CCRYSTAL

Innovative equipment and methodologies for APIs continuous crystallization

Coordinatore	Ashe Morris Ltd    more  Organization address address: "AGP, Sterling House, Centre Park" city: Warrington postcode: WA1 1GG contact info Titolo: Ms. Nome: Gilda Cognome: Gasparini Email: send email Telefono: +44 1928 515454 Fax: +44 1928 515453
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙499˙875 €
EC contributo	1˙105˙500 €
Programma	FP7-SME Specific Programme "Capacities": Research for the benefit of SMEs
Code Call	FP7-SME-2010-1
Funding Scheme	BSG-SME
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-11-01   -   2012-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Ashe Morris Ltd  Organization address address: "AGP, Sterling House, Centre Park" city: Warrington postcode: WA1 1GG contact info Titolo: Ms. Nome: Gilda Cognome: Gasparini Email: send email Telefono: +44 1928 515454 Fax: +44 1928 515453	UK (Warrington)	coordinator	405˙975.00
2	MERCHAV ENGINEERING LTD  Organization address address: FRIESCHMAN ST 33 city: KIRYAT ATA postcode: 28110 contact info Titolo: Mr. Nome: Zvi Cognome: Merchav Email: send email Telefono: +972 4 845 44 28 Fax: +972 4 8454429	IL (KIRYAT ATA)	participant	254˙175.00
3	GALENTIS SRL  Organization address address: Via Tiraboschi 48 city: Bergamo postcode: 24100 contact info Titolo: Dr. Nome: Luca Cognome: Zambelli Email: send email Telefono: +39 041 4567349 Fax: +39 041 5958987	IT (Bergamo)	participant	249˙850.00
4	FLAMMA S.P.A.  Organization address address: VIA BEDESCHI 22 city: CHIGNOLO D ISOLA postcode: 24040 contact info Titolo: Dr. Nome: Rossella Cognome: Pedroncelli Email: send email Telefono: +39 035 499 1811 Fax: +39 035 499 1812	IT (CHIGNOLO D ISOLA)	participant	132˙595.12
5	SERICHIM S.r.l.  Organization address address: Piazzale Marinotti 1 city: Torviscosa postcode: 33050 contact info Titolo: Dr. Nome: Delogu Cognome: Pietro Email: send email Telefono: 390431000000 Fax: 390431000000	IT (Torviscosa)	participant	25˙325.00
6	Autico Ltd  Organization address address: BROADWAY ROAD WEST LEIGH city: ILMINSTER SOMERSET postcode: TA19 9RA contact info Titolo: Mr. Nome: Poole Cognome: Kevin Email: send email Telefono: 44146055768	UK (ILMINSTER SOMERSET)	participant	16˙000.00
7	Process Systems Enterprise Ltd  Organization address address: "6th Floor East, Hammersmith Bridge Road 26-28" city: London postcode: W6 7HA contact info Titolo: Dr. Nome: Sean Cognome: Bermingham Email: send email Telefono: +44 20 8563 0888 Fax: +44 20 8563 0999	UK (London)	participant	8˙445.00
8	licensing development and trading international s.r.l.  Organization address address: Via Camperio 9 city: milano postcode: 20123 contact info Titolo: Mr. Nome: Antonio Cognome: Garavaglia Email: send email Telefono: +39 02 89409392 Fax: +39 02 89421104	IT (milano)	participant	7˙434.88
9	FLAMMA  Organization address address: via Bedeschi 22 city: Chignolo d'isola postcode: 24040 contact info Titolo: Mr. Nome: Gian Paolo Cognome: Negrisoli Email: send email Telefono: +39 035 4991811 Fax: +39 035 4991812	IT (Chignolo d'isola)	participant	5˙700.00

Mappa

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 Obiettivo del progetto (Objective)

'In spite of the substantial erosion of its market share, western Europe (Italy, Spain are respectively first and second producers) still remains the worldwide leader, accounting for 38,9% of the world APIs production and Eastern Europe is growing faster (mainly represented by Hungary). It is then clear that generic APIs represent a strategic industrial field for EU competitiveness, and it is as well clear that this competitiveness is seriously threatened by the emerging competitors in the Far Eastern Countries (China and India above all). The reasons behind this loss of competitiveness is manifold: (i) lower man power costs in the Emerging countries, (ii) lack of regulatory requirements in the emerging Countries, are the most obvious. The CCRYSTAL main objective is to develop a new technology to crystallize pharmaceutical substances, affording fundamental new approaches to obtain products with high purity levels and constant and reproducible crystalline forms at a competitive price, enabling EU APIs industry to regain his competitiveness against Asian Producers. The innovative proposed technologies are based on a new concept crystallizer and on continuous mode operation. Crystallizer is designed in such a way to assure a perfect actuation of elaborated operation strategies, intended to control the main phenomena involved in crystal formation: (i) Primary nucleation; (ii) Secondary nucleation; (iii) Crystal growth. The new technology will be tested on competitive APIs, eventually developing the whole chemical scheme in a continuous manner. Further a single crystallizer (a “repeatable unit”) is then arranged in a crystallization train of three units, to allow flow operation.'