GENSTAGE

Genome Stability Mechanisms in Aging

Coordinatore	KLINIKUM DER UNIVERSITAET ZU KOELN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙448˙400 €
EC contributo	1˙448˙400 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091118
Funding Scheme	ERC-SG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-07-01   -   2017-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAET ZU KOELN  Organization address address: ALBERTUS MAGNUS PLATZ city: KOELN postcode: 50923 contact info Titolo: Dr. Nome: Christian Cognome: Klar Email: send email Telefono: +49 2214705498 Fax: +49 2214705279	DE (KOELN)	beneficiary	447˙774.00
2	KLINIKUM DER UNIVERSITAET ZU KOELN  Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 contact info Titolo: Ms. Nome: Petra Cognome: Schreiner-Kaub Email: send email Telefono: +49 221 478 98413 Fax: +49 221 478 1498413	DE (KOELN)	hostInstitution	1˙000˙626.00
3	KLINIKUM DER UNIVERSITAET ZU KOELN  Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 contact info Titolo: Prof. Nome: Bjoern Cognome: Schumacher Email: send email Telefono: 4922150000000 Fax: 4922150000000	DE (KOELN)	hostInstitution	1˙000˙626.00

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 Obiettivo del progetto (Objective)

'Genome Instability has been recognized as causal factor of cancer and recently also as a major contributing factor of aging. A number of progeroid (premature aging-like) syndromes are linked to defects in nucleotide excision repair (NER). NER thus provides a highly relevant experimental system to study the role of genome stability in aging. Using the NER system we recently uncovered a novel link between DNA damage accumulation and the regulation of longevity assurance programs. We propose to use the powerful genetic system of C. elegans to identify mechanisms through which the stochastic accumulation of damage impacts aging and genetic pathways of longevity regulation. We will pursue three complementary experimental strategies: (1) genetic identification of novel response pathways to persistent DNA damage, (2) investigation of DNA damage resistance mechanisms that promote longevity, and (3) a targeted candidate approach to uncover the underlying mechanisms that ensure genome integrity in lifespan extension. This proposal aims at the discovery of novel genes functioning in genome stability and longevity regulation that might be instrumental for the development of preventive therapeutic strategies for age-related pathologies as well as for the treatment of rare genetic progeroid disorders.'