PVA DEVELOPMENT

"IDENTIFYING AND CHARACTERIZING REGULATORS OF PRIMORDIAL VASCULAR ADVENTITIA DEVELOPMENT, ORGANIZATION AND FUNCTION"

Coordinatore	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY    more  Organization address address: TECHNION CITY - SENATE BUILDING city: HAIFA postcode: 32000 contact info Titolo: Mr. Nome: Mark Cognome: Davison Email: send email Telefono: +972 4 829 3097 Fax: +972 4 823 2958
Nazionalità Coordinatore	Israel [IL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-09-01   -   2015-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY  Organization address address: TECHNION CITY - SENATE BUILDING city: HAIFA postcode: 32000 contact info Titolo: Mr. Nome: Mark Cognome: Davison Email: send email Telefono: +972 4 829 3097 Fax: +972 4 823 2958	IL (HAIFA)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Vascular development and function are complex processes of utmost importance to the organism involving numerous steps and cell types. One of the tissues participating in these processes is the vascular adventitia, the outermost layer of the vessel, mainly composed of connective tissue. Recently, with the association of the adventitia to a growing number of diseases, its activities have become slowly uncovered and shown to participate in a number of developmental and homeostatic processes. Despite this, the processes that regulate the development, organization and function of the primordial embryonic adventitia are still unknown. This proposal is aimed at addressing the mechanisms and key genes regulating primordial adventitia development, organization and function. It concentrates on uncovering the molecular mechanisms underlying the activities of Tbx5, the transcription factor associated with Holt Oram Syndrome. Significantly, Tbx5 deletion during limb outgrowth leads to novel phenotypes whereby vessels form but are then ruptured as a result of an abnormal primordial adventitia organization. We have uncovered two putative target genes mediating its activities – the tumor suppressor Lysyl oxidase and the oncogene beta-Catenin. We will take advantage of the developing limb as a proven model system that allows easy access and manipulations to address the different developmental and functional aspects of the proposal. Taken together, the proposed experiments will uncover and characterize novel processes required for the development and function of the adventitia. Due to the unique properties of the adventitia, this research will set a basis for testing the relationship between a tissue's organization and function. It will enhance the understanding of the pathways that participate in the development of pluripotent, connective and vascular tissues and potentially provide novel therapeutic targets for the treatment of diseases they are implicated in.'