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INTERPLAY SIGNED

Interplay between genetic determinants of glycaemia, type 2 diabetes and cardiovascular disease in interaction with dietary and lifestyle factors

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INTERPLAY project word cloud

Explore the words cloud of the INTERPLAY project. It provides you a very rough idea of what is the project "INTERPLAY" about.

functional variations difficult international magic dietary precision genetic dpp influence lifestyle proportion hyperglycaemia missing glycaemia avenues systematic cardiogram heart risk diagram epic conduct replicate determinants medicine diabetes strategies insights progression effect gwas coding interact gene intermediate phenotypes extend disease independent clinical genome intervention differential era launch genetics association metabolic prevention explained predimed small validate heritability emerged uncover skills structural valuable capability traits variants t2d hypothesis emerge successful implicated group biological populations vulnerable faster individuals englobes coronary interaction associations interplay regions trial researcher deploy genetically chd networks components

Project "INTERPLAY" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) Organization address address: CARRER ESCORXADOR city: TARRAGONA postcode: 43003 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://scholar.harvard.edu/jmerino/home
Total cost	257˙191 €
EC max contribution	257˙191 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-GF
Starting year	2017
Duration (year-month-day)	from 2017-02-18 to 2020-02-17

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) Organization address address: CARRER ESCORXADOR city: TARRAGONA postcode: 43003 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TARRAGONA)	coordinator	257˙191.00
2	THE GENERAL HOSPITAL CORPORATION THE GENERAL HOSPITAL CORPORATION Organization address address: FRUIT STREET 55 city: BOSTON MA postcode: 2114 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BOSTON MA)	partner	0.00

Map

Project objective

Genome-wide association studies (GWAS) for complex traits, including glycaemia, type 2 diabetes (T2D) and coronary heart disease (CHD) have been successful in identifying genetic variants associated with those phenotypes. However, they explained only a small proportion of the estimated heritability. Possible reasons include the interplay between genetics and lifestyle determinants, small-effect variants, structural variations and the difficult to characterize non-coding functional variants that interact with other genetic regions. This proposal, in a new era of precision medicine, englobes the systematic study of the interplay between genetic variants associated with glycaemia, T2D, CHD and dietary and lifestyle factors. We propose to conduct a comprehensive analysis of gene and gene-lifestyle interaction, including the existing international GWAS consortia of CARDIoGRAM, DIAGRAM, MAGIC, the U.S. based DPP clinical trial, and the European-wide networks of EPIC-InterAct and PREDIMED. We will test hypothesis about: 1) whether genetically driven hyperglycaemia increases risk of CHD, 2) the association between genetic determinants of CHD and intermediate metabolic phenotypes, and 3) whether dietary components and lifestyle changes influence these associations. Finally, we will extend and replicate these previous results in two independent populations, and to deploy a new method to identify implicated biological pathways. Information that will emerge from that project will provide valuable insights into missing heritability for T2D and CHD. Specifically we expect to uncover genetic determinants for faster CHD progression in T2D, identifying vulnerable individuals who are more likely to experience a differential response to current prevention strategies and to validate potential targets and avenues for intervention. The experienced researcher will emerged from the project with new skills, and the capability to launch his own research group in Europe.

Publications

List of publications.
year	authors and title	journal	last update
2018	Merino J, Florez JC Precision medicine in diabetes: an opportunity for clinical translation. published pages: , ISSN: 1749-6632, DOI:	Annals of the New York Academy of Science	2019-06-06
2018	Franks PW, Merino J Gene-lifestyle interplay in type 2 diabetes. published pages: , ISSN: 0959-437X, DOI:	Current Opinion in Genetics & Development	2019-06-06
2017	Jordi Merino, Aaron Leong, Daniel C. Posner, Bianca Porneala, LluÃs Masana, JosÃ©e Dupuis, Jose C. Florez Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes published pages: 687-693, ISSN: 0149-5992, DOI: 10.2337/dc16-2625	Diabetes Care 40/5	2019-06-13

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The information about "INTERPLAY" are provided by the European Opendata Portal: CORDIS opendata.