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ULTRAPLACAD

ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ULTRAPLACAD project word cloud

Explore the words cloud of the ULTRAPLACAD project. It provides you a very rough idea of what is the project "ULTRAPLACAD" about.

diagnosis prognosis barriers cross imaging platform technologies improvement chips techniques industrial disciplinary approache competencies specificity circuit detection blood proven biomolecular automated modifications time dna resonance invasive assays suitable integrating biomarkers fluorescence manufacturing device readout pathological body chemical microscopy 1000 cancer mass ultrasensitive compact groups minimal microfluidic holding surface team sensitivity interventions chain platforms microrna performed disposable chip world plasmon colorectal minutes plasmonic reflect detect fluids enhanced respectively bimodal prototype limited fabricated full therapeutic autoantibodies fabrication functionalized spectroscopy first tumor lack inventor sensing nanostructures circulating direct spread ranging shown

Project "ULTRAPLACAD" data sheet

The following table provides information about the project.

Coordinator	NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS Organization address address: VIALE MEDAGLIE D'ORO 305 city: ROME postcode: 136 website: www.inbb.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.ultraplacad.eu
Total cost	6˙026˙455 €
EC max contribution	6˙026˙455 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2018-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS Organization address address: VIALE MEDAGLIE D'ORO 305 city: ROME postcode: 136 website: www.inbb.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROME)	coordinator	833˙487.00
2	AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH Organization address address: GIEFINGGASSE 4 city: WIEN postcode: 1210 website: http://www.ait.ac.at/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	972˙708.00
3	HORIBA FRANCE SAS HORIBA FRANCE SAS Organization address address: RUE DU CANAL 16-18 city: LONGJUMEAU postcode: 91160 website: www.jyhoriba.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LONGJUMEAU)	participant	646˙922.00
4	Teknologian tutkimuskeskus VTT Oy Teknologian tutkimuskeskus VTT Oy Organization address address: VUORIMIEHENTIE 3 city: Espoo postcode: 2150 website: www.vtt.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Espoo)	participant	630˙536.00
5	FUTURE DIAGNOSTICS SOLUTIONS BV FUTURE DIAGNOSTICS SOLUTIONS BV Organization address address: NIEUWEWEG 279 city: Wijchen postcode: 6603 BN website: www.future-diagnostics.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Wijchen)	participant	524˙375.00
6	ISTITUTI FISIOTERAPICI OSPITALIERI ISTITUTI FISIOTERAPICI OSPITALIERI Organization address address: VIA CHIANESI 53 city: ROMA postcode: 144 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	407˙375.00
7	GINOLIS OY GINOLIS OY Organization address address: AUTOMAATIOTIE 1 city: OULUNSALO postcode: 90460 website: www.ginolis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (OULUNSALO)	participant	403˙125.00
8	UNIVERSITEIT TWENTE UNIVERSITEIT TWENTE Organization address address: DRIENERLOLAAN 5 city: ENSCHEDE postcode: 7522 NB website: www.utwente.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	participant	343˙750.00
9	USTAV FOTONIKY A ELEKTRONIKY AV CR V.V.I. USTAV FOTONIKY A ELEKTRONIKY AV CR V.V.I. Organization address address: KOBYLISY CHABERSKA 57 city: PRAHA 8 postcode: 182 51 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 8)	participant	313˙125.00
10	UNIVERSITAET SIEGEN UNIVERSITAET SIEGEN Organization address address: ADOLF REICHWEIN STRASSE 2A city: SIEGEN postcode: 57076 website: www.uni-siegen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (SIEGEN)	participant	307˙300.00
11	SCRIBA NANOTECNOLOGIE SRL SCRIBA NANOTECNOLOGIE SRL Organization address address: VIA DI CORTICELLA 183/8 city: BOLOGNA postcode: 40128 website: www.scriba-nanotec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	270˙250.00
12	UNIVERSITA DEGLI STUDI DI FERRARA UNIVERSITA DEGLI STUDI DI FERRARA Organization address address: VIA ARIOSTO 35 city: FERRARA postcode: 44121 website: www.unife.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FERRARA)	participant	213˙750.00
13	AMIRES SRO AMIRES SRO Organization address address: STAVITELSKA 1099/6 city: PRAHA 6 postcode: 160 00 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 6)	participant	159˙750.00

Map

Project objective

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers.

The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.

Deliverables

List of deliverables.
End user workshop organized and feedback collected	Other	2019-10-04 10:05:59
Webpage of the project fully operational	Other	2019-10-04 10:05:58
Development of the dissemination and communication strategy and project brochure & templates	Documents, reports	2019-10-04 10:05:58

Take a look to the deliverables list in detail: detailed list of ULTRAPLACAD deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Roberta Dâ€™Agata, Maria Giuffrida, Giuseppe Spoto Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis published pages: 1951, ISSN: 1420-3049, DOI: 10.3390/molecules22111951	Molecules 22/11	2019-10-04
2018	Elisabetta Dâ€™Aversa, Giulia Breveglieri, Patrizia Pellegatti, Giovanni Guerra, Roberto Gambari, Monica Borgatti Non-invasive fetal sex diagnosis in plasma of early weeks pregnants using droplet digital PCR published pages: , ISSN: 1076-1551, DOI: 10.1186/s10020-018-0016-7	Molecular Medicine 24/1	2019-10-04
2018	Matteo Allegretti, Beatrice Casini, Chiara Mandoj, Stefania Benini, Laurent Alberti, Mariangela Novello, Elisa Melucci, Laura Conti, Renato Covello, Edoardo Pescarmona, Giuseppe Maria Milano, Alessio Annovazzi, Vincenzo Anelli, Virginia Ferraresi, Roberto Biagini, Patrizio Giacomini Precision diagnostics of Ewingâ€™s sarcoma by liquid biopsy: circulating EWS-FLI1 fusion transcripts published pages: 175883591877433, ISSN: 1758-8359, DOI: 10.1177/1758835918774337	Therapeutic Advances in Medical Oncology 10	2019-10-04
2017	Barbora Å paÄkovÃ¡, N. Scott Lynn, JiÅ™Ã SlabÃ½, Hana Å ÃpovÃ¡, JiÅ™Ã Homola A Route to Superior Performance of a Nanoplasmonic Biosensor: Consideration of Both Photonic and Mass Transport Aspects published pages: 1019-1025, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.7b01319	ACS Photonics 5/3	2019-10-04
2016	Finotti, A;Â Tremante, E;Â Gasparello, J;Â Fabbri, EÂ ;Â Bianchi, N;Â Allegretti, MÂ ;Â Giacomini, P;Â Gambari, R A liquid biopsy model: circulating miRNA levels in mice bearing colorectal carcinoma tumor xenografts published pages: Vol 38, Supp 1, , ISSN: , DOI:	International Journal of Molecular Medicine	2019-10-04
2018	Agnes T. Reiner, Stefan Fossati, Jakub Dostalek Biosensor platform for parallel surface plasmon-enhanced epifluorescence and surface plasmon resonance detection published pages: 594-601, ISSN: 0925-4005, DOI: 10.1016/j.snb.2017.10.116	Sensors and Actuators B: Chemical 257	2019-10-04
2018	Matteo Allegretti, Alessandra Fabi, Simonetta Buglioni, Aline Martayan, Laura Conti, Edoardo Pescarmona, Gennaro Ciliberto, Patrizio Giacomini Tearing down the walls: FDA approves next generation sequencing (NGS) assays for actionable cancer genomic aberrations published pages: , ISSN: 1756-9966, DOI: 10.1186/s13046-018-0702-x	Journal of Experimental & Clinical Cancer Research 37/1	2019-10-04
2018	Christian Petri, Ulrich Jonas Synthesis and Characterization of Novel Photocrosslinkable Poly(2-Oxazoline)-Based Hydrogel Systems for the Application as Biosensor Matrix published pages: , ISSN: , DOI:		2019-10-04
2018	J. Gasparello, A. Finotti, R. Gambari Novel trends in microRNA based theranostics published pages: , ISSN: , DOI:		2019-10-04
2018	N. Scott Lynn, JiÅ™Ã Homola Microfluidic Analyte Transport to Nanorods for Photonic and Electrochemical Sensing Applications published pages: 12031-12036, ISSN: 0947-6539, DOI: 10.1002/chem.201802757	Chemistry - A European Journal 24/46	2019-10-04
2018	Janneke Veerbeek, Raymond Steen, Wouter Vijselaar, W. Frederik Rurup, SaÅ¡a Korom, Andrea Rozzi, Roberto Corradini, Loes Segerink, Jurriaan Huskens Selective Functionalization with PNA of Silicon Nanowires on Silicon Oxide Substrates published pages: 11395-11404, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b02401	Langmuir 34/38	2019-10-04
2018	Andrea Rozzi, Roberto Corradini Advanced PNA-based sensor systems published pages: , ISSN: , DOI:		2019-10-04
2018	N. G. Quillis, N. Sharma, S. Fossati, W. Knoll, J. Dostalek Responsive polymer networks and brushes for active plasmonics published pages: , ISSN: , DOI:	Polymer and Biopolymer Brushes: Fundamentals and Applications in Materials Science and Biotechnology	2019-10-04
2018	Noemi Bellassai, Almudena Marti, Giuseppe Spoto, Jurriaan Huskens Low-fouling, mixed-charge poly- l -lysine polymers with anionic oligopeptide side-chains published pages: , ISSN: 2050-7518, DOI: 10.1039/C8TB01619D	Journal of Materials Chemistry B	2019-10-04
2018	Jessica Gasparello, Matteo Allegretti, Elisa Tremante, Enrica Fabbri, Carla Azzurra Amoreo, Paolo Romania, Elisa Melucci, Katia Messana, Monica Borgatti, Patrizio Giacomini, Roberto Gambari, Alessia Finotti Liquid biopsy in mice bearing colorectal carcinoma xenografts: gateways regulating the levels of circulating tumor DNA (ctDNA) and miRNA (ctmiRNA) published pages: , ISSN: 1756-9966, DOI: 10.1186/s13046-018-0788-1	Journal of Experimental & Clinical Cancer Research 37/1	2019-10-04
2018	Christian Stelling, Stefan Fossati, Jakub Dostalek, Markus Retsch Surface plasmon modes of nanomesh-on-mirror nanocavities prepared by nanosphere lithography published pages: 17983-17989, ISSN: 2040-3364, DOI: 10.1039/C8NR05499A	Nanoscale 10/37	2019-10-04
2018	Noemi Bellassai, Giuseppe Spoto Surface Plasmon Resonance Imaging Biosensors for Cancer Diagnosis: Detection of Circulating Tumor DNA published pages: , ISSN: , DOI:		2019-10-04
2018	Jacopo Movilli, Andrea Rozzi, Roberto Ricciardi, Roberto Corradini, Jurriaan Huskens Control of Probe Density at DNA Biosensor Surfaces Using Poly( l -lysine) with Appended Reactive Groups published pages: , ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00733	Bioconjugate Chemistry	2019-10-04
2018	Alessia Finotti, Matteo Allegretti, Jessica Gasparello, Patrizio Giacomini, Demetrios Spandidos, Giuseppe Spoto, Roberto Gambari Liquid biopsy and PCR-free ultrasensitive detection systems in oncology (Review) published pages: , ISSN: 1019-6439, DOI: 10.3892/ijo.2018.4516	International Journal of Oncology	2019-10-04
2018	Papi C, A. Finotti, R. Gambari, J Gasparello Strategie innovative per lo sviluppo di nuovi approcci teranostici: studio del profilo di espressione di microRNA in patologie genetiche e tumorali mediante NGS e ddPCR published pages: , ISSN: , DOI:		2019-10-04
2016	G. Donelli, A. Finotti, R. Gambari A liquid biopsy model in mice bearing colorectal carcinoma xenografts: analysis of tumor derived microRNAs published pages: , ISSN: , DOI:		2019-10-04
2016	Alex Manicardi, Alessandro Bertucci, Andrea Rozzi, Roberto Corradini A Bifunctional Monomer for On-Resin Synthesis of Polyfunctional PNAs and Tailored Induced-Fit Switching Probes published pages: 5452-5455, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b02363	Organic Letters 18/21	2019-10-04
2016	Simone Hageneder, Martin Bauch, Jakub Dostalek Plasmonically amplified bioassay â€“ Total internal reflection fluorescence vs. epifluorescence geometry published pages: 225-231, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2016.05.023	Talanta 156-157	2019-10-04
2016	Roberto Gambari, Eleonora Brognara, Demetrios Spandidos, Enrica Fabbri Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Îew trends in the development of miRNA therapeutic strategies in oncology (Review) published pages: 5-32, ISSN: 1019-6439, DOI: 10.3892/ijo.2016.3503	International Journal of Oncology 49(1)	2019-10-04
2017	Raquel Mejia-Ariza, Jessica Rosselli, Christian Breukers, Alex Manicardi, Leon W. M. M. Terstappen, Roberto Corradini, Jurriaan Huskens DNA Detection by Flow Cytometry using PNA-Modified Metal-Organic Framework Particles published pages: 4180-4186, ISSN: 0947-6539, DOI: 10.1002/chem.201605803	Chemistry - A European Journal 23/17	2019-10-04
2017	Massimiliano Donato Verona, Vincenzo Verdolino, Ferruccio Palazzesi, Roberto Corradini Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics published pages: 42799, ISSN: 2045-2322, DOI: 10.1038/srep42799	Scientific Reports 7	2019-10-04
2017	Roberta D\'Agata, Pasquale Palladino, Giuseppe Spoto Streptavidin-coated gold nanoparticles: critical role of oligonucleotides on stability and fractal aggregation published pages: 1-11, ISSN: 2190-4286, DOI: 10.3762/bjnano.8.1	Beilstein Journal of Nanotechnology 8	2019-10-04

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