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reLIVE SIGNED

Unraveling complex organ regeneration through live imaging and molecular profiling approaches

Total Cost €

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EC-Contrib. €

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Partnership

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 reLIVE project word cloud

Explore the words cloud of the reLIVE project. It provides you a very rough idea of what is the project "reLIVE" about.

time    combines    parhyale    extensive    cell    relive    limbs    regenerative    hawaiensis    tools    glia    tracking    advantage    organisms    behaviors    fish    unipotent    progenitors    adult    parts    contrast    course    epidermis    model    biological    shared    centuries    committed    first    poorly    questions    cutting    functional    animals    nematodes    embryonic    de    profiling    combine    animal    fundamental    live    reconstruction    development    groups    represented    periods    limited    medical    crustacean    vertebrates    classic    mediated    underpin    regenerating    neurons    spatial    mammals    emerge    answer    differentiated    stem    imaging    diverse    tendons    multipotent    lineage    evolutionary    body    injury    differ    edge    cells    arise    individual    novo    way    explores    crispr    flatworms    organ    regeneration    unanswered    marking    transcriptional    week    crustaceans    types    continuous    limb    muscle    molecular    genetic    history    flies    morphogenesis    scales    regenerate    many    undifferentiated    amputation    temporal   

Project "reLIVE" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙571˙694 €
 EC max contribution 2˙571˙694 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙571˙694.00

Map

 Project objective

Many animals have the ability to regenerate parts of their body following injury or amputation. While there is great biological and medical interest in this process, many fundamental questions remain unanswered, because complex organ regeneration is poorly represented in classic model organisms; flies, nematodes and mammals have limited regenerative abilities, in contrast to flatworms, crustaceans and fish.

reLIVE explores fundamental questions on regeneration in an emerging crustacean model, Parhyale hawaiensis, which combines extensive regenerative abilities, advanced genetic tools and live imaging.

The project will address the following fundamental, centuries-old questions on regeneration: 1) Which are the progenitors that underpin complex organ regeneration? Do epidermis, tendons, neurons, glia and muscle arise de novo from undifferentiated adult stem cells, or do they emerge from differentiated cell types? Are the progenitors unipotent/committed or multipotent? Which are their molecular responses and behaviors during the course of regeneration? 2) Do diverse animal groups regenerate in the same way? Do the regenerative progenitors of crustaceans have common molecular and functional properties with those of vertebrates and flatworms? Do they have a shared evolutionary history? 3) How does regeneration differ from development? Are these processes operating on comparable temporal and spatial scales? How similar are the transcriptional responses and cell behaviors that underpin embryonic and regenerative morphogenesis of the limb?

To answer these questions, reLIVE will take advantage of the unique opportunities offered by Parhyale limb regeneration and, for the first time, combine four cutting-edge approaches: a) CRISPR-mediated marking of specific cell types, b) continuous live imaging and cell tracking in regenerating limbs over week-long periods, c) a novel method of cell lineage reconstruction, and d) transcriptional profiling on individual cells.

 Publications

year authors and title journal last update
List of publications.
2019 M. Weigert, U. Schmidt, R. Haase, K. Sugawara, G. Myers
Star-convex Polyhedra for 3D Object Detection and Segmentation in Microscopy
published pages: , ISSN: , DOI:
arXiv arXiv:1908.03636 2019-08-29
2019 C. Sinigaglia, M. Averof
The multifaceted role of nerves in animal regeneration
published pages: , ISSN: 0959-437X, DOI:
Curr Op Genet & Dev accepted for publication 2019-08-29

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