Explore the words cloud of the VINCAT project. It provides you a very rough idea of what is the project "VINCAT" about.
The following table provides information about the project.
Coordinator |
UNIVERSITAT WIEN
Organization address contact info |
Coordinator Country | Austria [AT] |
Total cost | 1˙940˙025 € |
EC max contribution | 1˙940˙025 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2017 |
Duration (year-month-day) | from 2017-01-01 to 2021-12-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | UNIVERSITAT WIEN | AT (WIEN) | coordinator | 1˙940˙025.00 |
The preparation of complex molecular architectures employing multi-component reactions where the number of bond-forming events is maximised is a central goal of the discipline of Organic Synthesis. The contemporary, pressing need for sustainable chemical reactions has raised the demand for novel reaction families that explore the concept of redox-neutrality and proceed with the generation of minimal waste. In this proposal, I present a unified and conceptually novel approach to atom-economical C-C bond formation in challenging contexts without the need for transition metal promoters or reagents. To this end, I propose the innovative harvesting of the potential of vinyl cation intermediates as platforms for the deployment of nucleophilic entities capable of orchestrating rearrangement reactions. The combination of such high-energy intermediates, generated under mild conditions, with the power of carefully designed rearrangements leads to an array of useful new transformations. Furthermore, the very high atom-economy and simplicity of these reactions renders them not only sustainable and environmentally friendly but also highly appealing for large-scale applications. Additional approaches to enantioselective synthesis further enhance the methods proposed. The paradigm proposed herein for the exploitation of vinyl cations will also open up new vistas in the centuries-old aldol reaction and in amination chemistry. This showcases the vast potential of these simple principles of chemical reactivity. The myriad of new reactions and new product families made possible by VINCAT will decisively enrich the toolbox of the synthetic practitioner.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Pauline Adler, Amandine Pons, Jing Li, Jörg Heider, Bogdan R. Brutiu, Nuno Maulide Chemoselektive Aktivierung von Diethylphosphonaten: modulare Synthese von biologisch relevanten phosphonylierten Grundgerüsten published pages: 13514-13518, ISSN: 0044-8249, DOI: 10.1002/ange.201806343 |
Angewandte Chemie 130/40 | 2020-01-30 |
2017 |
Giovanni Di Mauro, Boris Maryasin, Daniel Kaiser, Saad Shaaban, Leticia González, Nuno Maulide Mechanistic Pathways in Amide Activation: Flexible Synthesis of Oxazoles and Imidazoles published pages: 3815-3818, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b01678 |
Organic Letters 19/14 | 2019-06-06 |
2018 |
Daniel H. O\' Donovan, Paul Aillard, Martin Berger, Aurélien de la Torre, Desislava Petkova, Christian Knittl-Frank, Danny Geerdink, Marcel Kaiser, Nuno Maulide C−H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity published pages: 10737-10741, ISSN: 1433-7851, DOI: 10.1002/anie.201804551 |
Angewandte Chemie International Edition 57/33 | 2019-06-06 |
2018 |
Boris Maryasin, Philipp Marquetand, Nuno Maulide Machine Learning for Organic Synthesis: Are Robots Replacing Chemists? published pages: 6978-6980, ISSN: 1433-7851, DOI: 10.1002/anie.201803562 |
Angewandte Chemie International Edition 57/24 | 2019-06-06 |
2017 |
Daniel Kaiser, Christopher J. Teskey, Pauline Adler, Nuno Maulide Chemoselective Intermolecular Cross-Enolate-Type Coupling of Amides published pages: 16040-16043, ISSN: 0002-7863, DOI: 10.1021/jacs.7b08813 |
Journal of the American Chemical Society 139/45 | 2019-06-06 |
2018 |
James D. Neuhaus, Adriano Bauer, Alexandre Pinto, Nuno Maulide A Catalytic Cross-Olefination of Diazo Compounds with Sulfoxonium Ylides published pages: 16215-16218, ISSN: 1433-7851, DOI: 10.1002/anie.201809934 |
Angewandte Chemie International Edition 57/49 | 2019-06-06 |
2018 |
Alexandre Pinto, Daniel Kaiser, Boris Maryasin, Giovanni Di Mauro, Leticia González, Nuno Maulide Hydrative Aminoxylation of Ynamides: One Reaction, Two Mechanisms published pages: 2515-2519, ISSN: 0947-6539, DOI: 10.1002/chem.201706063 |
Chemistry - A European Journal 24/10 | 2019-06-06 |
2018 |
Boris Maryasin, Dainis Kaldre, Renan Galaverna, Immo Klose, Stefan Ruider, Martina Drescher, Hanspeter Kählig, Leticia González, Marcos N. Eberlin, Igor D. Jurberg, Nuno Maulide Unusual mechanisms in Claisen rearrangements: an ionic fragmentation leading to a meta -selective rearrangement published pages: 4124-4131, ISSN: 2041-6520, DOI: 10.1039/c7sc04736c |
Chemical Science 9/17 | 2019-06-06 |
2018 |
Dainis Kaldre, Immo Klose, Nuno Maulide Stereodivergent synthesis of 1,4-dicarbonyls by traceless charge–accelerated sulfonium rearrangement published pages: 664-667, ISSN: 0036-8075, DOI: 10.1126/science.aat5883 |
Science 361/6403 | 2019-06-06 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "VINCAT" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "VINCAT" are provided by the European Opendata Portal: CORDIS opendata.
Why is the world green: testing top-down control of plant-herbivore food webs by experiments with birds, bats and ants
Read MoreHigh-throughput single-cell phenotypic analysis of functional antibody repertoires
Read MoreCross-talk between platelets and immunity - implications for host homeostasis and defense
Read More