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ESA -ITN SIGNED

European Sepsis Academy: towards new biomarkers to improve sepsis management

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ESA -ITN project word cloud

Explore the words cloud of the ESA -ITN project. It provides you a very rough idea of what is the project "ESA -ITN" about.

mba firms leverage chain interlinked professional representing trial biomarkers institutes stage potency molecular proposition industry school discovery infrastructures train global covers reflects mini special company intersection companies sepsis business interdisciplinary building incorporating designed model shared setup collaborations itn place full countries clinical secondments innovation antiinflammatory specialist medical complementary rapid practical transferable interactions break world networks platforms diagnostics network skills esa diagnostic links orientated entire cover pathogenesis training private incorporates economics biomarker beneficiary genetic 15 esr esrs innovative international tested intersectorial variety cellular bioinformatics

Project "ESA -ITN" data sheet

The following table provides information about the project.

Coordinator	AMC MEDICAL RESEARCH BV Organization address address: MEIBERGDREEF 9 city: AMSTERDAM ZUIDOOST postcode: 1105AZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://europeansepsisacademy.com/
Total cost	3˙895˙551 €
EC max contribution	3˙895˙551 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AMC MEDICAL RESEARCH BV AMC MEDICAL RESEARCH BV Organization address address: MEIBERGDREEF 9 city: AMSTERDAM ZUIDOOST postcode: 1105AZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM ZUIDOOST)	coordinator	766˙122.00
2	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	546˙575.00
3	CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Organization address address: RUE DU BUGNON 21 city: LAUSANNE postcode: 1011 website: www.chuv.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	530˙453.00
4	BIOMERIEUX SA BIOMERIEUX SA Organization address address: Chemin de l'Orme city: Marcy l'Etoile postcode: 69280 website: www.biomerieux.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Marcy l'Etoile)	participant	525˙751.00
5	INSTITUT EUROPEEN D ADMINISTRATION DES AFFAIRES INSTITUT EUROPEEN D ADMINISTRATION DES AFFAIRES Organization address address: BOULEVARD DE CONSTANCE 903F city: FONTAINEBLEAU CEDEX postcode: 77305 website: http://www.insead.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (FONTAINEBLEAU CEDEX)	participant	525˙751.00
6	HUMANITAS MIRASOLE SPA HUMANITAS MIRASOLE SPA Organization address address: VIA MANZONI 56 city: ROZZANO (MI) postcode: 20100 website: www.humanitas.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROZZANO (MI))	participant	516˙122.00
7	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	484˙773.00
8	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	0.00

Map

Project objective

ESA-ITN will break through the state of the art in sepsis diagnostics and will train 15 early-stage researchers (ESRs) to determine the clinical potency of a variety of new complementary sepsis biomarkers. These cover the full range of the antiinflammatory response in sepsis, at genetic, molecular and cellular level. Rapid and practical biomarker diagnostics for sepsis will be developed by building on some of the world's most innovative diagnostic platforms. In addition, a whole new clinical research model that incorporates use of biomarker diagnostics will be designed and tested.

All 15 interlinked ESR projects have an interdisciplinary component (intersection of sepsis research, product development, economics and medical practice) and international (representing 10 countries) and industry collaborations (incorporating 3 diagnostics firms, 1 bioinformatics company and a business school). Interactions within the network are strengthened by meaningful secondments, which take place at private beneficiary or partner institutes.

The training programme covers: 1. Specialist training in an international, interdisciplinary and intersectorial sepsis-orientated research project; 2. Advanced technology training in pathogenesis, biomarker discovery, diagnostics, trial design and innovation management; 3. Professional training in transferable skills, including the special ESA-ITN mini-MBA.

The setup of ESA-ITN is unique as it reflects the entire innovation value chain for sepsis biomarker diagnostics. ESA-ITN is composed of leading institutes in sepsis research and a selection of Europe's top biomarker diagnostics companies. Links to various global networks and shared research infrastructures in the field of sepsis further leverage the proposition of ESA-ITN.

Deliverables

List of deliverables.
Validation of the primers and setup the Fluidigm technology for analysing MDSC	Documents, reports	2020-02-25 17:07:51
First online version of network public multi modality website	Websites, patent fillings, videos etc.	2020-02-25 17:07:50
Technology set up for the of DNA methylation probes of isolated cell fractions which can be used as prognostic markers in sepsis patients	Documents, reports	2020-02-25 17:07:51
Validation of DNA methylation probes of isolated cell fractions	Documents, reports	2020-02-25 17:07:51
Validation of the array used for whole blood leukocyte DNA analyses	Documents, reports	2020-02-25 17:07:50
Report of studies with PTX3, TIR8 and IRAK-M targeted mice in murine models of sepsis	Documents, reports	2020-02-25 17:07:51
Signed PCDPs	Documents, reports	2020-02-25 17:07:52
Further caracterisation of MDSC subpopulations	Documents, reports	2020-02-25 17:07:51

Take a look to the deliverables list in detail: detailed list of ESA -ITN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Aspasia Liassidou, Georgios Renieris, Dionysiaâ€Irene Droggiti, Theologia Gkavogianni, Christakis Liassides, Labros Sabracos, Evangelos J. Giamarellosâ€Bourboulis, Charalampos S. Siristatidis Association of modulation of proâ€inflammatory responses by dectinâ€2 with preterm delivery: An experimental model published pages: , ISSN: 1046-7408, DOI: 10.1111/aji.13216	American Journal of Reproductive Immunology 83/3	2020-04-01
2019	Amira A Bhalodi, Tjitske S R van Engelen, Harjeet S Virk, W Joost Wiersinga Impact of antimicrobial therapy on the gut microbiome published pages: i6-i15, ISSN: 0305-7453, DOI: 10.1093/jac/dky530	Journal of Antimicrobial Chemotherapy 74/Supplement_1	2020-04-01
2019	Eleonora Ciarlo, Tytti Heinonen, Charlotte ThÃ©roude, Fatemeh Asgari, Didier Le Roy, Mihai G Netea, Thierry Roger Trained immunity confers broad-spectrum protection against bacterial infections published pages: , ISSN: 0022-1899, DOI: 10.1093/infdis/jiz692	The Journal of Infectious Diseases	2020-02-25
2018	W. Joost Wiersinga, Harjeet S. Virk, Alfredo G. Torres, Bart J. Currie, Sharon J. Peacock, David A. B. Dance, Direk Limmathurotsakul Melioidosis published pages: 17107, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.107	Nature Reviews Disease Primers 4	2020-02-25
2018	Nora Suzanne Wolff, Floor Hugenholtz, Willem Joost Wiersinga The emerging role of the microbiota in the ICU published pages: , ISSN: 1364-8535, DOI: 10.1186/s13054-018-1999-8	Critical Care 22/1	2020-02-25
2017	Eleonora Ciarlo, Tytti Heinonen, Charlotte ThÃ©roude, Jacobus Herderschee, Matteo Mombelli, JÃ©rÃ´me Lugrin, Marc PfefferlÃ©, Beatrice Tyrrell, Sarah Lensch, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01037	Frontiers in Immunology 8	2020-02-25
2019	Eleni Karakike, Evangelos J. Giamarellos-Bourboulis Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00055	Frontiers in Immunology 10	2020-02-25
2019	Irene T. Schrijver, Charlotte ThÃ©roude, Thierry Roger Myeloid-Derived Suppressor Cells in Sepsis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00327	Frontiers in Immunology 10	2020-02-25
2018	ChloÃ© Albert-Vega, Dina M. Tawfik, Sophie Trouillet-Assant, Laurence Vachot, FranÃ§ois Mallet, Julien Textoris Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine published pages: 1-9, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02367	Frontiers in Immunology 9	2020-02-25
2019	Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M. Koutelidakis, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Iraklis Tsangaris Late Peaks of HMGB1 and Sepsis Outcome published pages: 1, ISSN: 1073-2322, DOI: 10.1097/shk.0000000000001265	SHOCK	2020-02-25
2018	Tytti Heinonen, Eleonora Ciarlo, Charlotte ThÃ©roude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy, Thierry Roger Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02675	Frontiers in Immunology 9	2020-02-25

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