PANCLON

"Clonal analysis in pancreatic development, differentiation and carcinogenesis"

Coordinatore	FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III    more  Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 contact info Titolo: Ms. Nome: Dolores Cognome: Liebanes Email: send email Telefono: +3491 2246900 Fax: +3491 2246980
Nazionalità Coordinatore	Spain [ES]
Totale costo	230˙980 €
EC contributo	230˙980 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2013-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III  Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 contact info Titolo: Ms. Nome: Dolores Cognome: Liebanes Email: send email Telefono: +3491 2246900 Fax: +3491 2246980	ES (MADRID)	coordinator	230˙980.00

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 Obiettivo del progetto (Objective)

'The knowledge about pancreas development and the establishment of pancreatic cell lineages has exploded in recent years. These studies are important in developing strategies for regenerative medicine. On the other hand, pancreatic ductal adenocarcinoma (PDAC) is the tumor with the worst prognosis in humans: its incidence rate is equivalent to its mortality rate, with a median survival of less than 6 months. In this project, we will use retrospective clonal analysis to analyze the clonal structure of the mouse pancreas. Unlike other lineage tracing studies, the technique proposed allows the analysis of individual, low-frequency, clones. By doing this we pretend to dealwith questions such as clonality, clonal size and clonal variation in the embryonic pancreas. Moreover, we aim at developing strategies to analyze quantitatively the adult pancreas, not only in normal conditions but also in situations where the pancreas structure is disrupted by disease. We will thus use models of experimental pancreatitis. In the final step of this project, we pretend to set up the basis to use our clonal approach with murine PDAC murine models, using both genetic mouse models and carcinogen treatment. The work will impy two host groups with distinct and complementary expertise: developmentl biology and pancreas cancer biology. This kind of approach will become important in cancer research in the future in order to understand clonal evolution. The proposed project builds on the experience of the candidate and will allow him to acquire new expertise in cancer biology in order to establish his scientific career in the future.'