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iHealth-T2D SIGNED

Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

iHealth-T2D project word cloud

Explore the words cloud of the iHealth-T2D project. It provides you a very rough idea of what is the project "iHealth-T2D" about.

population world waist will thereby session impaired diabetic sessions socio strategy group asians pakistan family prevention lifestyle members scalable 30 diagnosis men circumference scalability modification south followed power 734 endpoints primary glucose preventing intervention poor sites secondary complete index cluster lanka billion physician evaluation worker hba1c 22 uk healthy worldwide predicted clinical 100cm utility weight gt epidemic 120 health 80 usual treatment compare 24 quarter risk diet economic annually 60 tolerance endpoint physical diabetes randomised active burden t2d women care asian obesity locations n amongst effectiveness sri vs equitable coupled gender 0 base screening reverse onset intensive community limited promotion prediabetes india 600 efficient central ge trial

Project "iHealth-T2D" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.ihealth-t2d.eu
Total cost	3˙614˙083 €
EC max contribution	3˙614˙083 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-HCO-2014
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙386˙972.00
2	LONDON NORTH WEST HEALTHCARE NATIONAL HEALTH SERVICE TRUST LONDON NORTH WEST HEALTHCARE NATIONAL HEALTH SERVICE TRUST Organization address address: WATFORD ROAD city: HARROW MIDDLESEX postcode: HA1 3UJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (HARROW MIDDLESEX)	participant	749˙537.00
3	DEVKI DEVI FOUNDATION SOCIETY DEVKI DEVI FOUNDATION SOCIETY Organization address address: PRESS ENCLAVE ROAD SAKET 2 city: NEW DELHI postcode: 110017 website: www.maxhealthcare.in contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (NEW DELHI)	participant	247˙050.00
4	UNIVERSITY OF SURREY UNIVERSITY OF SURREY Organization address address: Stag Hill city: GUILDFORD postcode: GU2 7XH website: www.surrey.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GUILDFORD)	participant	244˙233.00
5	SERVICES INSTITUTE OF MEDICAL SCIENCES SERVICES INSTITUTE OF MEDICAL SCIENCES Organization address address: JAIL ROAD OPPOSITE RACE COURSE PARK city: Lahore postcode: 54000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PK (Lahore)	participant	176˙900.00
6	OULUN YLIOPISTO OULUN YLIOPISTO Organization address address: PENTTI KAITERAN KATU 1 city: OULU postcode: 90014 website: www.oulu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (OULU)	participant	166˙990.00
7	UNIVERSITY OF COLOMBO UNIVERSITY OF COLOMBO Organization address address: 94 CUMARATUNGA MUNIDASA MAWATHA city: COLOMBO WESTERN PROVINCE postcode: 300 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LK (COLOMBO WESTERN PROVINCE)	participant	155˙550.00
8	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	146˙250.00
9	UNIVERSITY OF KELANIYA UNIVERSITY OF KELANIYA Organization address address: DALUGAMA city: KELANIYA postcode: n.a. website: www.med.kln.ac.lk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LK (KELANIYA)	participant	121˙237.00
10	PUNJAB INSTITUTE OF CARDIOLOGY (PIC) LAHORE PUNJAB INSTITUTE OF CARDIOLOGY (PIC) LAHORE Organization address address: JAIL ROAD GHOUS UL AZAM city: LAHORE PUNJAB postcode: 54000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PK (LAHORE PUNJAB)	participant	113˙612.00
11	INSTITUTE FOR HEALTH POLICY INSTITUTE FOR HEALTH POLICY Organization address address: 72 PARK STREET city: COLOMBO postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LK (COLOMBO)	participant	105˙750.00
12	EALING HOSPITAL NHS TRUST EALING HOSPITAL NHS TRUST Organization address address: UXBRIDGE ROAD city: SOUTHALL postcode: UB1 3HW website: www.ealinghospital.nhs.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SOUTHALL)	participant	0.00

Map

Project objective

South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden. We will complete a cluster-randomised clinical trial at 120 locations across India, Pakistan, Sri Lanka and the UK. We will compare family-based intensive lifestyle modification (22 health promotion sessions from a community health worker, active group, N=60 sites) vs usual care (1 session, control group, N=60 sites) for prevention of T2D, amongst 3,600 non-diabetic South Asian men and women with central obesity (waist≥100cm) and/or prediabetes (HbA1c≥6.0%). Participants will be followed annually for 3 years. The primary endpoint will be new-onset T2D (physician diagnosis on treatment or HbA1c≥6.0%, predicted N~734 over 3 years). Secondary endpoints will include waist and weight in the index case and family members. Our study has 80% power to identify a reduction in T2D risk with family-based intervention vs usual care of: 30% in South Asians with central obesity; 24% in South Asians with prediabetes; and 24% overall. Health economic evaluation will determine cost-effectiveness of family based lifestyle modification for prevention of T2D amongst South Asians with central obesity and / or prediabetes. The impact of gender and socio-economic factors on clinical utility and cost-effectiveness will be investigated. Our results will determine whether screening by waist circumference and/or HbA1c, coupled with intervention by family-based lifestyle modification, is an efficient, effective and equitable strategy for prevention of T2D in South Asians. Our findings will thereby provide a robust evidence base for scalable community-wide approaches to reverse the epidemic of T2D amongst the >1.5 billion South Asians worldwide.

Deliverables

List of deliverables.
Web Dissemination	Websites, patent fillings, videos etc.	2020-03-11 10:38:00
Targeted Dissemination	Other	2020-03-11 11:50:37
Final Reports on Outcomes Data	Documents, reports	2020-03-11 11:50:39
Health Economic Analysis	Documents, reports	2020-03-11 10:38:01
Report on Intervention	Documents, reports	2019-09-02 09:23:07
Report on Recruitment	Documents, reports	2019-09-02 09:23:07
Project Website	Websites, patent fillings, videos etc.	2019-09-02 09:23:07

Take a look to the deliverables list in detail: detailed list of iHealth-T2D deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Mirthe Muilwijk1, Marie Loh2,3, Sara Mahmood4, Saranya Palaniswamy3,5, Samreen Siddiqui6, Wnurinham Silva3, Gary S. Frost7, Heather M. Gage8, Marjo-Riitta Jarvelin3,5,9,10, Ravindra P. Rannan-Eliya11, Sajjad Ahmed12, Sujeet Jha6, Anuradhani Kasturiratne13, Prasad Katulanda14, Khadija I. Khawaja4, Jaspal S. Kooner15,16, Ananda R. Wickremasinghe13, Irene G.M. van Valkengoed1**, John C. Chambers2,3 The iHealth-T2D study: Statistical analysis plan for a cluster randomised controlled trial with intensive family-based lifestyle modification programme to reduce type 2 diabetes risk amongst South Asians published pages: , ISSN: , DOI:	Trials	2020-03-05

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