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ComplexSex SIGNED

Sex-limited experimental evolution of natural and novel sex chromosomes: the role of sex in shaping complex traits

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ComplexSex project word cloud

Explore the words cloud of the ComplexSex project. It provides you a very rough idea of what is the project "ComplexSex" about.

serve mimicking expression theory flatworm creation drive antagonism maps trait fitness individual evolution introgression data divergence origin shape antagonistic distantly females usually genotype made experimental genetic sex hermaphroditic linked genome sexually sexed evolutionary variation positive primarily nature drosophila opposite biology hermaphrodites simulation coevolution contributions sexual reciprocal reflects confirm analytical suggest limited phenotype refute loci populations population additive hypotheses correlation previously had reproduction contribution interacting separate quantitative macrostomum chromosomes chromosome assumption intersexual empirical males modeling species architecture patterns differences combination unsolved understand progress traits thought

Project "ComplexSex" data sheet

The following table provides information about the project.

Coordinator	LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	https://www.biology.lu.se/jessica-abbott
Total cost	1˙492˙011 €
EC max contribution	1˙492˙011 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	coordinator	1˙492˙011.00

Map

Project objective

The origin and evolution of sexual reproduction and sex differences represents one of the major unsolved problems in evolutionary biology, and although much progress had been made both via theory and empirical research, recent data suggest that sex chromosome evolution may be more complex than previously thought. The concept of sexual antagonism (when there is a positive intersexual genetic correlation in trait expression but opposite fitness effects of the trait(s) in males and females) has become essential to our understanding of sex chromosome evolution. The goal of this proposal is to understand how the interacting effects of sexual antagonism, sex-linked genetic variation, and sex-specific selection shape the genetic architecture of complex traits. I will test the hypotheses that: 1) individual sexually antagonistic loci are common in the genome, both in separate-sexed species and in hermaphrodites, and drive patterns of sexual antagonism often seen on the trait level. 2) That the response to sex-specific selection in sex-linked loci is usually due to standing sexually antagonistic genetic variation. 3) That sexually antagonistic variation is primarily non-additive in nature. To accomplish this, I will use a combination of approaches, including sex-limited experimental evolution of the X chromosome and reciprocal sex chromosome introgression among distantly related populations of Drosophila, quantitative genetic analysis and experimental evolution mimicking the creation of a novel sex chromosome in the hermaphroditic flatworm Macrostomum, and analytical and simulation modeling. This project will serve to confirm or refute the assumption that trait-level sexual antagonism reflects the contributions of many individual sexually antagonistic loci, increase our understanding of the contribution of coevolution of the sex chromosomes to population divergence, and help provide us with a better general understanding of how genotype maps to phenotype.

Publications

List of publications.
year	authors and title	journal	last update
2018	Colin Olito, Jessica K. Abbott, Crispin Y. Jordan The interaction between sex-specific selection and local adaptation in species without separate sexes published pages: 20170426, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0426	Philosophical Transactions of the Royal Society B: Biological Sciences 373/1757	2019-04-02
2017	Anna K. NordÃ©n Sex Chromosome Evolution in a Hermaphrodite: Genetic and phenotypic relationships between sex roles published pages: , ISSN: , DOI:		2019-04-02
2018	Abbott, Jessica; MagalhÃ£es, Sara; Rodrigues, Leonor; Alpedrinha, Joao Will Love Tear Them Apart? Identifying the Eco-Evolutionary Feedbacks of Sexual Traits published pages: , ISSN: , DOI: 10.20944/PREPRINTS201808.0508.V1	2	2019-04-02
2018	Suvi Ponnikas, Hanna Sigeman, Jessica K. Abbott, Bengt Hansson Why Do Sex Chromosomes Stop Recombining? published pages: 492-503, ISSN: 0168-9525, DOI: 10.1016/j.tig.2018.04.001	Trends in Genetics 34/7	2019-04-02
2017	Katrine Koch Lund-Hansen Experimental Manipulation of Sexual Antagonism in Drosophila melanogaster published pages: , ISSN: , DOI:		2019-04-02

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