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GLYCOVAX SIGNED

A training network for the rational design of the next generation of well-defined glycoconjugate vaccines

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

GLYCOVAX project word cloud

Explore the words cloud of the GLYCOVAX project. It provides you a very rough idea of what is the project "GLYCOVAX" about.

glycoconjugate proteins young biophysics tackle action chemistry contemporarily expertise gives skills linkage rationally beneficiaries sme therapies unspecific translating mechanism sugars interaction create safer students academy screening select glycan memory giving route groups vaccinology renders protein children innovative environment combining structure site vaccination industrial relationship carrier throughput medical vaccines unmet ideas prepared structural bioconjugation intricate combination leaders carbohydrates bench multidisciplinary industry acquire synthesis academic education attachment conjugation cell preventive involve optimal scientists aid 14 linked visions medicinal network heterogeneous carbohydrate organization advancements manufacturing generation profound understand covalent conjugates transferable sugar immunology immunogenicity selective antigen glycovax glycobiology mixtures evoke

Project "GLYCOVAX" data sheet

The following table provides information about the project.

Coordinator	GLAXOSMITHKLINE VACCINES SRL Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.glycovax.eu
Total cost	3˙554˙499 €
EC max contribution	3˙554˙499 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-11-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	GLAXOSMITHKLINE VACCINES SRL GLAXOSMITHKLINE VACCINES SRL Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	coordinator	516˙122.00
2	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	716˙837.00
3	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	510˙748.00
4	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	280˙879.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
6	GLYCOUNIVERSE GMBH & CO. KOMMANDITGESELLSCHAFT AUF AKTIEN GLYCOUNIVERSE GMBH & CO. KOMMANDITGESELLSCHAFT AUF AKTIEN Organization address address: AM MUHLENBERG 11 city: POTSDAM postcode: 14476 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (POTSDAM)	participant	249˙216.00
7	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	249˙216.00
8	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS Organization address address: PARQUE TECNOLOGICO EDIFICIO 801 A city: DERIO VIZCAYA postcode: 48160 website: www.cicbiogune.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (DERIO VIZCAYA)	participant	247˙872.00
9	SVEUCILISTE U RIJECI, MEDICINSKI FAKULTET SVEUCILISTE U RIJECI, MEDICINSKI FAKULTET Organization address address: BRACE BRANCHETTA 20 city: RIJEKA postcode: 51000 website: www.medri.uniri.hr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HR (RIJEKA)	participant	247˙761.00
10	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	238˙356.00
11	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	34˙613.00
12	ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Organization address address: VIA FIORENTINA 151 city: SIENA postcode: 53100 website: www.altaweb.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	partner	0.00

Map

Project objective

GLYCOVAX is a network for the education of promising young scientists who will learn how to rationally design a next generation of well-defined and innovative glycoconjugate vaccines to improve current preventive therapies and to tackle unmet medical needs. Glycoconjugate vaccines represent the key for success of vaccination in children. The covalent linkage to proteins renders carbohydrates able to evoke a T-cell memory response. Current vaccines are prepared from heterogeneous mixtures of sugars linked by unspecific methods to the carrier protein giving complex mixtures of products. Due to this intricate structure, it has not been possible to apply a medicinal chemistry approach in the development of glycoconjugate vaccines and to fully understand their mechanism of action. Combination of novel approaches for glycan synthesis and site-selective conjugation methods now gives access to conjugates defined in sugar component and attachment site, thus leading to robust structure-immunogenicity relationship. Advancements in structural biophysics can be applied to select the optimal glycan antigen. By combining the beneficiaries’ expertise in carbohydrate synthesis, bioconjugation, high throughput screening, structural glycobiology, vaccinology and immunology, together with the experience in project management, GLYCOVAX will create a multidisciplinary environment where 14 young researchers will contribute to develop a novel route towards improved, safer and better characterized glycoconjugate vaccines, and contemporarily acquire transferable skills which will lead them to become the new leaders of academic or industrial research. The network will involve 9 academic groups and 2 industrial partners as Beneficiaries, and one SME as Partner Organization. The profound interaction between academy and industry will aid the students to get new concepts and visions for translating their ideas from the bench to the manufacturing of the next generation of glycoconjugate vaccines.

Deliverables

List of deliverables.
Local Training	Documents, reports	2020-03-06 16:14:26
Glycoscience workshops	Documents, reports	2020-02-12 17:16:50
Annual GLYCOVAX symposiums	Documents, reports	2020-02-07 15:50:47
CTS	Documents, reports	2020-02-07 15:50:47
Plan for using and disseminating knowledge	Websites, patent fillings, videos etc.	2020-02-07 15:50:48
PhD	Documents, reports	2020-02-07 15:50:44
Reports on public engagement activities	Documents, reports	2020-02-07 15:50:49
Call publication	Other	2019-09-06 08:53:52
Website	Websites, patent fillings, videos etc.	2019-09-06 08:53:53

Take a look to the deliverables list in detail: detailed list of GLYCOVAX deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Roberto Adamo, Davide Oldrini, Linda del Bino, Ana Arda, Filippo Carboni, Pedro Henriques, Francesca Angiolini, Jon I. Quintana, Ilaria Calloni, Maria R. Romano, Francesco Berti, Jesus Jimenez Barbero, Immaculada Margarit Structureâ€guided design of a Group B Streptococcus type III synthetic glycanâ€conjugate vaccine published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.202000284	Chemistry â€“ A European Journal	2020-03-10
2018	Cinzia Colombo, Olimpia Pitirollo, Luigi Lay Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development published pages: 1712, ISSN: 1420-3049, DOI: 10.3390/molecules23071712	Molecules 23/7	2020-01-30
2019	F Romero-Saavedra, D Laverde, E Kalfopoulou, C Martini, R Torelli, D Martinez-Matamoros, M Sanguinetti, J Huebner Conjugation of Different Immunogenic Enterococcal Vaccine Target Antigens Leads to Extended Strain Coverage published pages: 1589-1598, ISSN: 0022-1899, DOI: 10.1093/infdis/jiz357	The Journal of Infectious Diseases 220/10	2019-11-07
2019	Ermioni Kalfopoulou, Diana Laverde, Karmela Miklic, Felipe Romero-Saavedra, Suzana Malic, Filippo Carboni, Roberto Adamo, Tihana Lenac Rovis, Stipan Jonjic, Johannes Huebner Development of Opsonic Mouse Monoclonal Antibodies against Multidrug-Resistant Enterococci published pages: , ISSN: 0019-9567, DOI: 10.1128/iai.00276-19	Infection and Immunity 87/9	2019-11-07
2018	Tetiana Dumych, Nao Yamakawa, Adeline Sivignon, Estelle Garenaux, Stefania Robakiewicz, Bernadette Coddeville, Antonino Bongiovanni, Fabrice Bray, Nicolas Barnich, Sabine Szunerits, Christian Slomianny, Martin Herrmann, SÃ©bastien G. Gouin, Alexander D. Lutsyk, Luis E. Munoz, Frank Lafont, Christian Rolando, Rostyslav Bilyy, Julie M. J. Bouckaert Oligomannose-Rich Membranes of Dying Intestinal Epithelial Cells Promote Host Colonization by Adherent-Invasive E. coli published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.00742	Frontiers in Microbiology 9	2019-11-07
2019	Francesca Micoli, Linda Del Bino, Renzo Alfini, Filippo Carboni, Maria Rosaria Romano, Roberto Adamo Glycoconjugate vaccines: current approaches towards faster vaccine design published pages: 881-895, ISSN: 1476-0584, DOI: 10.1080/14760584.2019.1657012	Expert Review of Vaccines 18/9	2019-11-07
2018	Claudia Kohout, Cristina Santi, Laura Polito Anisotropic Gold Nanoparticles in Biomedical Applications published pages: 3385, ISSN: 1422-0067, DOI: 10.3390/ijms19113385	International Journal of Molecular Sciences 19/11	2019-11-07
2018	Daan vanâ€…derâ€…Es, Francesca Berni, Wouter F. J. Hogendorf, Nico Meeuwenoord, Diana Laverde, Angela vanâ€…Diepen, Herman S. Overkleeft, Dmitri V. Filippov, Cornelis H. Hokke, Johannes Huebner, Gijsbert A. vanâ€…derâ€…Marel, Jeroen D. C. CodÃ©e Streamlined Synthesis and Evaluation of Teichoic Acid Fragments published pages: 4014-4018, ISSN: 0947-6539, DOI: 10.1002/chem.201800153	Chemistry - A European Journal 24/16	2019-09-06
2018	Ilaria Calloni, Luca Unione, Gonzalo JimÃ©nez-OsÃ©s, Francisco Corzana, Linda Del Bino, Alessio Corrado, Olimpia Pitirollo, Cinzia Colombo, Luigi Lay, Roberto Adamo, JesÃºs JimÃ©nez-Barbero The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and Its Carba-Mimetic published pages: 4548-4555, ISSN: 1434-193X, DOI: 10.1002/ejoc.201801003	European Journal of Organic Chemistry 2018/33	2019-09-06
2018	Francesco Berti, Roberto Adamo Antimicrobial glycoconjugate vaccines: an overview of classic and modern approaches for protein modification published pages: , ISSN: 0306-0012, DOI: 10.1039/c8cs00495a	Chemical Society Reviews	2019-09-06

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