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PAIN-Net SIGNED

Molecule-to-man pain network

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PAIN-Net project word cloud

Explore the words cloud of the PAIN-Net project. It provides you a very rough idea of what is the project "PAIN-Net" about.

proteomics disease innovative 40 net epigenetics interaction 50 pathophysiology scientific functioning susceptibility signatures basic companies diseases first mouse models readily implants patients insufficient responsiveness network science sequencing pharmacogenomics stage analgesic population clinical exome scientists training social cas molecule causing cell channel consolidate sodium prepare biotechnology talented opportunity neuropathic knock translating crisp urgently screening enormous nociceptor bioreactor burden inspired encapsulated private extensive analgesia pain characterisation neurological generation relief treatments committed cancer benefits inadequate analgesics platform man originate 5 academic biophysics throughput career individual entrepreneurial 30 survivors skills

Project "PAIN-Net" data sheet

The following table provides information about the project.

Coordinator	FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA Organization address address: VIA GIOVANNI CELORIA 11 city: MILANO postcode: 20133 website: www.istituto-besta.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.pain-net.eu
Total cost	3˙335˙316 €
EC max contribution	3˙335˙316 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-02-01 to 2021-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA Organization address address: VIA GIOVANNI CELORIA 11 city: MILANO postcode: 20133 website: www.istituto-besta.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	258˙061.00
2	CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Organization address address: Rue Laurent Fries 1 city: ILLKIRCH GRAFFENSTADEN postcode: 67404 website: www.igbmc.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ILLKIRCH GRAFFENSTADEN)	participant	788˙626.00
3	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	510˙748.00
4	NEUROSCIENCE TECHNOLOGIES SLP NEUROSCIENCE TECHNOLOGIES SLP Organization address address: Baldiri Reixac 15-21 city: Barcelona postcode: 8028 website: www.nsc-tec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Barcelona)	participant	495˙745.00
5	ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Organization address address: VIA ZAMBONI 33 city: BOLOGNA postcode: 40126 website: www.unibo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	258˙061.00
6	DI.V.A.L. TOSCANA SRL DI.V.A.L. TOSCANA SRL Organization address address: VIA MADONNA DEL PIANO 6 city: SESTO FIORENTINO FI postcode: 50019 website: www.divalsrl.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SESTO FIORENTINO FI)	participant	258˙061.00
7	FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI Organization address address: Via Venezian 1 city: Milan postcode: 20133 website: www.istitutotumori.mi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Milan)	participant	258˙061.00
8	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	258˙061.00
9	YALE UNIVERSITY YALE UNIVERSITY Organization address address: WHITNEY AVENUE 155 ROOM 214 city: NEW HAVEN postcode: 06520 8337 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW HAVEN)	participant	249˙888.00
10	NSGENE AS NSGENE AS Organization address address: BALTORPVEJ 154 city: BALLERUP postcode: 2750 website: www.nsgene.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BALLERUP)	participant	0.00
11	CAREERS RESEARCH AND ADVISORY CENTRE (CRAC) LIMITED (THE) CAREERS RESEARCH AND ADVISORY CENTRE (CRAC) LIMITED (THE) Organization address address: 22 SIGNET COURT SWANN ROAD city: CAMBRIDGE postcode: CB5 8LA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	partner	0.00
12	CFc srl CFc srl Organization address address: Via Giuseppe Mussi 1 city: MILANO postcode: 20154 website: www.cf-consulting.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	partner	0.00

Map

Project objective

Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer pain patients experience insufficient analgesia. Signatures of individual susceptibility to pain and analgesic responsiveness are urgently needed to improve patients’ management. Such advances are expected to originate from integrated clinical, basic science and entrepreneurial research readily translating scientific findings into benefits for patients. To consolidate these aims, a new generation of scientists with wide knowledge in neuropathic pain, focused research skills and experience in the interaction with biotechnology companies is needed. The PAIN-Net programme, based on a highly innovative platform of training-through-research and strongly committed to such objectives, will support such talented and inspired early stage researchers. Their research projects, embedded in an advanced molecule-to-man pain network, will contribute to better understanding individual susceptibility to pain and analgesics responsiveness based on next generation sequencing, whole exome sequencing, epigenetics and pharmacogenomics studies, nociceptor and sodium channel functioning based on biophysics and proteomics studies, targeted analgesics based on high-throughput screening, targeted analgesic delivery based on encapsulated cell bioreactor implants, and to the development and extensive characterisation of the first knock-in mouse models of sodium channel-related neuropathic pain based on the CRISP-Cas technology. Most of all, the PAIN-Net programme will offer the unique opportunity to enhance scientific capabilities and prepare to high level academic or private applied research career.

Deliverables

List of deliverables.
Supervisory Board of the network	Other	2020-04-08 09:54:21
Public engagement & dissemination plan	Other	2020-04-08 09:54:21
Recruitment report	Other	2020-04-08 09:54:21

Take a look to the deliverables list in detail: detailed list of PAIN-Net deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	B. T. A. de Greef, J. G. J. Hoeijmakers, C. M. L. Gorissen-Brouwers, M. Geerts, C. G. Faber, I. S. J. Merkies Associated conditions in small fiber neuropathy - a large cohort study and review of the literature published pages: 348-355, ISSN: 1351-5101, DOI: 10.1111/ene.13508	European Journal of Neurology 25/2	2020-04-08
2019	Ivo Eijkenboom, Maurice Sopacua, Janneke G J Hoeijmakers, Bianca T A de Greef, Patrick Lindsey, Rowida Almomani, Margherita Marchi, Jo Vanoevelen, Hubertus J M Smeets, Stephen G Waxman, Giuseppe Lauria, Ingemar S J Merkies, Catharina G Faber, Monique M Gerrits Yield of peripheral sodium channels gene screening in pure small fibre neuropathy published pages: 342-352, ISSN: 0022-3050, DOI: 10.1136/jnnp-2018-319042	Journal of Neurology, Neurosurgery & Psychiatry 90/3	2020-04-08
2018	Margherita Marchi, Vincenzo Provitera, Maria Nolano, Marcello Romano, Simona Maccora, Ilaria D\'Amato, Erika Salvi, Monique Gerrits, Lucio Santoro, Giuseppe Lauria A novel SCN9A splicing mutation in a compound heterozygous girl with congenital insensitivity to pain, hyposmia and hypogeusia published pages: 202-206, ISSN: 1085-9489, DOI: 10.1111/jns.12280	Journal of the Peripheral Nervous System 23/3	2020-04-08

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The information about "PAIN-NET" are provided by the European Opendata Portal: CORDIS opendata.