ImmunoAgeing SIGNED
An integrated approach to dissect determinants, risk factors and pathways of ageing of the immune system.
Total Cost €
0EC-Contrib. €
0Partnership
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0ImmunoAgeing project word cloud
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Project "ImmunoAgeing" data sheet
The following table provides information about the project.
| Coordinator |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | http://www.immunoageing.eu/ |
| Total cost | 5˙850˙000 € |
| EC max contribution | 5˙850˙000 € (100%) |
| Programme |
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease) |
| Code Call | H2020-PHC-2014-two-stage |
| Funding Scheme | RIA |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-05-01 to 2019-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CONSIGLIO NAZIONALE DELLE RICERCHE | IT (ROMA) | coordinator | 2˙514˙062.00 |
| 2 | THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE | UK (CAMBRIDGE) | participant | 2˙227˙855.00 |
| 3 | UNIVERSITAET INNSBRUCK | AT (INNSBRUCK) | participant | 700˙000.00 |
| 4 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | participant | 208˙082.00 |
| 5 | ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU | IT (SIENA) | participant | 200˙000.00 |
Map
Project objective
Age-related changes in the immune system, also known as ‘immunosenescence’, have a huge detrimental impact on the health of our ageing populations. However, the extent and mechanisms of the changes, and thus possible routes to prevention or alleviation, are largely unknown. We propose to analyse immunosenescence with unprecedented resolution by determining in large cohorts of volunteers the changes with age in circulating levels of ~140 subtypes of immune system cells and ~25 immune molecules, including cytokines and antibodies. We will also quantify age-related immune dysfunction, and notably autoreactivity, by determining the specificity and level of key circulating autoantibodies and their correlation with contractions in the B & T cell repertoire in our large general population ageing cohorts. Underlying genetic and major environmental factors -- including life style choices like smoking, diet, alcohol intake and, physical activity as well as transmissible viral infections -- will be systematically analysed. The analyses will build on our studies on levels of immune system cell subsets and inflammatory biomarkers in genetically well characterized population cohorts, and will be followed up by examining sorted circulating cells for ageing-related shifts in transcriptional profiles and function. For these targetted experiments, our focus,will be on cell types that show the greatest changes with age and/or are most critical for immune responsiveness; and from volunteers selected based on their genetic and epidemiological exposure profiles. Studies will be facilitated by complementary expertise of the participating centres, capitalising on unique bioresources. Overall, the advances in knowledge should better elucidate pathways of immunosenescence, reveal new biomarkers for early diagnosis of immune dysfunction, and point to target cells and molecules that can be supplemented or activated for eventual prevention or alleviation of ageing-related immune dysfunction.
Deliverables
| Website development and management | Websites, patent fillings, videos etc. | 2019-12-17 15:18:18 |
Take a look to the deliverables list in detail: detailed list of ImmunoAgeing deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Andreas Meryk, Luca Pangrazzi, Magdalena Hagen, Florian Hatzmann, Brigitte Jenewein, Bojana Jakic, Natascha Hermann-Kleiter, Gottfried Baier, Juulia Jylhävä, Mikko Hurme, Klemens Trieb, Beatrix Grubeck-Loebenstein Fcμ receptor as a Costimulatory Molecule for T Cells published pages: 2681-2691.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.02.024 |
Cell Reports 26/10 | 2019-12-17 |
| 2018 |
Stella Lukas Yani, Michael Keller, Franz Leonard Melzer, Birgit Weinberger, Luca Pangrazzi, Sieghart Sopper, Klemens Trieb, Monia Lobina, Valeria Orrù, Edoardo Fiorillo, Francesco Cucca, Beatrix Grubeck-Loebenstein CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01201 |
Frontiers in Immunology 9 | 2019-12-17 |
| 2017 |
Maristella Steri, Valeria Orrù, M. Laura Idda, Maristella Pitzalis, Mauro Pala, Ilenia Zara, Carlo Sidore, Valeria Faà , Matteo Floris, Manila Deiana, Isadora Asunis, Eleonora Porcu, Antonella Mulas, Maria G. Piras, Monia Lobina, Sandra Lai, Mara Marongiu, Valentina Serra, Michele Marongiu, Gabriella Sole, Fabio Busonero, Andrea Maschio, Roberto Cusano, Gianmauro Cuccuru, Francesca Deidda, Fausto Poddie, Gabriele Farina, Mariano Dei, Francesca Virdis, Stefania Olla, Maria A. Satta, Mario Pani, Alessandro Delitala, Eleonora Cocco, Jessica Frau, Giancarlo Coghe, Lorena Lorefice, Giuseppe Fenu, Paola Ferrigno, Maria Ban, Nadia Barizzone, Maurizio Leone, Franca R. Guerini, Matteo Piga, Davide Firinu, Ingrid Kockum, Izaura Lima Bomfim, Tomas Olsson, Lars Alfredsson, Ana Suarez, Patricia E. Carreira, Maria J. Castillo-Palma, Joseph H. Marcus, Mauro Congia, Andrea Angius, Maurizio Melis, Antonio Gonzalez, Marta E. Alarcón Riquelme, Berta M. da Silva, Maurizio Marchini, Maria G. Danieli, Stefano Del Giacco, Alessandro Mathieu, Antonello Pani, Stephen B. Montgomery, Giulio Rosati, Jan Hillert, Stephen Sawcer, Sandra D’Alfonso, John A. Todd, John Novembre, Gonçalo R. Abecasis, Michael B. Whalen, Maria G. Marrosu, Alessandra Meloni, Serena Sanna, Myriam Gorospe, David Schlessinger, Edoardo Fiorillo, Magdalena Zoledziewska, Francesco Cucca Overexpression of the Cytokine BAFF and Autoimmunity Risk published pages: 1615-1626, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1610528 |
New England Journal of Medicine 376/17 | 2019-12-17 |
| 2017 |
Luca Pangrazzi, Erin Naismith, Andreas Meryk, Michael Keller, Brigitte Jenewein, Klemens Trieb, Beatrix Grubeck-Loebenstein Increased IL-15 Production and Accumulation of Highly Differentiated CD8+ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus published pages: 715, ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00715 |
Frontiers in Immunology 8 | 2019-12-17 |
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