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CD4DNASP SIGNED

Cell intrinsic control of CD4 T cell differentiation by cytosolic DNA sensing pathways

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CD4DNASP project word cloud

Explore the words cloud of the CD4DNASP project. It provides you a very rough idea of what is the project "CD4DNASP" about.

combining acid trigger deoxyribonucleic differentiation tlr9 molecular cd4 pathogens deficient autologous triggered gene binding microbial altered relationship activation events vitro ultimately shown sensors sensing pathogen cells origin tlr biophysical transcriptional adaptive dependent gap decipher mice series dna event transgenic signaling independent patterns shaping unravel detection defense cytosolic cell cellular infectious expression myeloid sensor suggests vivo innate structure documented host immune cytoplasmic toll relies immunomodulators perceive contribution performed receptor fill

Project "CD4DNASP" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-08-01 to 2021-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙500˙000.00

Map

Project objective

This proposal aims to investigate the role of cytosolic DNA sensing pathways in CD4 T cell differentiation. Cellular host defense to pathogens relies on the detection of pathogen-associated molecular patterns including deoxyribonucleic acid (DNA), which can be recognized by host myeloid cells through Toll-like receptor (TLR) 9 binding. Recent evidence however suggests that innate immune cells can also perceive cytoplasmic DNA from infectious or autologous origin through cytosolic DNA sensors triggering TLR9-independent signaling. Activation of cytosolic DNA sensor-dependent signaling pathways has been clearly shown to trigger innate immune responses to microbial and host DNA, but the contribution of cytosolic DNA sensors to the differentiation of CD4 T cells, an essential event for shaping adaptive immune responses, has not been documented. This proposal aims to fill this current knowledge gap. We aim to decipher the molecular series of transcriptional events triggered by DNA in CD4 T cells that ultimately result in altered T cell differentiation. This aim will be addressed by combining in vitro and in vivo approaches such as advanced gene expression analysis of CD4 T cells and use of transgenic and gene-deficient mice. Structure activity relationship and biophysical studies will also be performed to unravel novel immunomodulators able to affect CD4 T cell differentiation.

Publications

List of publications.
year	authors and title	journal	last update
2019	Thaiz Rivera Vargas, Lionel Apetoh Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors? published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01181	Frontiers in Immunology 10	2019-10-03
2017	Thaiz Rivera Vargas, Zhijian Cai, Yingying Shen, Magalie Dosset, Isis Benoit-Lizon, Tiffany Martin, AurÃ©lie Roussey, Richard A. Flavell, FranÃ§ois Ghiringhelli, Lionel Apetoh Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00468-w	Nature Communications 8/1	2019-07-08
2017	Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser Signalling strength determines proapoptotic functions of STING published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00573-w	Nature Communications 8/1	2019-07-08
2017	Thaiz Rivera Vargas, Etienne Humblin, FrÃ©dÃ©rique VÃ©gran, FranÃ§ois Ghiringhelli, Lionel Apetoh TH9 cells in anti-tumor immunity published pages: 39-46, ISSN: 1863-2297, DOI: 10.1007/s00281-016-0599-4	Seminars in Immunopathology 39/1	2019-07-08
2017	Carole Fournier, Thaiz Rivera Vargas, Tiffany Martin, AndrÃ©a Melis, Lionel Apetoh Immunotherapeutic properties of chemotherapy published pages: 83-88, ISSN: 1471-4892, DOI: 10.1016/j.coph.2017.05.003	Current Opinion in Pharmacology 35	2019-05-22
2019	Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, AndrÃ©a Melis, Tiffany Martin, Xia Lin, Heng Yang, Qingqing Li, Jinfeng Chen, SylvÃ¨re Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bongers, Veronique Minard-Colin, Eric Tartour, Laurence Zitvogel, Lionel Apetoh, Yuting Ma, Mikael J. Pittet, Oliver Kepp, Guido Kroemer Crizotinib-induced immunogenic cell death in non-small cell lung cancer published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09415-3	Nature Communications 10/1	2019-05-22
2017	Thaiz Rivera Vargas, Lionel Apetoh Danger signals: Chemotherapy enhancers? published pages: 175-193, ISSN: 0105-2896, DOI: 10.1111/imr.12581	Immunological Reviews 280/1	2019-05-22
2017	Thaiz Rivera Vargas, FranÃ§ois Martin, Lionel Apetoh Role of interleukin-1-family cytokines on effector CD4 T cell differentiation published pages: 24, ISSN: 2219-2824, DOI: 10.5411/wji.v7.i2.24	World Journal of Immunology 7/2	2019-05-22
2017	Thaiz Rivera Vargas, Isis Benoit-Lizon, Lionel Apetoh Rationale for stimulator of interferon genesâ€“targeted cancer immunotherapy published pages: 86-97, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2016.12.028	European Journal of Cancer 75	2019-04-14
2018	Elise Jacquin, Lionel Apetoh Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01023	Frontiers in Immunology 9	2019-04-14
2018	Magalie Dosset, Thaiz Rivera Vargas, AnaÃ¯s Lagrange, Romain Boidot, FrÃ©dÃ©rique VÃ©gran, AurÃ©lie Roussey, Fanny Chalmin, Lucile Dondaine, Catherine Paul, Elodie Lauret Marie-Joseph, FranÃ§ois Martin, Bernhard Ryffel, Christophe Borg, Olivier AdotÃ©vi, FranÃ§ois Ghiringhelli, Lionel Apetoh PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer published pages: e1433981, ISSN: 2162-402X, DOI: 10.1080/2162402X.2018.1433981	OncoImmunology 7/6	2019-04-14

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