ITCSCEN

Binuclear Non-Coupled Copper Enzymes in Neurobiology: An Integrated Computational/Spectroscopic Investigation

Coordinatore	UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE.    more  Organization address address: "Ellison Place, Ellison Building" city: NEWCASTLE UPON TYNE postcode: NE1 8ST contact info Titolo: Prof. Nome: Gary Cognome: Black Email: send email Telefono: +44 191 2273550 Fax: +44 191 2273519
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	258˙386 €
EC contributo	258˙386 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IOF
Funding Scheme	MC-IOF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-05-16   -   2014-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE.  Organization address address: "Ellison Place, Ellison Building" city: NEWCASTLE UPON TYNE postcode: NE1 8ST contact info Titolo: Prof. Nome: Gary Cognome: Black Email: send email Telefono: +44 191 2273550 Fax: +44 191 2273519	UK (NEWCASTLE UPON TYNE)	coordinator	258˙386.80

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 Obiettivo del progetto (Objective)

'Every third protein contains metal as cofactor. Cu-enzymes plays crucial rules in key processes in bioenergetics, mitochondrial respiration, neurotransmitter biosynthesis, antioxidation and pigmentation Therefore they are intensive targets for discovering new drugs and the understanding of their structure-functions relationships will provide new insight in translational and biomedical research. In this Marie Curie International Outgoing Fellowship I will investigate the mechanism of important two bi nuclear cupper enzyme – Peptidylglycine α-Amidating Monooxygenase (PAM) and Dopamine β-Monooxygense (DBM) which catalyze hydroxylation of substrates in crucial importance for neurobiology . The miss functionalities of these enzymes are related with nervous system disorders therefore revealing it mechanism will provide advanced opportunities for design of new drugs. In order to achieve this knowledge we will apply integrated combination of the most advanced spectroscopic techniques and state of the art computational methods.'

Introduzione (Teaser)

Scientists have shed light on the mechanisms of function of two important copper (Cu)-containing enzymes involved in nervous system disorders. Increased understanding should lead to advances in drug design, protein engineering and biotechnology.