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ANGIO-IMAGE

ANGIO-tracer for immuno-PET imaging: a stratification and monitoring tool for anti-angiogenesis treatment

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ANGIO-IMAGE project word cloud

Explore the words cloud of the ANGIO-IMAGE project. It provides you a very rough idea of what is the project "ANGIO-IMAGE" about.

global malignancies outcome monitor stratification receive tool sales focussing million first 78 commercial total treatment restrict optimal cancer challenged standard angiotarget expensive care reducing prostate 14 introduce cumulative introduction crc administration units healthcare colorectal tracer lung net drug ineffective gt strategies competitiveness spared strategy approved imaging successful patient undertreatment revenue responders patients aat markets accounting stage prior commercially billion acceptance cancers 2024 benefit angio breast inadequate 45 261 profit world progression angiogenic avastin resistance2 angiogenesis therapy unnecessary dependent utility 18 efficacy bevacizumab anti rates save stratify annual monitoring 700 agent

Project "ANGIO-IMAGE" data sheet

The following table provides information about the project.

Coordinator	ANGIOTARGET BV Organization address address: DE BOELELAAN 1118 AFD MED ONC city: AMSTERDAM postcode: 1081 HZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-1-2015
Funding Scheme	SME-1
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2016-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ANGIOTARGET BV ANGIOTARGET BV Organization address address: DE BOELELAAN 1118 AFD MED ONC city: AMSTERDAM postcode: 1081 HZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	50˙000.00

Map

Project objective

AngioTarget will introduce an angiogenesis imaging agent (ANGIO-tracer) to stratify patients prior to anti-angiogenic therapy (AAT). This proposal is focussing on colorectal cancer (CRC) and will try to save 45,000 stage II/III CRC patients from undertreatment and 60,000 stage IV patients from unnecessary treatment in Europe each year. CRC is one of the most common cancers world-wide. AAT is a widely used and promising approach to restrict growth and progression of all angiogenesis-dependent malignancies. However, this expensive anti-cancer strategy is challenged by low response rates, inadequate efficacy and resistance2. Currently, there is no tool available to stratify patients prior to AAT or monitor response to therapy. The first approved and commercially most successful anti-angiogenic drug is Avastin (Bevacizumab), accounting for over €7 billion in annual sales. As a first phase towards global acceptance of ANGIO-tracer as a standard for stratification and monitoring in AAT of cancer, AngioTarget will focus on the utility of ANGIO-tracer in determining and monitoring Avastin treatment strategies in CRC. This will ensure that all CRC patients receive optimal care and responders can benefit from AAT while non-responders are spared from ineffective treatment.

Commercial introduction in Europe of ANGIO-tracer as a stratification tool in CRC will: - Improve patient outcome by enabling optimal treatment of over 18,700 stage II/III and 14,000 stage IV patients within 5 years, reducing healthcare costs related to ineffective Avastin administration with €1.8 billion in 2024 - Increase growth and competitiveness of AngioTarget, including cumulative sales of over 261,000 units (total revenue €78 million) within 5 years and a cumulative net profit of >€30 million - Open up new markets for ANGIO-tracer (e.g. lung, prostate, breast cancer)

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The information about "ANGIO-IMAGE" are provided by the European Opendata Portal: CORDIS opendata.