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REPROGRAM SIGNED

Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

REPROGRAM project word cloud

Explore the words cloud of the REPROGRAM project. It provides you a very rough idea of what is the project "REPROGRAM" about.

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Project "REPROGRAM" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://reprogram-horizon2020.eu
Total cost	6˙000˙000 €
EC max contribution	5˙250˙000 € (88%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	1˙112˙625.00
2	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	973˙500.00
3	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	925˙000.00
4	THE GENERAL HOSPITAL CORPORATION THE GENERAL HOSPITAL CORPORATION Organization address address: FRUIT STREET 55 city: BOSTON MA postcode: 2114 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BOSTON MA)	participant	600˙000.00
5	UNIVERSITA DEGLI STUDI DI MILANO UNIVERSITA DEGLI STUDI DI MILANO Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 website: www.unimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	587˙375.00
6	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	255˙000.00
7	UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA Organization address address: VICTOR BABES STREET 8 city: Cluj-Napoca postcode: 400012 website: www.umfcluj.ro contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RO (Cluj-Napoca)	participant	232˙500.00
8	INSTITUT DE RECHERCHES INTERNATIONALES SERVIER INSTITUT DE RECHERCHES INTERNATIONALES SERVIER Organization address address: RUE CARNOT 50 city: SURESNES postcode: 92284 website: www.servier.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SURESNES)	participant	225˙000.00
9	DESCIN BV DESCIN BV Organization address address: CONICKSMEER 2 city: Vinkeveen postcode: 3645WG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Vinkeveen)	participant	221˙500.00
10	SENSILAB POLSKA SP ZOO - SKA SENSILAB POLSKA SP ZOO - SKA Organization address address: UL GEN MARIANA LANGIEWICZA 58 city: KONSTANTYNOW LODZKI postcode: 95 050 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (KONSTANTYNOW LODZKI)	participant	117˙500.00
11	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	0.00

Map

Project objective

Up to 70% of cardiovascular events are not prevented by current therapeutic regimens. In search for additional, innovative strategies, immune cells have been recognized as key players contributing to atherosclerotic plaque progression and destabilization. Particularly the role of innate immune cells is of major interest, following the recent paradigm shift that innate immunity, considered to be incapable of learning ability, does exhibit a memory feature transduced via epigenetic modulation. Compelling evidence shows that atherosclerotic factors promote immune cell migration by pre-activation of innate immune cells. In this project called REPROGRAM, we aim to prove that innate immune cell activation via epigenetic reprogramming perpetuates the upheld systemic inflammatory state in cardiovascular disease which is common in other chronic inflammatory diseases. This opens a new therapeutic area in which epigenetic modulation of innate immune cells effectively decreases systemic inflammation impacting on chronic inflammation as well as the development of co-morbidities. The integrated use of in vitro, ex vivo and in vivo studies, including cells, mice and patients, allows translation from in vitro mechanisms to diseases (molecule-to-man) and extrapolation to cohorts (man-to-mass), enabling us to demonstrate relevance and therapeutic potential of targeting trained immunity in cardiovascular and chronic inflammatory diseases. Enforced by the promising data in oncology, the future prospects for epigenetic interventions in cardiovascular and chronic inflammatory diseases are eminent, attested by the large residual cardiovascular disease burden and the huge societal impact of other chronic inflammatory diseases. The REPROGRAM consortium consisting of key opinion leaders in the field of cardiovascular (systems) biology, immunology, epigenetic therapies and rheumatoid arthritis, with a large intersectoral network, guarantees rapid translation of early mechanistic discoveries

Deliverables

List of deliverables.
PET/CT studies in patients with active and remissive RA	Documents, reports	2020-03-24 11:01:45
24 ldlr-/- experiments using either placebo or epigenetic modulator	Documents, reports	2020-03-24 11:01:29
Nanoparticle vs. unpackaged epigenetic modulator in vitro and experimental model	Documents, reports	2020-03-24 11:00:59
Ex vivo analysis of monocyte phenotype/function/epigenome in patients with active vs. remissive RA	Documents, reports	2020-03-24 11:01:24
Gender-specific analysis addressing distinct patterns in inflammatory activity	Documents, reports	2020-03-24 11:01:39
Data on phenotype, function and epigenome of myeloid cells	Documents, reports	2020-03-24 11:01:42
Local delivery strategy development for a epigenetic modulator	Documents, reports	2020-03-24 11:01:42
Knowledge exploitation final report	Documents, reports	2020-03-24 11:01:38
Dissemination final report	Documents, reports	2020-03-24 11:01:40
Roadmap for exploitation	Documents, reports	2020-02-24 13:41:47
CID-associated DAMPs on human monocyte phenotype/function/epigenome	Documents, reports	2020-02-24 13:41:47
In vitro tests of atherogenic factors on phenotype/function/epigenetics of human myeloid cells	Documents, reports	2020-02-24 13:41:47
Relation between gene-score and cardiovascular risk	Documents, reports	2020-02-24 13:41:47
50 BMT experiments in various mouse models	Documents, reports	2020-02-24 13:41:47
Epigenetic modulators on in vitro cell systems	Documents, reports	2020-02-24 13:41:47
Young researcher training program	Documents, reports	2020-02-24 13:41:44
Validated gene score for modified epigenetic modulation	Documents, reports	2020-02-24 13:41:44
Quality Assurance File	Documents, reports	2020-02-24 13:41:44
Data management plan	Documents, reports	2020-02-24 13:41:44

Take a look to the deliverables list in detail: detailed list of REPROGRAM deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Renate M. Hoogeveen, Tjerk S.J. Opstal, Yannick Kaiser, Lotte C.A. Stiekema, Jeffrey Kroon, Remco J.J. Knol, Willem A. Bax, Hein J. Verberne, Jan H. Cornel, Erik S.G. Stroes PCSK9 Antibody Alirocumab Attenuates Arterial Wall Inflammation Without Changes inÂ Circulating Inflammatory Markers published pages: 2571-2573, ISSN: 1936-878X, DOI: 10.1016/j.jcmg.2019.06.022	JACC: Cardiovascular Imaging 12/12	2020-03-06
2018	Lotte C A Stiekema, Erik S G Stroes, Simone L Verweij, Helina Kassahun, Lisa Chen, Scott M Wasserman, Marc S Sabatine, Venkatesh Mani, Zahi A Fayad Persistent arterial wall inflammation in patients with elevated lipoprotein(a) despite strong low-density lipoprotein cholesterol reduction by proprotein convertase subtilisin/kexin type 9 antibody treatment published pages: 2775-2781, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy862	European Heart Journal 40/33	2020-02-27
2019	Esther Lutgens, Dorothee Atzler, Yvonne DÃ¶ring, Johan Duchene, Sabine Steffens, Christian Weber Immunotherapy for cardiovascular disease published pages: 3937-3946, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehz283	European Heart Journal 40/48	2020-02-24
2018	Manuela Casula, Elena Olmastroni, Angela Pirillo, Alberico Luigi Catapano, Marcello Arca, Maurizio Averna, Stefano Bertolini, Sebastiano Calandra, Alberico Luigi Catapano, Patrizia Tarugi, Fabio Pellegatta, Francesco Angelico, Marcello Arca, Maurizio Averna, Andrea Bartuli, Giacomo Biasucci, Gianni Biolo, Luca Bonanni, Katia Bonomo, Claudio Borghi, Antonio Carlo Bossi, Adriana Branchi, Francesca C Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study published pages: 413-418, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2018.08.013	Atherosclerosis 277	2020-02-24
2019	Menno P.J. de Winther, Esther Lutgens The Link between Hematopoiesis and Atherosclerosis published pages: 1869-1871, ISSN: 0028-4793, DOI: 10.1056/nejmcibr1901397	New England Journal of Medicine 380/19	2020-02-24
2019	Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure published pages: 141-144, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2018.12.076	International Journal of Cardiology 279	2020-02-24
2018	Angela Pirillo, Fabrizia Bonacina, Giuseppe Danilo Norata, Alberico Luigi Catapano The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis published pages: , ISSN: 1523-3804, DOI: 10.1007/s11883-018-0715-0	Current Atherosclerosis Reports 20/3	2020-02-24
2018	Frederick J. Raal, G. Kees Hovingh, Alberico L. Catapano Familial hypercholesterolemia treatments: Guidelines and new therapies published pages: 483-492, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2018.06.859	Atherosclerosis 277	2020-02-24
2018	Simone L. Verweij, Lotte C. A. Stiekema, Ronak Delewi, Kang H. Zheng, Sophie J. Bernelot Moens, Jeffrey Kroon, Charlotte I. Stroes, Miranda Versloot, Jan J. Piek, Hein J. Verberne, Erik S. G. Stroes Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with 18F-DPA-714 PET/CT published pages: 1956-1963, ISSN: 1619-7070, DOI: 10.1007/s00259-018-4038-8	European Journal of Nuclear Medicine and Molecular Imaging 45/11	2020-02-24
2018	JosÃ© TuÃ±Ã³n, Lina BadimÃ³n, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Imo E Hoefer, Daniel F J Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, CÃ©cile Vindis, Christian Weber, Magnus BÃ¤ck Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology published pages: 10-19, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy293	Cardiovascular Research 115/1	2020-02-24
2018	Charlotte D C C van der Heijden, Jaap Deinum, Leo A B Joosten, Mihai G Netea, Niels P Riksen The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis published pages: 944-953, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy092	Cardiovascular Research 114/7	2020-02-24
2018	I. C. L. van den Munckhof, A. Kurilshikov, R. ter Horst, N. P. Riksen, L. A. B. Joosten, A. Zhernakova, J. Fu, S. T. Keating, M. G. Netea, J. de Graaf, J. H. W. Rutten Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies published pages: 1719-1734, ISSN: 1467-7881, DOI: 10.1111/obr.12750	Obesity Reviews 19/12	2020-02-24
2018	Niels P. Riksen, Mihai G. Netea Be aware, innate immune cells remember published pages: 2218-2219, ISSN: 1945-4589, DOI: 10.18632/aging.101552	Aging 10/9	2020-02-24
2019	Siroon Bekkering, Lotte C.A. Stiekema, Sophie Bernelot Moens, Simone L. Verweij, Boris Novakovic, Koen Prange, Miranda Versloot, Jeanine E. Roeters van Lennep, Henk Stunnenberg, Menno de Winther, Erik S.G. Stroes, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia published pages: 1-2, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.05.014	Cell Metabolism 30/1	2020-02-24
2019	J. Plat, S. Baumgartner, T. Vanmierlo, D. LÃ¼tjohann, K.L. Calkins, D.G. Burrin, G. Guthrie, C. Thijs, A.A. Te Velde, A.C.E. Vreugdenhil, R. Sverdlov, J. Garssen, K. Wouters, E.A. Trautwein, T.G. Wolfs, C. van Gorp, M.T. Mulder, N.P. Riksen, A.K. Groen, R.P. Mensink Plant-based sterols and stanols in health & disease: â€œConsequences of human development in a plant-based environment?â€ published pages: 87-102, ISSN: 0163-7827, DOI: 10.1016/j.plipres.2019.02.003	Progress in Lipid Research 74	2020-02-24
2019	Charlotte D C C van der Heijden, Samuel T Keating, Laszlo Groh, Leo A B Joosten, Mihai G Netea, Niels P Riksen Aldosterone induces trained immunity: the role of fatty acid synthesis published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvz137	Cardiovascular Research	2020-02-24
2018	Laszlo Groh, Mihai G Netea, Niels P Riksen, Samuel T Keating Getting to the marrow of trained immunity published pages: 1151-1154, ISSN: 1750-1911, DOI: 10.2217/epi-2018-0098	Epigenomics 10/9	2020-02-24
2019	Julia van Tuijl, Leo A B Joosten, Mihai G Netea, Siroon Bekkering, Niels P Riksen Immunometabolism orchestrates training of innate immunity in atherosclerosis published pages: 1416-1424, ISSN: 0008-6363, DOI: 10.1093/cvr/cvz107	Cardiovascular Research 115/9	2020-02-24
2018	Niels P. Riksen, Rinke Stienstra Metabolism of innate immune cells published pages: 359-367, ISSN: 0957-9672, DOI: 10.1097/mol.0000000000000539	Current Opinion in Lipidology 29/5	2020-02-24
2019	Niels P. Riksen Trained immunity and atherosclerotic cardiovascular disease published pages: 395-400, ISSN: 0957-9672, DOI: 10.1097/mol.0000000000000628	Current Opinion in Lipidology 30/5	2020-02-24
2019	Michel Neidhart, Agnieszka Pajak, Katerina Laskari, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Esther Lutgens, Eric S. G. Stroes, Adrian Ciurea, Oliver Distler, Mariam Grigorian, Emmanuel Karouzakis Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00791	Frontiers in Immunology 10	2020-02-24
2019	Fangfang Sun, Irene Abreu-Rodriguez, Shuang Ye, Steffen Gay, Oliver Distler, Michel Neidhart, Emmanuel Karouzakis TET1 is an important transcriptional activator of TNFÎ± expression in macrophages published pages: e0218551, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0218551	PLOS ONE 14/6	2020-02-24
2018	Siroon Bekkering, Rob J.W. Arts, Boris Novakovic, Ioannis Kourtzelis, Charlotte D.C.C. van der Heijden, Yang Li, Calin D. Popa, Rob ter Horst, Julia van Tuijl, Romana T. Netea-Maier, Frank L. van de Veerdonk, Triantafyllos Chavakis, Leo A.B. Joosten, Jos W.M. van der Meer, Henk Stunnenberg, Niels P. Riksen, Mihai G. Netea Metabolic Induction of Trained Immunity through the Mevalonate Pathway published pages: 135-146.e9, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.11.025	Cell 172/1-2	2020-02-24
2017	Charlotte D.C.C. van der Heijden, Marlies P. Noz, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen, Samuel T. Keating Epigenetics and Trained Immunity published pages: , ISSN: 1523-0864, DOI: 10.1089/ars.2017.7310	Antioxidants & Redox Signaling	2020-02-24
2017	Johan G. Schnitzler, Sophie J. Bernelot Moens, Feiko Tiessens, Guido J. Bakker, Geesje M. Dallinga-Thie, Albert K. Groen, Max Nieuwdorp, Erik S. G. Stroes, Jeffrey Kroon Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy published pages: 2210-2219, ISSN: 0022-2275, DOI: 10.1194/jlr.D073197	Journal of Lipid Research 58/11	2020-02-24
2017	Sophie J. Bernelot Moens, Annette E. Neele, Jeffrey Kroon, Fleur M. van der Valk, Jan Van den Bossche, Marten A. Hoeksema, Renate M. Hoogeveen, Johan G. Schnitzler, Marie T. Baccara-Dinet, Garen Manvelian, Menno P.J. de Winther, Erik S.G. Stroes PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia published pages: 1584-1593, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx002	European Heart Journal 38/20	2020-02-24
2018	Anette Christ, Patrick GÃ¼nther, Mario A.R. Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J. Scholz, Marije Oosting, Kristian Haendler, Kevin BaÃŸler, Kathrin Klee, Jonas Schulte-Schrepping, Thomas Ulas, Simone J.C.F.M. Moorlag, Vinod Kumar, Min Hi Park, Leo A.B. Joosten, Laszlo A. Groh, Niels P. Riksen, Terje Espevik, Andreas Schlitzer, Yang Li, Michael L. Fitzgerald, Mihai G. Net Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming published pages: 162-175.e14, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.12.013	Cell 172/1-2	2020-02-24
2018	Jenneke Leentjens, Siroon Bekkering, Leo A Joosten, Mihai G Netea, David P Burgner, Niels P Riksen Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis published pages: CIRCRESAHA.117.3, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.312465	Circulation Research 2018 Jan 24	2020-02-24
2018	Laszlo Groh, Samuel T. Keating, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen Monocyte and macrophage immunometabolism in atherosclerosis published pages: 203-214, ISSN: 1863-2297, DOI: 10.1007/s00281-017-0656-7	Seminars in Immunopathology 40/2	2020-02-24
2017	Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens Exploring immune checkpoints as potential therapeutic targets in atherosclerosis published pages: 368-377, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx248	Cardiovascular Research 114/3	2020-02-24
2018	Samuel T. Keating, Janna A. van Diepen, Niels P. Riksen, Assam El-Osta Epigenetics in diabetic nephropathy, immunity and metabolism published pages: 6-20, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4490-1	Diabetologia 61/1	2020-02-24
2017	Simone L Verweij, RaphaÃ«l Duivenvoorden, Lotte C A Stiekema, Nick S Nurmohamed, Fleur M van der Valk, Miranda Versloot, Hein J Verberne, Erik S G Stroes, Matthias Nahrendorf, Siroon Bekkering, Sophie J Bernelot Moens CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease published pages: 468-475, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx224	Cardiovascular Research 114/3	2020-02-24
2017	Sophie J. Bernelot Moens, Simone L. Verweij, Johan G. Schnitzler, Lotte C.A. Stiekema, Merijn Bos, Anne Langsted, Carlijn Kuijk, Siroon Bekkering, Carlijn Voermans, Hein J. Verberne, BÃ¸rge G. Nordestgaard, Erik S.G. Stroes, Jeffrey Kroon Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in HumansHighlights published pages: 969-975, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.116.308834	Arteriosclerosis, Thrombosis, and Vascular Biology 37/5	2020-02-24
2018	Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram SlÃ¼tter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van â€˜t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis published pages: 527-542, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2017.11.055	Journal of the American College of Cardiology 71/5	2020-02-24
2017	Lotte C.A. Stiekema, Johan G. Schnitzler, Matthias Nahrendorf, Erik S.G. Stroes The maturation of a â€˜neuralâ€“hematopoieticâ€™ inflammatory axis in cardiovascular disease published pages: 507-512, ISSN: 0957-9672, DOI: 10.1097/MOL.0000000000000457	Current Opinion in Lipidology 28/6	2020-02-24
2017	Renate M Hoogeveen, Matthias Nahrendorf, Niels P Riksen, Mihai G Netea, Menno P J de Winther, Esther Lutgens, BÃ¸rge G Nordestgaard, Michel Neidhart, Erik S G Stroes, Alberico L Catapano, Siroon Bekkering Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases published pages: , ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx581	European Heart Journal	2020-02-24
2018	Vanessa Frodermann, Matthias Nahrendorf Macrophages and Cardiovascular Health published pages: 2523-2569, ISSN: 0031-9333, DOI: 10.1152/physrev.00068.2017	Physiological Reviews 98/4	2020-02-24
2018	Katrien Vandoorne, David Rohde, Hye-Yeong Kim, Gabriel Courties, Gregory Wojtkiewicz, Lisa Honold, Friedrich Felix Hoyer, Vanessa Frodermann, Ribhu Nayar, Fanny Herisson, Yookyung Jung, Pauline A. DÃ©sogÃ¨re, Claudio Vinegoni, Peter Caravan, Ralph Weissleder, David E. Sosnovik, Charles P. Lin, Filip K. Swirski, Matthias Nahrendorf Imaging the Vascular Bone Marrow Niche During Inflammatory Stress published pages: 415-427, ISSN: 0009-7330, DOI: 10.1161/circresaha.118.313302	Circulation Research 123/4	2020-02-24
2018	Ellen Rouwet, Esther Lutgens 2016 Jeffrey M. Hoeg Award Lecture published pages: 1678-1688, ISSN: 1079-5642, DOI: 10.1161/atvbaha.118.307742	Arteriosclerosis, Thrombosis, and Vascular Biology 38/8	2020-02-24
2018	Matthias Nahrendorf Myeloid cell contributions to cardiovascular health and disease published pages: 711-720, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0064-0	Nature Medicine 24/6	2020-02-24
2018	Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens CD40L Deficiency Protects Against Aneurysm Formation published pages: 1076-1085, ISSN: 1079-5642, DOI: 10.1161/atvbaha.117.310640	Arteriosclerosis, Thrombosis, and Vascular Biology 38/5	2020-02-24
2017	Alberico Catapano, Angela Pirillo, Giuseppe Danilo Norata Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives published pages: 343-351, ISSN: 1178-2048, DOI: 10.2147/VHRM.S130338	Vascular Health and Risk Management Volume 13	2020-02-24
2018	Fabrizia Bonacina, David Coe, Guosu Wang, Maria P. Longhi, Andrea Baragetti, Annalisa Moregola, Katia Garlaschelli, Patrizia Uboldi, Fabio Pellegatta, Liliana Grigore, Lorenzo Da Dalt, Andrea Annoni, Silvia Gregori, Qingzhong Xiao, Donatella Caruso, Nico Mitro, Alberico L. Catapano, Federica M. Marelli-Berg, Giuseppe D. Norata Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05322-1	Nature Communications 9/1	2020-02-24
2018	Andrea Caporali, Magnus BÃ¤ck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, JosÃ© TuÃ±Ã³n, Cecile Vindis, Jolanda J Wentzel, Seppo YlÃ¤-Herttuala, Paul C Evans Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology published pages: 1411-1421, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy184	Cardiovascular Research 114/11	2020-02-24
2018	Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction published pages: e0202150, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0202150	PLOS ONE 13/8	2020-02-24
2018	Annette E. Neele, Marion J.J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C.S. Boshuizen, Koen H.M. Prange, Hung-Jen Chen, Jan Van den Bossche, Cindy P.P.A. van Roomen, Annelie Shami, Johannes H.M. Levels, Jeffrey Kroon, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Menno P.J. de Winther Myeloid Kdm6b deficiency results in advanced atherosclerosis published pages: 156-165, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2018.05.052	Atherosclerosis 275	2020-02-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REPROGRAM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "REPROGRAM" are provided by the European Opendata Portal: CORDIS opendata.