible, biodegradable, synthetic scaffold that will mimic mechanical properties of native NP for immediate and short term treatment. Anti-inflammatory drugs will be carried by biodegradable nano-fibers to be gradually released in situ thus, healing and preventing inflammation. Furthermore, the synthetic scaffold will be integrated with the bioactive-polymer that is highly potent in supporting NP cells for long-term cure. A multidisciplinary study will answer scientific and engineering questions raised by the NPmimetic approach, e.g. hydrogel swelling characteristics, drug delivery, and NP cells reaction to the biomimetic gel environment. All will be supervised by a strong leader in spine surgery to define inputs and outputs of the research, from a clinical implementation point of view.'

Introduzione (Teaser)

Millions of people suffer from back pain, often due to herniated or degenerated discs. Scientists are developing technology to regenerate and rebuild the disc within the body through minimally invasive solutions.