MELOVISION

Melanopsin-based vision in health and disease

Coordinatore	THE UNIVERSITY OF MANCHESTER    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙499˙636 €
EC contributo	2˙499˙636 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100317
Funding Scheme	ERC-AG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-05-01   -   2016-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Ms. Nome: Liz Cognome: Fay Email: send email Telefono: +44 161 2757114 Fax: 441613000000	UK (MANCHESTER)	hostInstitution	2˙499˙636.00
2	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Prof. Nome: Robert James Cognome: Lucas Email: send email Telefono: +44 161 2755251 Fax: +44 161 2755948	UK (MANCHESTER)	hostInstitution	2˙499˙636.00

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 Obiettivo del progetto (Objective)

'It is now >10 years since the remarkable discovery that photoreception in the mammalian retina occurs outside of rod and cone cells. In that time we have learnt a great deal about the melanopsin expressing retinal ganglion cells (mRGCs) that provide this non-rod non-cone photoreception, and about their extensive contribution to sub-conscious light responses. However, one idea that has persisted is that these mRGCs play little if any role in visual perception. Exciting new data challenge that view. Thus, we have recently described an extraordinarily extensive mRGC input to the primary visual pathway. This provides ~40% of neurones in the mouse visual thalamus with melanopsin signals, superimposed upon more conventional visual information. The discovery of this unexpected sensory input to the mammalian visual system raises several important questions: What does it contribute to vision? How is the melanopsin signal brought to the thalamus and how is it propagated/processed through higher visual centres? Does melanopsin help people with retinal degeneration (in which mRGCs long outlive rods and cones) to see? Could optimising melanopsin vision offer a new strategy for improving vision in these people? We propose addressing these questions by using state-of-the-art neurophysiological and anatomical techniques in mice. Our overarching objectives are Objective 1: What does melanopsin contribute to vision? Objective 2: How is melanopsin vision impacted by retinal degeneration?'