PREMSOT SIGNED
Precision Multi-Spectral Optoacoustic Tomography for Discovery Diagnosis and Intervention
Total Cost €
0EC-Contrib. €
0Partnership
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Project "PREMSOT" data sheet
The following table provides information about the project.
| Coordinator |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 2˙497˙268 € |
| EC max contribution | 2˙497˙268 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2021-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH | DE (NEUHERBERG) | coordinator | 2˙497˙268.00 |
Map
Project objective
The 2008 ERC Advanced Grant multispectral optoacoustic tomography (MSOT) yielded a novel modality for post-genomic small animal optical imaging, >110 peer-reviewed publications and several major awards including the 2014 Germany’s Innovation award. Since 2011 spin-off iThera Medical GmbH commercialized and placed MSOT systems in European, Asian and North American laboratories, making MSOT an international term. MSOT brought unprecedented optical imaging performance now enabling independent discovery and publications from researchers throughout the world. Compared to other imaging modalities, MSOT uniquely images tissue oxygenation and other vascular and pathophysiology parameters in label-free and portable mode, using safe non-ionizing energy. Therefore, MSOT can impact real-time interventional guidance and longitudinal vascular diagnostics and enable a next level of discovery based on quantitative observations in humans, within the novel requirements of precision and personalized medicine. PREMSOT considers the next steps in the MSOT development and will ⶠdesign and develop label-free portable hybrid MSOT and ultrasound imaging (US) for human use, â· research novel theory and hardware to address remaining MSOT limitations and improve the sensitivity and quantification accuracy, a necessary step for improving MSOT precision, ⸠i) validate quantitative MSOT imaging of tissue oxygenation and hypoxia, (micro)-vascular morphology and function, ii) research label-free imaging of inflammation and metabolism and iii) relate MSOT contrast to tissue and disease pathophysiology metrics and â¹ introduce label-free MSOT/US to discovery and clinical care. MSOT contrast features will be investigated as biomarkers in vascular medicine and surgery and in exploratory measurements within neurology, ambulatory/bedside care or sepsis, addressing unmet discovery and clinical needs.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Nikolaos-Kosmas Chlis, Angelos Karlas, Nikolina-Alexia Fasoula, Michael Kallmayer, Hans-Henning Eckstein, Fabian J Theis, Vasilis Ntziachristos, Carsten Marr A Sparse Deep Learning Approach for Automatic Segmentation of Human Vasculature in Multispectral Optoacoustic Tomography published pages: , ISSN: , DOI: 10.1101/833251 |
bioRxiv doi: https://doi.org/10.1101/83 | 2020-02-28 |
| 2019 |
Maria Anastasopoulou, Dimitris Gorpas, Maximilian Koch, Evangelos Liapis, Sarah Glasl, Uwe Klemm, Angelos Karlas, Tobias Lasser, Vasilis Ntziachristos Fluorescence imaging reversion using spatially variant deconvolution published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-54578-0 |
Scientific Reports 9/1 | 2020-02-28 |
| 2019 |
Miguel A. Pleitez, Asrar Ali Khan, Alice Soldà , Andriy Chmyrov, Josefine Reber, Francesca Gasparin, Markus R. Seeger, Benedikt Schätz, Stephan Herzig, Marcel Scheideler, Vasilis Ntziachristos Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells published pages: , ISSN: 1087-0156, DOI: 10.1038/s41587-019-0359-9 |
Nature Biotechnology | 2020-02-04 |
| 2019 |
Avihai Ron, Xosé LuÃs Deán-Ben, Josephine Reber, Vasilis Ntziachristos, Daniel Razansky Characterization of Brown Adipose Tissue in a Diabetic Mouse Model with Spiral Volumetric Optoacoustic Tomography published pages: 620-625, ISSN: 1536-1632, DOI: 10.1007/s11307-018-1291-y |
Molecular Imaging and Biology 21/4 | 2019-08-29 |
| 2018 |
Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06769-y |
Nature Communications 9/1 | 2019-08-29 |
| 2019 |
B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow Nonâ€invasive imaging in dermatology and the unique potential of rasterâ€scan optoacoustic mesoscopy published pages: 1051-1061, ISSN: 0926-9959, DOI: 10.1111/jdv.15342 |
Journal of the European Academy of Dermatology and Venereology 33/6 | 2019-08-29 |
| 2019 |
Serafeim Moustakidis, Murad Omar, Juan Aguirre, Pouyan Mohajerani, Vasilis Ntziachristos Fully automated identification of skin morphology in rasterâ€scan optoacoustic mesoscopy using artificial intelligence published pages: , ISSN: 0094-2405, DOI: 10.1002/mp.13725 |
Medical Physics | 2019-08-29 |
| 2019 |
Angelos Karlas, Nikolina-Alexia Fasoula, Korbinian Paul-Yuan, Josefine Reber, Michael Kallmayer, Dmitry Bozhko, Markus Seeger, Hans-Henning Eckstein, Moritz Wildgruber, Vasilis Ntziachristos Cardiovascular optoacoustics: From mice to men – A review published pages: 19-30, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2019.03.001 |
Photoacoustics 14 | 2019-08-29 |
| 2019 |
Vasilis Ntziachristos, Miguel A. Pleitez, Silvio Aime, Kevin M. Brindle Emerging Technologies to Image Tissue Metabolism published pages: 518-538, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.09.004 |
Cell Metabolism 29/3 | 2019-08-29 |
| 2019 |
Suhanyaa Nitkunanantharajah, Guillaume Zahnd, Malini Olivo, Nassir Navab, Pouyan Mohajerani, Vasilis Ntziachristos Skin surface detection in 3D optoacoustic mesoscopy based on dynamic programming published pages: 1-1, ISSN: 0278-0062, DOI: 10.1109/tmi.2019.2928393 |
IEEE Transactions on Medical Imaging | 2019-08-29 |
| 2019 |
Juan Aguirre, Andrei Berezhnoi, Hailong He, Mathias Schwarz, Benedikt Hindelang, Murad Omar, Vasilis Ntziachristos Motion Quantification and Automated Correction in Clinical RSOM published pages: 1340-1346, ISSN: 0278-0062, DOI: 10.1109/tmi.2018.2883154 |
IEEE Transactions on Medical Imaging 38/6 | 2019-08-29 |
| 2018 |
Miguel A. Pleitez, Asrar Ali Khan, Josefine Reber, Andriy Chmyrov, Markus R. Seeger, Stephan Herzig, Marcel Scheideler, Vasilis Ntziachristos Mid-infrared optoacoustic microscopy with label-free chemical contrast in living cells and tissues published pages: , ISSN: , DOI: 10.1101/270082 |
bioRxiv February 22, 2018 | 2019-08-29 |
| 2019 |
Vipul Gujrati, Jaya Prakash, Jaber Malekzadeh-Najafabadi, Andre Stiel, Uwe Klemm, Gabriele Mettenleiter, Michaela Aichler, Axel Walch, Vasilis Ntziachristos Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09034-y |
Nature Communications 10/1 | 2019-08-29 |
| 2017 |
Angelos Karlas, Josefine Reber, Gael Diot, Dmitry Bozhko, Maria Anastasopoulou, Tareq Ibrahim, Markus Schwaiger, Fabien Hyafil, Vasilis Ntziachristos Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept published pages: 3395, ISSN: 2156-7085, DOI: 10.1364/boe.8.003395 |
Biomedical Optics Express 8/7 | 2019-06-13 |
| 2018 |
Andrei Berezhnoi, Mathias Schwarz, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy published pages: e201700359, ISSN: 1864-063X, DOI: 10.1002/jbio.201700359 |
Journal of Biophotonics | 2019-06-13 |
| 2018 |
J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy published pages: 31-37, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2018.02.002 |
Photoacoustics 10 | 2019-06-13 |
| 2017 |
Jaya Prakash, Subhamoy Mandal, Daniel Razansky, Vasilis Ntziachristos Maximum entropy based non-negative optoacoustic tomographic image reconstruction published pages: , ISSN: , DOI: |
arXiv:1707.08391 | 2019-06-13 |
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