ANTSAN

Analysis of the neural transcriptome of the sea anemone Nematostella vectensis

Coordinatore	UNI RESEARCH AS    more  Organization address address: THORMOHLENS GATE 55 city: BERGEN postcode: 5008 contact info Titolo: Mrs. Nome: Arne Sivert Cognome: Svinland Email: send email Telefono: +47 55 58 49 77 Fax: +47 55584971
Nazionalità Coordinatore	Norway [NO]
Totale costo	209˙979 €
EC contributo	209˙979 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IIF
Funding Scheme	MC-IIF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-05-05   -   2013-05-04

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNI RESEARCH AS  Organization address address: THORMOHLENS GATE 55 city: BERGEN postcode: 5008 contact info Titolo: Mrs. Nome: Arne Sivert Cognome: Svinland Email: send email Telefono: +47 55 58 49 77 Fax: +47 55584971	NO (BERGEN)	coordinator	209˙979.20

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 Obiettivo del progetto (Objective)

'The origin of simple nervous systems marks a key moment in animal evolution. To identify the genetic processes that underpinned this event, we need to study how neurogenesis occurs in early branching animal groups with simple non-centralised nervous systems. The Cnidaria (corals, sea anemones, jellyfish) are a particularly informative group for such investigations; however studies of cnidarian neural development have been hampered by a lack of appropriate tools for analysing gene function and visualising neurogenesis in these animals. The recent development of experimental assays and transgenic lineages in the cnidarian sea anemone Nematostella vectensis has addressed this problem and we are now able to examine neural development in this ancient phylum in exceptional detail. ANTSAN proposes to employ these advanced tools to identify and functionally characterise genes that underpin the critical process of establishing neural connectivity (e.g. axon guidance and synaptogenesis) in this species. To achieve this objective, N. vectensis neural cells will be isolated by performing fluorescence activated cell sorting on transgenic animals in which the nervous system is fluorescently labelled. The global gene expression in this cell population will then be documented via microarray analysis. This inventory of neural expressed genes will inform candidate gene selection for the functional studies of neural connectivity, and will also be compared to published datasets from other animals to identify genes with common roles in neural development across the animal kingdom. The research outcomes of ANTSAN will make a novel and significant contribution to our understanding of the essential factors involved in nervous system development, and of the earliest steps in nervous system evolution. ANTSAN may also contribute to studies of human neurological disorders, by identifying conserved genes with neural functions that have not yet been studied in biomedically relevant species.'