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reLIVE SIGNED

Unraveling complex organ regeneration through live imaging and molecular profiling approaches

Total Cost €

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EC-Contrib. €

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Partnership

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 reLIVE project word cloud

Explore the words cloud of the reLIVE project. It provides you a very rough idea of what is the project "reLIVE" about.

combines    groups    course    temporal    reconstruction    progenitors    parts    cutting    regenerate    crustaceans    relive    biological    flatworms    flies    animals    molecular    differ    limb    centuries    week    shared    history    cell    individual    novo    organisms    injury    adult    vertebrates    transcriptional    emerge    classic    advantage    combine    many    parhyale    stem    development    crispr    differentiated    hawaiensis    mediated    glia    tracking    animal    limited    amputation    epidermis    represented    regenerating    multipotent    regeneration    mammals    periods    unipotent    lineage    types    tendons    genetic    muscle    morphogenesis    evolutionary    nematodes    imaging    continuous    arise    time    crustacean    fundamental    answer    unanswered    cells    poorly    organ    contrast    limbs    questions    body    medical    model    live    neurons    edge    first    embryonic    way    undifferentiated    extensive    regenerative    tools    diverse    de    profiling    marking    spatial    functional    explores    committed    scales    fish    underpin    behaviors   

Project "reLIVE" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙571˙694 €
 EC max contribution 2˙571˙694 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙571˙694.00

Map

 Project objective

Many animals have the ability to regenerate parts of their body following injury or amputation. While there is great biological and medical interest in this process, many fundamental questions remain unanswered, because complex organ regeneration is poorly represented in classic model organisms; flies, nematodes and mammals have limited regenerative abilities, in contrast to flatworms, crustaceans and fish.

reLIVE explores fundamental questions on regeneration in an emerging crustacean model, Parhyale hawaiensis, which combines extensive regenerative abilities, advanced genetic tools and live imaging.

The project will address the following fundamental, centuries-old questions on regeneration: 1) Which are the progenitors that underpin complex organ regeneration? Do epidermis, tendons, neurons, glia and muscle arise de novo from undifferentiated adult stem cells, or do they emerge from differentiated cell types? Are the progenitors unipotent/committed or multipotent? Which are their molecular responses and behaviors during the course of regeneration? 2) Do diverse animal groups regenerate in the same way? Do the regenerative progenitors of crustaceans have common molecular and functional properties with those of vertebrates and flatworms? Do they have a shared evolutionary history? 3) How does regeneration differ from development? Are these processes operating on comparable temporal and spatial scales? How similar are the transcriptional responses and cell behaviors that underpin embryonic and regenerative morphogenesis of the limb?

To answer these questions, reLIVE will take advantage of the unique opportunities offered by Parhyale limb regeneration and, for the first time, combine four cutting-edge approaches: a) CRISPR-mediated marking of specific cell types, b) continuous live imaging and cell tracking in regenerating limbs over week-long periods, c) a novel method of cell lineage reconstruction, and d) transcriptional profiling on individual cells.

 Publications

year authors and title journal last update
List of publications.
2019 M. Weigert, U. Schmidt, R. Haase, K. Sugawara, G. Myers
Star-convex Polyhedra for 3D Object Detection and Segmentation in Microscopy
published pages: , ISSN: , DOI:
arXiv arXiv:1908.03636 2019-08-29
2019 C. Sinigaglia, M. Averof
The multifaceted role of nerves in animal regeneration
published pages: , ISSN: 0959-437X, DOI:
Curr Op Genet & Dev accepted for publication 2019-08-29

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The information about "RELIVE" are provided by the European Opendata Portal: CORDIS opendata.

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