NANOPHYS

"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons"

Coordinatore	Institute of Science and Technology Austria    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Austria [AT]
Totale costo	2˙500˙000 €
EC contributo	2˙500˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100317
Funding Scheme	ERC-AG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-06-01   -   2016-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Institute of Science and Technology Austria  Organization address address: Am Campus 1 city: Klosterneuburg postcode: 3400 contact info Titolo: Ms. Nome: Carla Cognome: Mazuheli-Chibidziura Email: send email Telefono: +43 2243 9000 1038 Fax: +43 2243 9000 2000	AT (Klosterneuburg)	hostInstitution	2˙500˙000.00
2	Institute of Science and Technology Austria  Organization address address: Am Campus 1 city: Klosterneuburg postcode: 3400 contact info Titolo: Prof. Nome: Peter Cognome: Jonas Email: send email Telefono: +43 2243 9000 3701 Fax: +43 2243 9000 2000	AT (Klosterneuburg)	hostInstitution	2˙500˙000.00

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 Obiettivo del progetto (Objective)

'In the present proposal, we plan to examine the dendrites, axons, and presynaptic terminals of fast-spiking, parvalbumin-expressing GABAergic interneurons using subcellular patch-clamp methods pioneered by the PI, imaging techniques, and computational approaches. The goal is to obtain a quantitative nanophysiological picture of signaling in this key type of interneuron. By incorporating realistic BC models into dentate gyrus network models, we will be able to test the contribution of this important type of GABAergic interneuron to complex functions of the dentate gyrus, such as pattern separation, temporal deconvolution, and conversion from grid to place codes. The results may lay the basis for the development of new therapeutic strategies for treatment of diseases of the nervous system, targeting interneurons at subcellularly defined locations.'