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BBDiag SIGNED

Blood Biomarker-based Diagnostic Tools for Early Stage Alzheimer’s Disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BBDiag project word cloud

Explore the words cloud of the BBDiag project. It provides you a very rough idea of what is the project "BBDiag" about.

responds 13 blood tools transferable biomarkers personal societal patients clinical alzheimer met bbdiag trained efforts expertise entrepreneurial care interdisciplinary point framework gaining imposed disease identification cutting triple technological generation technologies stage industrial thinking sensitive ad minimally notable lack business detection modifying industry vitae synergies etn combined skilled techniques treatments academic uses training preventive brings creative trials platform failures fellows diagnostics figure medical first invasive discovery strategies scientific provision successful people careers multidisciplinary innovatively intensive despite skills quality intervention researcher nature setting edge million trial academia biosensing innovative mind experts underlines drug double establishes

Project "BBDiag" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF PLYMOUTH Organization address address: DRAKE CIRCUS city: PLYMOUTH postcode: PL4 8AA website: www.plymouth.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://bbdiag-itn-etn.eu/
Total cost	3˙465˙708 €
EC max contribution	3˙465˙708 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF PLYMOUTH UNIVERSITY OF PLYMOUTH Organization address address: DRAKE CIRCUS city: PLYMOUTH postcode: PL4 8AA website: www.plymouth.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (PLYMOUTH)	coordinator	819˙863.00
2	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Organization address address: Piazzale Aldo Moro 5 city: ROMA postcode: 185 website: www.uniroma1.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	516˙122.00
3	ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Organization address address: VIA MARIO NEGRI 2 city: MILANO postcode: 20156 website: www.marionegri.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	424˙439.00
4	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	290˙081.00
5	NORDIC BIOSCIENCE A/S NORDIC BIOSCIENCE A/S Organization address address: HERLEV HOVEDGADE 205-207 city: HERLEV postcode: 2730 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HERLEV)	participant	290˙081.00
6	PROGNOMICS LTD PROGNOMICS LTD Organization address address: BROOMFIELD & ALEXANDER LTD CHARTER COURT PHOENIX WAY ENTERPRISE PARK city: SWANSEA postcode: SA7 9FS website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWANSEA)	participant	273˙287.00
7	SWANSEA UNIVERSITY SWANSEA UNIVERSITY Organization address address: SINGLETON PARK city: SWANSEA postcode: SA2 8PP website: www.swan.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWANSEA)	participant	273˙287.00
8	UNIVERSITATSMEDIZIN ROSTOCK UNIVERSITATSMEDIZIN ROSTOCK Organization address address: SCHILLINGALLEE 35 city: ROSTOCK postcode: 18055 website: www.med.uni-rostock.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ROSTOCK)	participant	249˙216.00
9	CENTRO DE INVESTIGACION BIOMEDICA EN RED ENFERMEDADES NEURODEGENERATIVAS CENTRO DE INVESTIGACION BIOMEDICA EN RED ENFERMEDADES NEURODEGENERATIVAS Organization address address: "Hospital Universitario ""Virgen del Rocio"" - Edif. de Laboratorios, 2a planta - Avda. Manual Siurot S/N" city: SEVILLA postcode: 41013 website: www.ciberned.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SEVILLA)	participant	247˙872.00
10	ADVANCED MEDICAL PROJECTS SOCIEDAD LIMITADA ADVANCED MEDICAL PROJECTS SOCIEDAD LIMITADA Organization address address: AVDA CHILOECHES NUM 73 city: GUADALAJARA postcode: 19160 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (GUADALAJARA)	participant	81˙453.00
11	NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S Organization address address: Herlev Hovedgade 207 city: Helev postcode: 2730 website: www.nordicbioscience.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (Helev)	participant	0.00
12	China Capital Medical University China Capital Medical University Organization address address: Xi tou tiao, You an men Wai 10 city: Beijing postcode: 100069 website: http://www.ccmu.edu.cn contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CN (Beijing)	partner	0.00
13	ENGAGE - KEY TECHNOLOGY VENTURES AG ENGAGE - KEY TECHNOLOGY VENTURES AG Organization address address: Bahnhofstrasse 54 city: KARLSRUHE postcode: 76137 website: www.engage-ventures.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KARLSRUHE)	partner	0.00
14	HUNAN UNIVERSITY HUNAN UNIVERSITY Organization address address: LUSHAN SOUTH ROAD 1 city: CHANGSHA postcode: 410082 website: http://www.hnu.cn contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CN (CHANGSHA)	partner	0.00
15	Re:Cognition Health Ltd. Re:Cognition Health Ltd. Organization address address: 45 Queen Anne Street city: London postcode: W1G 9JF website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (London)	partner	0.00

Map

Project objective

Alzheimer’s disease (AD) affects more than 7 million people in Europe and this figure is expected to double every 20 years. Despite intensive efforts, no disease-modifying treatments or preventive strategies are available. The lack of specific, sensitive and minimally invasive diagnostics to identify people with early-stage AD to be included in clinical drug intervention trials is among the main reasons for many notable trial failures. The main challenges in developing the required diagnostics are identification of AD biomarkers and development of their detection techniques. The complex and interdisciplinary nature of the research underlines the need for innovative training of a new generation of researchers in the field. BBDiag responds to such a need and establishes a much-needed ETN for blood based early-AD diagnostics to address these challenges. It brings together leading academic and industrial experts from five major consortia in Europe and uses their synergies to build a triple-i research & training platform with the required multidisciplinary expertise and cutting-edge technologies. BBDiag Fellows will be trained under the Vitae Researcher Development Framework innovatively combined with the BBDiag platform for gaining interdisciplinary scientific and transferable skills as well as personal quality, creative thinking and business mind-set. The ETN has a highly innovative research programme for the discovery of AD biomarkers, development of novel biosensing techniques and point of care tools, and for technological exploitation of the diagnostics. These advances will strongly support improved care provision and development of disease-modifying treatments and preventive strategies for AD patients. More importantly, BBDiag will deliver its first generation of 13 highly-skilled, creative and entrepreneurial Fellows, setting them on a path to successful careers in academia or industry to ensure that the medical and societal challenges imposed by AD are met.

Deliverables

List of deliverables.
Dissemination report	Documents, reports	2019-09-18 10:55:32
Supervisory Board of the network	Other	2019-09-18 10:55:31
Report on network training events & secondments	Documents, reports	2019-09-18 10:55:31
Progress Report	Documents, reports	2019-09-18 10:55:31

Take a look to the deliverables list in detail: detailed list of BBDiag deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Stefan Teipel, Alexandra KÃ¶nig, Jesse Hoey, Jeff Kaye, Frank KrÃ¼ger, Julie M. Robillard, Thomas Kirste, Claudio Babiloni Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia published pages: 1216-1231, ISSN: 1552-5260, DOI: 10.1016/j.jalz.2018.05.003	Alzheimer\'s & Dementia 14/9	2019-09-18
2019	Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco FamÃ , Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Lucia Fraioli, Lucilla Parnetti, Lucia Farotti, Michela Pievani, Fabrizia D\'Antonio, Carlo De Lena, Bahar GÃ¼ntekin, Lutfu HanoÄŸlu, GÃ¶rsev Yener, Derya Durusu Emek-SavaÅŸ, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Giovanni B. Frisoni, Maria Francesca De Pandis Levodopa may affect cortical excitability in Parkinson\'s disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms published pages: 9-20, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.08.010	Neurobiology of Aging 73	2019-09-18
2018	Moira Marizzoni, Clarissa Ferrari, Jorge Jovicich, Diego Albani, Claudio Babiloni, Libera Cavaliere, Mira Didic, Gianluigi Forloni, Samantha Galluzzi, Karl-Titus Hoffmann, JosÃ© Luis Molinuevo, Flavio Nobili, Lucilla Parnetti, Pierre Payoux, Federica Ribaldi, Paolo Maria Rossini, Peter SchÃ¶nknecht, Andrea Soricelli, Tilman Hensch, Magda Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C. Richardson, RÃ©gis Bordet, Olivier Blin, Giovanni B. Frisoni Predicting and Tracking Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimerâ€™s Disease: Structural Brain Biomarkers published pages: 1-12, ISSN: 1387-2877, DOI: 10.3233/jad-180152	Journal of Alzheimer\'s Disease	2019-09-18
2018	Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco FamÃ , Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Fabrizia D\'Antonio, Carlo De Lena, Bahar GÃ¼ntekin, Lutfu HanoÄŸlu, Erol BaÅŸar, GÃ¶rsev Yener, Derya Durusu Emek-SavaÅŸ, Antonio Ivano Triggiani, John Paul Taylor, Maria Francesca De Pandis, Laura Vacca, Giovanni B. Frisoni, Fabrizio Stocchi Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimerâ€™s and Parkinsonâ€™s diseases published pages: 766-782, ISSN: 1388-2457, DOI: 10.1016/j.clinph.2018.01.009	Clinical Neurophysiology 129/4	2019-09-18
2018	Diego Albani, Moira Marizzoni, Clarissa Ferrari, Federica Fusco, Lucia Boeri, Ilaria Raimondi, Jorge Jovicich, Claudio Babiloni, Andrea Soricelli, Roberta Lizio, Samantha Galluzzi, Libera Cavaliere, Mira Didic, Peter SchÃ¶nknecht, JosÃ© Luis Molinuevo, Flavio Nobili, Lucilla Parnetti, Pierre Payoux, Luisella Bocchio, Marco Salvatore, Paolo Maria Rossini, Magda Tsolaki, Pieter Jelle Visser, Jill C. Richardson, Jens Wiltfang, RÃ©gis Bordet, Olivier Blin, Gianluigi Forloni, Giovanni B. Frisoni, PharmaCog Consortium Plasma AÎ²42 as Biomarker of Prodromal Alzheimerâ€™s Disease Progression in Patients with Amnestic Mild Cognitive Impairment: Evidence from the PharmaCog/E-ADNI Study published pages: 1-12, ISSN: 1387-2877, DOI: 10.3233/jad-180321	Journal of Alzheimer\'s Disease	2019-09-18
2018	Xinzhong Li, Haiyan Wang, Jintao Long, Genhua Pan, Taigang He, Oleg Anichtchik, Robert Belshaw, Diego Albani, Paul Edison, Elaine K Green, James Scott Systematic Analysis and Biomarker Study for Alzheimerâ€™s Disease published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-35789-3	Scientific Reports 8/1	2019-09-18
2018	Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Dario Arnaldi, Francesco FamÃ , Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B. Frisoni, Fabrizia D\'Antonio, Carlo De Lena, Bahar GÃ¼ntekin, Lutfu HanoÄŸlu, Erol BaÅŸar, GÃ¶rsev Yener, Derya Durusu Emek-SavaÅŸ, Antonio Ivano Triggiani, Raffaella Franciotti, John Paul Taylor, Laura Vacca, Maria Francesca De Pandis, Laura Bonanni Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer\'s and Lewy body diseases: an EEG study published pages: 18-40, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2017.12.023	Neurobiology of Aging 65	2019-09-18
2019	Michiel Van Bulck, Ana Sierra-Magro, Jesus Alarcon-Gil, Ana Perez-Castillo and Jose A. Morales-Garcia Novel Approaches for the Treatment of Alzheimerâ€™s and Parkinsonâ€™s Disease published pages: 1044, ISSN: 1422-0067, DOI: 10.3390/ijms20030719	International Journal of Molecular Sciences 20/5	2019-09-18
2018	Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, RenÃ© S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Maria-Teresa Ferretti, Nathalie George, Remy Genthon, Marie-Odile Habert, Karl Herholz, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, StÃ©phane LehÃ©ricy, Jean Lorenceau, Christian Neri, Robert NisticÃ², Francis Nyasse-Messene, Craig Ritchie, Simone Rossi, Emiliano Santarnecchi, Olaf Sporns, Steven R. Verdooner, Andrea Vergallo, Nicolas Villain, Erfan Younesi, Francesco Garaci, Simone Lista Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology published pages: S47-S105, ISSN: 1387-2877, DOI: 10.3233/jad-179932	Journal of Alzheimer\'s Disease 64/s1	2019-09-18
2018	Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Marie-Odile Habert, Hugo Bertin, Maxime Locatelli, Stephane LehÃ©ricy, Bruno Dubois, Stefan J. Teipel, Harald Hampel CLINICAL SIGNIFICANCE OF IN-VIVO STAGING OF REGIONAL AMYLOID DEPOSITION IN SUBJECTIVE MEMORY COMPLAINERS published pages: P1262-P1263, ISSN: 1552-5260, DOI: 10.1016/j.jalz.2018.06.1774	Alzheimer\'s & Dementia 14/7	2019-09-18
2019	Anitha Devadoss, Rhiannan Forsyth, Ryan Bigham, Hina Abbasi, Muhammad Ali, Zari Tehrani, Yufei Liu, Owen. J. Guy Ultrathin Functional Polymer Modified Graphene for Enhanced Enzymatic Electrochemical Sensing published pages: 16, ISSN: 2079-6374, DOI: 10.3390/bios9010016	Biosensors 9/1	2019-09-18
2019	Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois, Harald Hampel Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-019-0466-3	Alzheimer\'s Research & Therapy 11/1	2019-09-18
2018	Kamrul Islam, Samar Damiati, Jagriti Sethi, Ahmed Suhail, Genhua Pan Development of a Label-Free Immunosensor for Clusterin Detection as an Alzheimerâ€™s Biomarker published pages: 308, ISSN: 1424-8220, DOI: 10.3390/s18010308	Sensors 18/1	2019-09-18

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