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PMTFOS SIGNED

Plant metallothioneins as potential players in food security

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PMTFOS project word cloud

Explore the words cloud of the PMTFOS project. It provides you a very rough idea of what is the project "PMTFOS" about.

accumulation plant iead shows parts translation human mts cadmium predicted crops disciplinary animal underlying excellence scientific female drought micronutrient metallothioneins staple scientist protein 500 million food plants planta unusual resistance crop context molecular heat biophysics global cereals diets grains spanning tolerance socioeconomical meets yields overcome strategies promise zinc outcomes outstanding agriculture events discrimination family humans mt science central issue stress tremendous micronutrients biofortification deficiency unprecedented toxic preferences fundamental cross cereal homeostasis furnish bioavailability physiological elucidated people sorghum health public security complement empowering inspiring threatened prevalent questions edible dietary frequent insights

Project "PMTFOS" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House city: COVENTRY postcode: CV4 8UW website: www.warwick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-08-01 to 2019-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF WARWICK THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House city: COVENTRY postcode: CV4 8UW website: www.warwick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (COVENTRY)	coordinator	195˙454.00

Map

Project objective

Food security is a socioeconomical concept that involves access to food that meets people's dietary needs and preferences. Current and future food security is threatened by more frequent and more widespread drought events, leading to reduction in crop yields. A related issue of global importance is micronutrient deficiency. Zinc, a micronutrient involved in all major physiological processes, has outstanding potential to improve crop yields, as well as animal and human health. One long-term and cost-effective approach to overcome zinc deficiency in humans involves biofortification - increasing micronutrients in staple crops. In this context, the molecular processes underlying (a) drought resistance, and (b) micronutrients accumulation in edible parts of crop plants need to be elucidated. One protein family – the plant metallothioneins (MTs) – shows tremendous promise in enhancing drought tolerance, zinc accumulation, and bioavailability. This project aims to analyse the complement of MTs from sorghum, a cereal plant with unusual drought- and heat-resistance that is a staple crop for 500 Million people. Sorghum is predicted to become more prevalent in future European diets. In this project, the questions whether and which MT may be involved in (a) zinc accumulation in grains, (b) discrimination between essential zinc and toxic cadmium, and (c) drought stress tolerance, will be addressed. A unique cross-disciplinary approach spanning in-planta analysis to protein biophysics will furnish unprecedented insight into crucial aspects of plant zinc homeostasis and drought tolerance. Outcomes will impact European scientific excellence by empowering a female scientist from Central Europe, and by inspiring further work in plant science. Future translation of the fundamental insights generated will Iead to applications in agriculture (e.g. novel biofortification strategies for cereals), and enhance the European public’s awareness of the importance of zinc for human health.

Publications

List of publications.
year	authors and title	journal	last update
2018	Agnieszka Mierek-Adamska, GraÅ¼yna B. DÄ…browska, Claudia A. Blindauer The type 4 metallothionein from Brassica napus seeds folds in a metal-dependent fashion and favours zinc over other metals published pages: 1430-1443, ISSN: 1756-5901, DOI: 10.1039/c8mt00161h	Metallomics 10/10	2019-10-01

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The information about "PMTFOS" are provided by the European Opendata Portal: CORDIS opendata.