DENOVOSTEM SIGNED
DE NOVO GENERATION OF SOMATIC STEM CELLS: REGULATION AND MECHANISMS OF CELL PLASTICITY
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the DENOVOSTEM project. It provides you a very rough idea of what is the project "DENOVOSTEM" about.
Project "DENOVOSTEM" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITA DEGLI STUDI DI PADOVA
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 2˙498˙934 € |
| EC max contribution | 2˙498˙934 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITA DEGLI STUDI DI PADOVA | IT (PADOVA) | coordinator | 2˙239˙422.00 |
| 2 | UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA | IT (MODENA) | participant | 259˙511.00 |
Map
Project objective
The possibility to artificially induce and expand in vitro tissue-specific stem cells (SCs) is an important goal for regenerative medicine, to understand organ physiology, for in vitro modeling of human diseases and many other applications. Here we found that this goal can be achieved in the culture dish by transiently inducing expression of YAP or TAZ - nuclear effectors of the Hippo and biomechanical pathways - into primary/terminally differentiated cells of distinct tissue origins. Moreover, YAP/TAZ are essential endogenous factors that preserve ex-vivo naturally arising SCs of distinct tissues. In this grant, we aim to gain insights into YAP/TAZ molecular networks (upstream regulators and downstream targets) involved in somatic SC reprogramming and SC identity. Our studies will entail the identification of the genetic networks and epigenetic changes controlled by YAP/TAZ during cell de-differentiation and the re-acquisition of SC-traits in distinct cell types. We will also investigate upstream inputs establishing YAP/TAZ activity, with particular emphasis on biomechanical and cytoskeletal cues that represent overarching regulators of YAP/TAZ in tissues. For many tumors, it appears that acquisition of an immature, stem-like state is a prerequisite for tumor progression and an early step in oncogene-mediated transformation. YAP/TAZ activation is widespread in human tumors. However, a connection between YAP/TAZ and oncogene-induced cell plasticity has never been investigated. We will also pursue some intriguing preliminary results and investigate how oncogenes and chromatin remodelers may link to cell mechanics, and the plasticity of the differentiated and SC states by controlling YAP/TAZ. In sum, this research should advance our understanding of the cellular and molecular basis underpinning organ growth, tissue regeneration and tumor initiation.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Mattia Forcato, Chiara Nicoletti, Koustav Pal, Carmen Maria Livi, Francesco Ferrari, Silvio Bicciato Comparison of computational methods for Hi-C data analysis published pages: 679-685, ISSN: 1548-7091, DOI: 10.1038/nmeth.4325 |
Nature Methods 14/7 | 2019-07-05 |
| 2016 |
Francesca Zanconato, Michelangelo Cordenonsi, Stefano Piccolo YAP/TAZ at the Roots of Cancer published pages: 783-803, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2016.05.005 |
Cancer Cell 29/6 | 2019-07-05 |
| 2016 |
Craig S. Nowell, Pascal D. Odermatt, Luca Azzolin, Sylke Hohnel, Erwin F. Wagner, Georg E. Fantner, Matthias P. Lutolf, Yann Barrandon, Stefano Piccolo, Freddy Radtke Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction published pages: 168-180, ISSN: 1465-7392, DOI: 10.1038/ncb3290 |
Nature Cell Biology 18/2 | 2019-07-05 |
| 2017 |
Luca Azzolin, Stefano Piccolo A TIAM Double Hit to Oppose YAP/TAZ published pages: 607-608, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2017.04.009 |
Cancer Cell 31/5 | 2019-07-05 |
| 2016 |
F. Zanconato, S. Piccolo Eradicating tumor drug resistance at its YAP-biomechanical roots published pages: 459-461, ISSN: 0261-4189, DOI: 10.15252/embj.201593584 |
The EMBO Journal 35/5 | 2019-07-05 |
| 2017 |
Tito Panciera, Luca Azzolin, Michelangelo Cordenonsi, Stefano Piccolo Mechanobiology of YAP and TAZ in physiology and disease published pages: 758-770, ISSN: 1471-0072, DOI: 10.1038/nrm.2017.87 |
Nature Reviews Molecular Cell Biology 18/12 | 2019-07-05 |
| 2017 |
Tobias Hirsch, Tobias Rothoeft, Norbert Teig, Johann W. Bauer, Graziella Pellegrini, Laura De Rosa, Davide Scaglione, Julia Reichelt, Alfred Klausegger, Daniela Kneisz, Oriana Romano, Alessia Secone Seconetti, Roberta Contin, Elena Enzo, Irena Jurman, Sonia Carulli, Frank Jacobsen, Thomas Luecke, Marcus Lehnhardt, Meike Fischer, Maximilian Kueckelhaus, Daniela Quaglino, Michele Morgante, Silvio Bi Regeneration of the entire human epidermis using transgenic stem cells published pages: 327-332, ISSN: 0028-0836, DOI: 10.1038/nature24487 |
Nature 551/7680 | 2019-07-04 |
| 2016 |
Tito Panciera, Luca Azzolin, Atsushi Fujimura, Daniele Di Biagio, Chiara Frasson, Silvia Bresolin, Sandra Soligo, Giuseppe Basso, Silvio Bicciato, Antonio Rosato, Michelangelo Cordenonsi, Stefano Piccolo Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ published pages: 725-737, ISSN: 1934-5909, DOI: 10.1016/j.stem.2016.08.009 |
Cell Stem Cell 19/6 | 2019-07-04 |
| 2017 |
Antonio Totaro, Martina Castellan, Giusy Battilana, Francesca Zanconato, Luca Azzolin, Stefano Giulitti, Michelangelo Cordenonsi, Stefano Piccolo YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate published pages: 15206, ISSN: 2041-1723, DOI: 10.1038/ncomms15206 |
Nature Communications 8 | 2019-07-05 |
| 2018 |
Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration published pages: 35-49.e7, ISSN: 1934-5909, DOI: 10.1016/j.stem.2017.11.001 |
Cell Stem Cell 22/1 | 2019-07-04 |
| 2016 |
Francesca Zanconato, Giusy Battilana, Michelangelo Cordenonsi, Stefano Piccolo YAP/TAZ as therapeutic targets in cancer published pages: 26-33, ISSN: 1471-4892, DOI: 10.1016/j.coph.2016.05.002 |
Current Opinion in Pharmacology 29 | 2019-07-04 |
| 2015 |
Francesca Zanconato, Mattia Forcato, Giusy Battilana, Luca Azzolin, Erika Quaranta, Beatrice Bodega, Antonio Rosato, Silvio Bicciato, Michelangelo Cordenonsi, Stefano Piccolo Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth published pages: 1218-1227, ISSN: 1465-7392, DOI: 10.1038/ncb3216 |
Nature Cell Biology 17/9 | 2019-05-20 |
| 2018 |
Tito Panciera, Luca Azzolin, Daniele Di Biagio, Antonio Totaro, Michelangelo Cordenonsi, Stefano Piccolo De Novo Generation of Somatic Stem Cells by YAP/TAZ published pages: , ISSN: 1940-087X, DOI: 10.3791/57462 |
Journal of Visualized Experiments 135 | 2019-05-20 |
| 2018 |
Antonio Totaro, Martina Castellan, Daniele Di Biagio, Stefano Piccolo Crosstalk between YAP/TAZ and Notch Signaling published pages: 560-573, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2018.03.001 |
Trends in Cell Biology 28/7 | 2019-05-20 |
| 2017 |
Giovanni Sorrentino, Naomi Ruggeri, Alessandro Zannini, Eleonora Ingallina, Rebecca Bertolio, Carolina Marotta, Carmelo Neri, Elisa Cappuzzello, Mattia Forcato, Antonio Rosato, Miguel Mano, Silvio Bicciato, Giannino Del Sal Glucocorticoid receptor signalling activates YAP in breast cancer published pages: 14073, ISSN: 2041-1723, DOI: 10.1038/ncomms14073 |
Nature Communications 8 | 2019-05-20 |
| 2018 |
Francesca Zanconato, Giusy Battilana, Mattia Forcato, Letizia Filippi, Luca Azzolin, Andrea Manfrin, Erika Quaranta, Daniele Di Biagio, Gianluca Sigismondo, Vincenza Guzzardo, Pascale Lejeune, Bernard Haendler, Jeroen Krijgsveld, Matteo Fassan, Silvio Bicciato, Michelangelo Cordenonsi, Stefano Piccolo Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4 published pages: 1599-1610, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0158-8 |
Nature Medicine 24/10 | 2019-05-20 |
| 2018 |
Antonio Totaro, Tito Panciera, Stefano Piccolo YAP/TAZ upstream signals and downstream responses published pages: 888-899, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0142-z |
Nature Cell Biology 20/8 | 2019-05-20 |
| 2018 |
Jimmy Caroli, Giovanni Sorrentino, Mattia Forcato, Giannino Del Sal, Silvio Bicciato GDA, a web-based tool for Genomics and Drugs integrated analysis published pages: W148-W156, ISSN: 0305-1048, DOI: 10.1093/nar/gky434 |
Nucleic Acids Research 46/W1 | 2019-05-20 |
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