NEUROGLIAFORM CELLS

Contribution of neurogliaform cells to signal flow in the barrel cortex during whisking behaviour

Coordinatore	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE    more  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Carl Cognome: Petersen Email: send email Telefono: +41 21 693 1721 Fax: +41 21 693 8353
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	178˙601 €
EC contributo	178˙601 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-01   -   2014-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Carl Cognome: Petersen Email: send email Telefono: +41 21 693 1721 Fax: +41 21 693 8353	CH (LAUSANNE)	coordinator	178˙601.60

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 Obiettivo del progetto (Objective)

'The barrel cortex is the part of rodent primary somatosensory cortex which is responsible for the tactile representation of whiskers. It is recognized as a key model system for understanding fundamental aspects of active sensory processing and more generally investigations into this cortical area have already provided a large amount of information about the basic architecture of cortical microcircuits. A considerable amount of information has been gathered about barrel cortex microcircuits from in vitro brain slice experiments, which forms a basis for understanding the differential roles of the various classes of excitatory and inhibitory neurons. However, we know much less about how these cells function in awake behaving animals. Recent improvements of the whole-cell patch-clamp recording technique make it possible to record from neurons in the cerebral cortex of anaesthetized and awake animals Neurogliaform cells appear to play a unique role in cortical microcircuits. A single firing of a neurogliaform cell can activate both postsynaptic and presynaptic GABA-B and extrasynaptic GABA-A receptors residing outside the synaptic clefts. This gives to these cells the capacitiy of evoking long lasting inhibition of dendritic origin in the overwhelming majority of neighbouring neurons, besides the capacity of suppressing overall synaptic transmission in vicinity of them. My first research objective is to carry out dual in vivo whole-cell patch-clamp recordings from identified neurogliaform cells and from other neighbouring cells in layer 2/3 of barrel cortex of awake behaving animals and subsequently in order to investigate the consequences of synchronized activity of neighbouring neurogliaform cells on the operation of barrel cortex microcircuits, My second research objective is to manipulate them by optogenetical techinques through viral expression of channelrhodopsin 2 and halorhodopsin.'

Introduzione (Teaser)

Neurogliaform cells (NGFCs) are interneurons present within the central nervous system and act as connectors between other neurons. EU-funded research investigated their role in the neocortex of mice.