Coordinatore | KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
Nazionalità Coordinatore | Sweden [SE] |
Totale costo | 100˙000 € |
EC contributo | 100˙000 € |
Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
Code Call | FP7-PEOPLE-2010-RG |
Funding Scheme | MC-IRG |
Anno di inizio | 2011 |
Periodo (anno-mese-giorno) | 2011-04-01 - 2015-03-31 |
# | ||||
---|---|---|---|---|
1 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | coordinator | 100˙000.00 |
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
'Translational control determines the rate at which mRNAs are synthesized into proteins; regulates biological processes ranging from apoptosis to memory; and shows deregulation in diseases such as fibrosis and cancer. In cancer, dysregulated translational control is associated with worse prognosis in most sold cancer. Despite this, integrated genome wide knowledge of translational control and its regulatory mechanisms is lacking. My new methods for data analysis and mechanistic discoveries allow, for the first time, efficient genome wide studies of translational control. By using all publicly available genome-wide data sets and these methods we will characterize the landscape of translational control by identifying genes and pathways that are regulated translationally; groups of genes that constitute functional translational modules and show co-regulation across many biological conditions; key genes that are highly connected (nodes) and under translational control; network structures that are regulated at the translational level; and mechanisms that mediate such regulation. This information will be used to compare many biological processes to generate an integrated perspective of translational control. Through functional experiments employing both gene specific and regulatory mechanism focused approaches we will link translational control, genes, mechanisms for regulation and biological processes to unravel a new level of understanding of translational control. Such knowledge will be applicable in future studies of how dysregulation of translational control contributes to human disease.'
When regulation of gene expression breaks down, the result can be cancer. A new statistical approach is tackling translational control on a genome-wide level.
"Metallic engineered nanomaterial in natural aquatic environments: data generation, management and integration into environmental exposure modelling"
Read MoreNucleo-cytoplasmic shuttling proteins and mechano-signalling in cardiac myocytes
Read MoreInternational Fellowship Program on Molecular Ultrafast Science and Technology
Read More