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CARBALIVE SIGNED

Clinical evaluation of carbons of controlled porosity as a new therapeutic for the treatment of liver cirrhosis and non-alcoholic fatty liver disease.

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

CARBALIVE project word cloud

Explore the words cloud of the CARBALIVE project. It provides you a very rough idea of what is the project "CARBALIVE" about.

absorbed million burden deaths central confirm pathogenesis innovative nanoporous endotoxins return 15 progression infection economic cheap ready modulation rate safe strategy alcohol academic accounting enhanced resistance gut modulates productivity 170 carbalive prevention implicated therapy antibiotic feasibility validation clinical complications organisms communicable survival liver successful population alarming causes unmet resistant viral models animal patients europeans chronic ageing life fatty private obesity 29 additional carbon antibiotics cirrhosis efficacy industrial trials public translocation bacterial safety 8bn poorly disease amenable trl quality hepatitis continued reduce prevent investment patented treatment recurrent

Project "CARBALIVE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.carbalive.eu/
Total cost	6˙438˙786 €
EC max contribution	5˙913˙079 € (92%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙281˙528.00
2	YAQRIT LIMITED YAQRIT LIMITED Organization address address: THE NETWORK BUILDING 97 TOTTENHAM COURT ROAD city: LONDON postcode: W1T 4TP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	899˙748.00
3	ALPHA BIORESEARCH SL ALPHA BIORESEARCH SL Organization address address: PASEO DE LA CASTELLANA 163 PLANTA 2 PUERTA IZ city: MADRID postcode: 28046 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	764˙535.00
4	MAST CARBON INTERNATIONAL LTD MAST CARBON INTERNATIONAL LTD Organization address address: JAYS CLOSE VIABLES city: Basingstoke postcode: RG22 4BA website: www.mastcarbon.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	participant	398˙495.00
5	FACULDADE DE MEDICINA DA UNIVERSIDADE DE LISBOA FACULDADE DE MEDICINA DA UNIVERSIDADE DE LISBOA Organization address address: AVENIDA PROFESSOR EGAS MONIZ, EDIFICIO HOSPITAL SANTA MARIA city: LISBOA postcode: 1649-028 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	307˙182.00
6	ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ASSISTANCE PUBLIQUE HOPITAUX DE PARIS Organization address address: 3 AVENUE VICTORIA city: PARIS postcode: 75000 website: http://www.aphp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	297˙016.00
7	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	292˙056.00
8	ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Organization address address: VIA ZAMBONI 33 city: BOLOGNA postcode: 40126 website: www.unibo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	290˙506.00
9	FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Organization address address: PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA city: BARCELONA postcode: 8035 website: http://www.vhir.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	289˙320.00
10	SERVICIO MADRILENO DE SALUD SERVICIO MADRILENO DE SALUD Organization address address: PLAZA CARLOS TRIAS BERTRAN 7 city: MADRID postcode: 28020 website: http://cort.as/10Yf contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	278˙148.00
11	UNIVERSITA DEGLI STUDI DI PADOVA UNIVERSITA DEGLI STUDI DI PADOVA Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 website: www.unipd.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	participant	261˙399.00
12	EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF) EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF) Organization address address: TRAVESSERA DE GRACIA 11, 7TH FLOOR city: BARCELONA postcode: 8021 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	238˙250.00
13	UNIVERSITY OF BRIGHTON UNIVERSITY OF BRIGHTON Organization address address: LEWES ROAD MITHRAS HOUSE city: BRIGHTON postcode: BN2 4AT website: www.brighton.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRIGHTON)	participant	179˙954.00
14	A2F ASSOCIATES LIMITED A2F ASSOCIATES LIMITED Organization address address: 7 LAUREATE PADDOCKS city: NEWMARKET postcode: CB8 0AP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWMARKET)	participant	134˙936.00
15	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	0.00

Map

Project objective

Chronic liver disease affects about 29-million Europeans accounting for about 170,000 deaths at a cost of around €15.8bn. This chronic non-communicable disease is increasing at an alarming rate due to increasing European obesity, alcohol use and ageing. The three main causes of the disease; alcohol, fatty liver and viral hepatitis are amenable to prevention and treatment. Gut-derived endotoxins and bacterial translocation are central factors implicated in the pathogenesis of fatty liver disease and, the development and progression of cirrhosis. In cirrhosis, current state-of-the-art therapy to prevent recurrent complications of advanced cirrhosis is to use poorly absorbed antibiotics but long-term antibiotic therapy has problems associated with bacterial resistance, infection with resistant organisms and the cost. Treatment of fatty liver and modulation of bacterial translocation in early cirrhosis to prevent complications is an unmet need. Our academic-industrial consortium has developed a novel, patented, safe and cheap nanoporous carbon that modulates the effects of bacterial translocation in animal models of liver disease. Our feasibility studies demonstrate that this product advances the current state-of-the-art, is a TRL 4/5 and is now ready for validation through clinical trials. We propose to investigate the safety and efficacy of this novel nanoporous carbon in patients with fatty liver disease and cirrhosis. If successful, we will be able to confirm an innovative, cost-effective and novel strategy for the management of this chronic disease in a European population. Exploitation of the results of the CARBALIVE project will support the continued development of this carbon through additional private and public sector investment. The use of this innovative therapy is expected to reduce the economic burden of the disease in Europe, allow patients to achieve enhanced quality of life, improve survival, and allow many patients to return to economic productivity.

Deliverables

List of deliverables.
Project website and social media accounts	Other	2020-04-09 08:15:12

Take a look to the deliverables list in detail: detailed list of CARBALIVE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	AgustÃn Albillos, Andrea de Gottardi, MarÃa Rescigno The gut-liver axis in liver disease: Pathophysiological basis for therapy published pages: , ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.10.003	Journal of Hepatology	2020-04-09
2017	Reiner Wiest, Agustin Albillos, Michael Trauner, Jasmohan S. Bajaj, Rajiv Jalan Targeting the gut-liver axis in liver disease published pages: 1084-1103, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.05.007	Journal of Hepatology 67/5	2020-04-09

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The information about "CARBALIVE" are provided by the European Opendata Portal: CORDIS opendata.