TRANSLATOMICS

Painting the landscape of translational control of gene expression through meta-analysis of genome wide data sets

Coordinatore	KAROLINSKA INSTITUTET    more  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Maria Cognome: Von Witting Email: send email Telefono: +46 8 517 758 78 Fax: +46 517 706 90
Nazionalità Coordinatore	Sweden [SE]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-IRG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2015-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Maria Cognome: Von Witting Email: send email Telefono: +46 8 517 758 78 Fax: +46 517 706 90	SE (STOCKHOLM)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Translational control determines the rate at which mRNAs are synthesized into proteins; regulates biological processes ranging from apoptosis to memory; and shows deregulation in diseases such as fibrosis and cancer. In cancer, dysregulated translational control is associated with worse prognosis in most sold cancer. Despite this, integrated genome wide knowledge of translational control and its regulatory mechanisms is lacking. My new methods for data analysis and mechanistic discoveries allow, for the first time, efficient genome wide studies of translational control. By using all publicly available genome-wide data sets and these methods we will characterize the landscape of translational control by identifying genes and pathways that are regulated translationally; groups of genes that constitute functional translational modules and show co-regulation across many biological conditions; key genes that are highly connected (nodes) and under translational control; network structures that are regulated at the translational level; and mechanisms that mediate such regulation. This information will be used to compare many biological processes to generate an integrated perspective of translational control. Through functional experiments employing both gene specific and regulatory mechanism focused approaches we will link translational control, genes, mechanisms for regulation and biological processes to unravel a new level of understanding of translational control. Such knowledge will be applicable in future studies of how dysregulation of translational control contributes to human disease.'

Introduzione (Teaser)

When regulation of gene expression breaks down, the result can be cancer. A new statistical approach is tackling translational control on a genome-wide level.