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B-SMART SIGNED

Brain-Specific, Modular and Active RNA Therapeutics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

B-SMART project word cloud

Explore the words cloud of the B-SMART project. It provides you a very rough idea of what is the project "B-SMART" about.

domain nanoparticle 130 physico vesicle billion trigger excellent substantial patients lipid burden unambiguous uniform manner antibodies extracellular local quality vitro mutually manufacture arrive shows blood compatibility platform nanobodies payload treat financial exception microfluidic cell coupled consisting socio ready carry administration active chemical responsive formulation diseases clinical coordinated polymer ensures ligand good nasal sites vhhs systemic carrier select progressive brain assembly neurodegenerative efficacy rna acceptable economic heavy injection translation time constraints nanoparticles tested achieves modular protocol exploratory clear formulations rnas therapeutic smart chain 2008

Project "B-SMART" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://b-smart-project.eu/
Total cost	5˙998˙303 €
EC max contribution	5˙998˙303 € (100%)
Programme	1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-2016-two-stage
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	861˙080.00
2	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	889˙151.00
3	VIB VZW VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	862˙812.00
4	ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI SPA ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI SPA Organization address address: VIA FOSSIGNANO 2 city: APRILIA postcode: 4011 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (APRILIA)	participant	691˙250.00
5	SINTEF AS SINTEF AS Organization address address: STRINDVEGEN 4 city: TRONDHEIM postcode: 7034 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TRONDHEIM)	participant	580˙773.00
6	MALVERN PANALYTICAL LIMITED MALVERN PANALYTICAL LIMITED Organization address address: GROVEWOOD ROAD ENIGMA BUSINESS PARK city: MALVERN postcode: WR14 1XZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MALVERN)	participant	571˙250.00
7	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	participant	551˙375.00
8	EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Organization address address: HEINRICH-HERTZ-ALLEE 1 city: ST INGBERT postcode: 66386 website: www.eurice.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ST INGBERT)	participant	503˙750.00
9	20MED THERAPEUTICS BV 20MED THERAPEUTICS BV Organization address address: DRIENERLOLAAN 5 KAMER ZH252 city: ENSCHEDE postcode: 7522 NB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	participant	398˙125.00
10	STIFTELSEN SINTEF STIFTELSEN SINTEF Organization address address: STRINDVEIEN 4 city: TRONDHEIM postcode: 7034 website: www.sintef.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TRONDHEIM)	participant	88˙736.00

Map

Project objective

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases.

I. To design modular nanoparticles consisting of o an active RNA payload o established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular vesicle-based) nanoparticles o a targeting ligand consisting of the variable domain of heavy chain only antibodies (also known as VHHs or nanobodies), which are coupled to the carrier platform

II. To manufacture the modular nanoparticles using a microfluidic assembly system that will ensure quality-by-design: uniform nanoparticles across research sites and excellent control over the physico-chemical parameters.

III. To test pre-clinical activity of formulations with promising in vitro activity with good cell/blood compatibility and to select the best RNA-formulation for clinical translation to treat neurodegenerative diseases. Pre-clinical efficacy is tested after o local injection o nasal administration o systemic administration The neurodegenerative diseases carry a high burden for patients since they are without exception progressive. But they also carry a substantial socio-economic burden with estimated costs of 130 billion euro. per year (2008).

IV. The technical work in B-SMART will be supported by project management. It ensures that the project is coordinated in a clear, unambiguous and mutually acceptable manner and that the project achieves its objectives, within the given financial and time constraints.

in B-SMART we expect to arrive at a scale-able nanoparticle formulation with uniform characteristics that shows strong pre-clinical evidence of therapeutic efficacy and is ready for clinical translation.

Deliverables

List of deliverables.
B-SMART audio-visual material	Websites, patent fillings, videos etc.	2020-02-12 10:13:10
Public project website	Websites, patent fillings, videos etc.	2020-02-12 10:13:10

Take a look to the deliverables list in detail: detailed list of B-SMART deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Helena Sork, Giulia Corso, Kaarel Krjutskov, Henrik J. Johansson, Joel Z. Nordin, Oscar P. B. Wiklander, Yi Xin Fiona Lee, Jakub Orzechowski Westholm, Janne LehtiÃ¶, Matthew J. A. Wood, Imre MÃ¤ger, Samir EL Andaloussi Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28485-9	Scientific Reports 8/1	2020-03-05
2018	Eleni Samaridou Martijn Evers, Pieter Vader, Raymond Schiffelers Evgenia Salta, Hannah Walgrave, Bart De Strooper MarÃa JosÃ© Alonso PEG-PGA Enveloped CPP-RNA nanocomplexes (ENCPs) for the nose-to-brain RNA delivery and treatment of neurodegenerative diseases published pages: , ISSN: , DOI:	2018 Controlled Release Society (CRS) Annual Meeting	2020-03-05
2018	Martijn J. W. Evers, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis, Pieter Vader, Raymond M. Schiffelers State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery published pages: 1700375, ISSN: 2366-9608, DOI: 10.1002/smtd.201700375	Small Methods	2020-02-12
2018	Eduard Willms, Carlos CabaÃ±as, Imre MÃ¤ger, Matthew J. A. Wood, Pieter Vader Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00738	Frontiers in Immunology 9	2020-02-12
2017	Aisling J. Oâ€™Loughlin, Imre MÃ¤ger, Olivier G. de Jong, Miguel A. Varela, Raymond M. Schiffelers, Samir El Andaloussi, Matthew J.A. Wood, Pieter Vader Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles published pages: 1580-1587, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.03.021	Molecular Therapy 25/7	2020-02-12
2018	Eleni Samaridou, Maria JosÃ© Alonso Nose-to-brain peptide delivery â€“ The potential of nanotechnology published pages: 2888-2905, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.11.001	Bioorganic & Medicinal Chemistry 26/10	2020-02-12

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The information about "B-SMART" are provided by the European Opendata Portal: CORDIS opendata.