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EDIT SIGNED

Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma.

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

EDIT project word cloud

Explore the words cloud of the EDIT project. It provides you a very rough idea of what is the project "EDIT" about.

cancers consequent clinical gnrs validation weekly revolutionize therapy disease denominator gold hoc heat breast cancer extracellular edit combining colorectal platforms generating quality imaging resolution onset preclinical utilized detection plasmonic endless treatments cells crave cis termed health specificity nanotechnologies ultrasound bca progression mechanical area requiring elastography nanomedicine neoplastic nanoscale earlier ways sensors eradication poor biomarker prevention platform follow prognosis engineered carcinoma 3d bladder programs transformative tumor visualization solid ad detect matrix modification invasive prostate exploits designed protocols photoacoustic patient relapse pathologies structural thermal photo intravesical highest aggressive tumors combined therapeutic ionizing situ instilled ecm life few devastating effectors nanorods outcomes transdisciplinary local public effector releasing pave organ sensitivity introduction sensing antennas performance definition unmet

Project "EDIT" data sheet

The following table provides information about the project.

Coordinator	OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	https://www.edit-h2020.eu/
Total cost	4˙317˙160 €
EC max contribution	4˙317˙160 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-10-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	1˙146˙963.00
2	FUJIFILM SONOSITE BV FUJIFILM SONOSITE BV Organization address address: JOOP GEESINKWEG 140 city: AMSTERDAM postcode: 1114 AB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	681˙625.00
3	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	480˙125.00
4	ASCEND TECHNOLOGIES LIMITED ASCEND TECHNOLOGIES LIMITED Organization address address: 2 VENTURE ROAD, SOUTHAMPTON SCIENCE PARK city: SOUTHAMPTON postcode: SO16 7NP website: www.ascendtechnologies.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SOUTHAMPTON)	participant	400˙500.00
5	ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Organization address address: VIA ZAMBONI 33 city: BOLOGNA postcode: 40126 website: www.unibo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	374˙350.00
6	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	368˙437.00
7	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	350˙225.00
8	LIME TECHNOLOGY IKE LIME TECHNOLOGY IKE Organization address address: DODONIS 9 city: IOANNINA postcode: 45221 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IOANNINA)	participant	298˙570.00
9	OSM-DAN LTD OSM-DAN LTD Organization address address: 19 PRO NEEMAN YUVAL ST city: REHOVOT postcode: 7608665 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	216˙363.00

Map

Project objective

Unmet clinical needs in the management of bladder cancer (BCa) are the prevention of tumor onset, relapse and progression, and therapy of the aggressive carcinoma in situ (Cis), requiring weekly treatments and endless follow-up, with a consequent poor quality of life and the highest cost per patient among all cancers. Therefore, public health programs crave for early BCa detection protocols, to improve performance in the management of this devastating disease. Here we propose an advanced transformative technology termed EDIT combining a novel high-resolution ultrasound elastography and photoacoustic imaging on the bladder instilled with targeted plasmonic gold sensors. EDIT approach exploits the structural and mechanical properties of the bladder extracellular matrix (ECM) as a unique biomarker of the early onset/progression/relapse of carcinoma, through engineered novel gold nanorods (GNRs) used as intravesical photoacoustic antennas targeted at the ECM, generating an ad hoc visualization platform. GNRs will be further utilized as heat-releasing effectors at nanoscale for targeted cancer photo-thermal therapy. EDIT is designed to detect pre-neoplastic area and eradication of local areas at few cells resolution with high sensitivity and specificity. We bring together a multi and transdisciplinary consortium capable to develop non-invasive and non-ionizing novel technology and preclinical validation for early prognosis of BCa and therapeutic nanomedicine against bladder Cis. Outcomes of EDIT will revolutionize the management of BCa with the introduction of sensing and effector nanotechnologies combined with non-invasive organ imaging with high resolution/definition by 3D ultrasound and photoacoustic imaging. Structural and mechanical modification of the ECM is a common denominator for invasive breast, colorectal, prostate and bladder cancers. EDIT platforms will also pave the ways for the earlier management of other bladder-related pathologies and solid tumors.

Deliverables

List of deliverables.
First plan for dissemination and exploitation (using and disseminating the foreground (=PUDF))	Documents, reports	2020-02-12 17:34:02
Project website and logo	Websites, patent fillings, videos etc.	2020-02-12 17:34:07

Take a look to the deliverables list in detail: detailed list of EDIT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Mark Owyong, Jonathan Chou, Renske JE van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard, Dalit Talmi-Frank, Inna Solomonov, Charlotte Koopman, Elin Hadler-Olsen, Mark Headley, Charlene Lin, Chih-Yang Wang, Irit Sagi, Zena Werb, Vicki Plaks MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy published pages: e201800226, ISSN: 2575-1077, DOI: 10.26508/lsa.201800226	Life Science Alliance 2/6	2020-04-15
2020	Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2020.00480	Frontiers in Immunology 11	2020-04-15
2019	Francesca Nardelli, Michela Ghitti, Giacomo Quilici, Alessandro Gori, Qingqiong Luo, Andrea Berardi, Angelina Sacchi, Matteo Monieri, Greta Bergamaschi, Wolfgang Bermel, Fuxiang Chen, Angelo Corti, Flavio Curnis, Giovanna Musco A stapled chromogranin A-derived peptide is a potent dual ligand for integrins Î±vÎ²6 and Î±vÎ²8 published pages: , ISSN: 1359-7345, DOI: 10.1039/c9cc08518a	Chemical Communications	2019-12-16
2019	Alakesh Das, Vishnu Mohan, Venkat Raghavan Krishnaswamy, Inna Solomonov, Irit Sagi Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression published pages: , ISSN: , DOI: 10.1007/s10555-019-09813-5	Cancer and Metastasis Reviews	2019-12-16
2019	Mirko Maturi, Erica Locatelli, Ilaria Monaco, Mauro Comes Franchini Current concepts in nanostructured contrast media development for in vivo photoacoustic imaging published pages: 1746-1775, ISSN: 2047-4830, DOI: 10.1039/c8bm01444b	Biomaterials Science 7/5	2019-10-01

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The information about "EDIT" are provided by the European Opendata Portal: CORDIS opendata.

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