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CONSALT SIGNED

CONtrast through metal-enriched polymer SALTs: novel contrast agents for dual-energy micro-computed tomography

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CONSALT project word cloud

Explore the words cloud of the CONSALT project. It provides you a very rough idea of what is the project "CONSALT" about.

simultaneous successfully scanners computed selective ct staining visualization cellular soft mitochondria destructive visualize few agents diagnosis screening morphology fast imaging sub separate functional dual microscopic limitations entire tomography science single least micro cells overcoming cytoplasm investigations overcome tissue micrometer materials consalt pathological evaluation tumors enhancement material biopsies energy contrast small microct resolution biological biocompatible certain structures histology stains optimized incorporation ray samples limited 2d missing volume slices pathologies iodine selectivity conventional cytoskeleton biopsy bismuth nucleus complement combination x 3d medicinal classify

Project "CONSALT" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.e17.ph.tum.de
Total cost	171˙460 €
EC max contribution	171˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-RI
Starting year	2016
Duration (year-month-day)	from 2016-04-01 to 2018-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	171˙460.00

Map

Project objective

X-ray micro computed tomography (microCT) is currently successfully used in material science investigations as well as in non-destructive testing enabling 3D imaging of these materials with micrometer resolution. The application of microCT for biological samples (e.g. biopsies) is limited by the missing contrast of soft tissue, which is important to visualize microscopic cellular structures. CONSALT aims at overcoming these limitations by simultaneous and yet separate visualization of a combination of at least two elements. Furthermore, it aims to advance x-ray microCT by allowing the visualization of single cells, which is currently not possible with the state-of-the-art x-ray microCT devices. The development and medicinal application of a fast X-ray based 3D-screening system for tissue biopsies to identify, visualize, and classify different pathologies, will complement conventional histology, which is based on the evaluation of a few selective 2D slices of a 3D biopsy, and further improve diagnosis (e.g. visualization of small tumors within the entire tissue volume or other 3D morphology parameters). Novel specific and functional contrast agents (stains) are essential to achieve the 3D visualization of specific pathological cellular or sub-cellular structures (e.g. nucleus or cytoskeleton). The design, development and testing of such new contrast agents to overcome the challenges of contrast enhancement and selectivity for certain tissue and cellular structures (e.g. nucleus, mitochondria or cytoplasm), which is seen through conventional staining in histology, is proposed here. The CT-contrast will be achieved by incorporation of biocompatible elements with a high z-component such as iodine and bismuth. The specific CT-contrast will be further optimized through dual-energy X-ray microCT-scanners allowing for visualization of at least two elements.

Publications

List of publications.
year	authors and title	journal	last update
2017	Madleen Busse and Franz Pfeiffer Novel heavy metal ion-hematein-complexes useful as ex vivo contrast agent for a computed tomography scanning of a biological sample, ex vivo method for investigating a biological sample, and use of the complexes (EP-Patent application 19 196 491.9) published pages: , ISSN: , DOI:		2019-06-13
2017	Madleen Busse and Franz Pfeiffer Novel heavy metal ion-ligand-complexes useful as ex vivo contrast agent for a computed tomography scanning of a biological sample, ex vivo method for investigating a biological sample, and use of the complexes (EP-Patent application: 19 196 492.7) published pages: , ISSN: , DOI:		2019-06-13
2018	Madleen Busse, Mark MÃ¼ller, Melanie A. Kimm, Simone Ferstl, Sebastian Allner, Klaus Achterhold, Julia Herzen, Franz Pfeiffer Three-dimensional virtual histology enabled through cytoplasm-specific X-ray stain for microscopic and nanoscopic computed tomography published pages: 2293-2298, ISSN: 0027-8424, DOI: 10.1073/pnas.1720862115	Proceedings of the National Academy of Sciences 115/10	2019-06-13

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