PEROXIREDOXIN-CLOCK

A new intracellular metabolic timer mechanism to induce cell death selectively in cancer cells

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	231˙283 €
EC contributo	231˙283 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IEF
Funding Scheme	MC-IEF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-08-04   -   2016-08-03

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	coordinator	231˙283.20

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 Obiettivo del progetto (Objective)

'Peroxiredoxins (PRX) are at the heart of mechanisms gating the spatiotemporal distribution of ROS molecules within the cell and thereby deeply involved in the development or progression of disease. With the host group’s recent discovery on the circadian nature of PRX-hyperoxidation cycles, PRXs emerge to be tested for driving the physiological 24 h periodic fluctuations of the cellular redox state and ROS-signaling, both being critical in cell cycle control. The potential of the PRX-clock to robustly orchestrate cell cycle progression or apoptotic pathways will be analyzed in the proposed multidisciplinary study. The working hypothesis of the project is that this new timing mechanism operates even in rapidly proliferating cells and that it can be manipulated to deteriorate cancer cell survival selectively. Identification of new ROS-regulated targets promoting apoptosis specifically in transformed cells will have a huge impact on cancer therapy. At the host Institute in Cambridge, U.K., the Fellow will reveal post-transcriptionally regulated targets of PRX and their involvement in ROS-signaling and apoptosis induction in cancer. Through this project he will be able to address hot scientific issues and do important science in the future; furthermore, he will learn many new creative ways of thinking applied by world-renowned researchers in Cambridge. Know-how acquired during this training will open new intersectoral dimensions (Cell cycle biology, ROS biology) for the Fellow, and the evaluation of data obtained during the project will strengthen his interdisciplinary way of thinking.'