WNT FOR BRAIN

Transcriptional regulation of endothelial blood brain barrier differentiation by Wnt signaling

Coordinatore	IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Italy [IT]
Totale costo	2˙390˙200 €
EC contributo	2˙390˙200 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100317
Funding Scheme	ERC-AG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-08-01   -   2016-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE  Organization address address: "Via Adamello, 16" city: MILAN postcode: 20139 contact info Titolo: Mr. Nome: Carlo Cognome: Raimondi Cominesi Email: send email Telefono: +39 02 574303256 Fax: +39 02 574303231	IT (MILAN)	hostInstitution	2˙390˙200.00
2	IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE  Organization address address: "Via Adamello, 16" city: MILAN postcode: 20139 contact info Titolo: Prof. Nome: Elisabetta Cognome: Dejana Email: send email Telefono: +39 02 574303234 Fax: +39 02 574303231	IT (MILAN)	hostInstitution	2˙390˙200.00

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 Obiettivo del progetto (Objective)

'The brain vasculature has evolved to protect the central nervous system from the constantly changing milieu in the blood stream. Endothelial cells of brain capillaries form the so called blood brain barrier (BBB), an active permeability barrier and transport system which allows a selective passage of nutrients from blood to the nervous tissue. The continuous cross talk of endothelial cells, pericytes and nervous cells influences many vascular functions and determines and maintains the BBB characteristics after birth. Our limited knowledge of the nature of these signals prevents effective therapy of several diseases such as hemorrhagic stroke or brain edema. Furthermore, the development of tools to reversibly ¿open¿ the barrier would strongly improve drug delivery to the brain. In the present project we propose to tackle the problem by studying the transcriptional mechanisms which direct BBB differentiation. This strategy is based on preliminary work which shows that the cross talk between nervous cells and the endothelium is mediated by Wnt factors and downstream beta-catenin transcriptional activity. The understanding of the mechanism of action of Wnt signaling on brain endothelium may yield novel strategies and tools for modulating BBB permeability. The project is divided in three related objectives: 1) to define the mechanism of action and downstream partners of Wnt in brain angiogenesis and BBB differentiation; 2) to use this knowledge to develop an optimized BBB model in vitro and in vivo; 3) to test whether modulation of Wnt signaling may have a therapeutic impact in the regulation of BBB in pathological conditions.'