METABOLICREGULATORS
System-wide analysis of regulatory processes that mediate at the boarder of metabolome and proteome
| Coordinatore | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 1˙499˙996 € |
| EC contributo | 1˙499˙996 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2010-StG_20091118 |
| Funding Scheme | ERC-SG |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-06-01 - 2016-05-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | hostInstitution | 1˙499˙996.00 |
| 2 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | hostInstitution | 1˙499˙996.00 |
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Obiettivo del progetto (Objective)
'The metabolic network has a modular architecture, is robust to perturbations, and responds to biological stimuli. The balance of the network, and the passageway of network substructures to operate at different activity, requires intensive interactions between the metabolic network, the transcriptome and the proteome. However, the biochemical mechanisms monitoring the metabolic network are only barely understood. Changes in network activity are often mediated through so called reporter metabolites: general -network interconnecting cofactors and reaction substrates - and specific pathway intermediates. These metabolites bridge the gap between the small molecule and macromolecular universe of the cell. Here we propose combining systematic yeast genetics with targeted metabolomics and proteomics to understand mechanisms of metabolic regulation on a genome-scale level. In principle, we will elaborate multiple reaction monitoring (MRM) assays that facilitate quantification of enzymes and intermediates of selected metabolic pathways via liquid chromatography tandem mass spectrometry. The analysis will be performed on metabolic processes that influence aging; those will be analyzed and the results validated by chemical-genetic profiling and competitive lifespan experiments. The anticipated results will yield in a system-wide picture of interactions between the metabolome and regulatory components of the cell. Furthermore, it will identify novel genetic and biochemical interactions of the aging process. Understanding these mechanisms will stimulate new research directions in Systems Biology and support the development of therapeutic strategies against diseases of aging.'