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GlycoImaging SIGNED

Imaging and detection of tumor-associated glycan structures on tumor cells

Total Cost €

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EC-Contrib. €

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Partnership

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 GlycoImaging project word cloud

Explore the words cloud of the GlycoImaging project. It provides you a very rough idea of what is the project "GlycoImaging" about.

discovery    cancers    interdisciplinary    methanol    columns    technological    diagnostics    skills    glycoconjugates    expression    cancer    scientific    cells    balanced    emphasis    company    entrepreneurial    acid    health    competent    training    biochemistry    microscopy    ing    urine    digital    faster    esrs    assays    fluorescence    imaging    shown    consisting    efficiency    3d    malignant    buffer    neu5gc    solvents    drug    meat    follow    water    accurate    biomedical    spectrum    cell    one    glycans    sa    transformation    sources    exploited    biomarkers    samips    blood    groups    holographic    particle    synthesis    cheaper    metastatic    separation    sialic    detection    laboratories    magnetic    antibodies    neu5ac    incorporated    red    plastic    humans    performed    human    education    packages    biomarker    imprinted    glyco    tissue    quality    polymers    care    forms    mips    glycan    techniques    basis    dietary    phosphate    aggressive    business    molecularly    stage   

Project "GlycoImaging" data sheet

The following table provides information about the project.

Coordinator
MALMO UNIVERSITET 

Organization address
address: NORDENSKIOLDSGATAN 1
city: MALMOE
postcode: 205 06
website: www.mah.se

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Sweden [SE]
 Project website http://glycoimaging.mau.se
 Total cost 2˙138˙720 €
 EC max contribution 2˙138˙720 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MALMO UNIVERSITET SE (MALMOE) coordinator 263˙659.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 580˙163.00
3    BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG DE (BERLIN) participant 498˙432.00
4    TURUN YLIOPISTO FI (Turku) participant 269˙145.00
5    PHASE HOLOGRAPHIC IMAGING PHI AB SE (LUND) participant 263˙659.00
6    UMEA UNIVERSITET SE (UMEA) participant 263˙659.00

Map

 Project objective

The overall objective of Glyco Imaging is to develop novel assays for detection of glycans as biomarkers associated with aggressive and metastatic cancer forms. The assays will be developed for biomarker detection in blood, urine, cells and tissue. Molecularly Imprinted Polymers (MIPs), or plastic antibodies, have been developed for targeting the human glycan sialic acid (SA), or Neu5Ac. The efficiency of the Neu5Ac specific SAMIPs targeted to the biomarker SA in different solvents (methanol, water, phosphate buffer) will be exploited. The non-human Neu5Gc, which is incorporated into human glycoconjugates through dietary sources such as red meat, and shown to be involved in malignant cell transformation in humans, will also be investigated by using highly specific Neu5Gc-SAMIPs. The imaging and detection techniques used will be based on fluorescence, 3D-viewing of cancer cells by digital holographic microscopy and magnetic separation columns. The results in this research consortium will lead to major technological advances having impact on 1) health care, since it will develop more accurate and reliable diagnostics of aggressive and metastatic cancers, 2) drug discovery allowing a faster and cheaper biomarker targeting and detection; and 3) biochemistry research laboratories in resulting in improved understanding of glycan expression in cancer, with emphasis on aggressive metastatic cancer. The training of researchers will be performed by a consortium consisting of 6 partners with biomedical, imaging and particle synthesis skills (4 groups, one institution, one technology company). This forms the basis for a very competent interdisciplinary training program with high quality in both education and research.

8 early stage researchers (ESRs) working on specific tasks within 5 work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.

 Deliverables

List of deliverables.
Produce a minimum of 2 press releases Websites, patent fillings, videos etc. 2020-02-17 15:41:04
Project website launched Websites, patent fillings, videos etc. 2020-02-17 15:41:04
Produce a project poster and a presentation Websites, patent fillings, videos etc. 2020-02-17 15:41:04

Take a look to the deliverables list in detail:  detailed list of GlycoImaging deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Yuecheng Zhang, Kushtrim Llapashtica, Sudhirkumar Shinde, Borje Sellergren, Zahra El-Schich, Anette Gjorloff Wingren
Determination of cytokine regulated glycan expression by using molecularly imprinted polymers targeting sialic acid
published pages: , ISSN: 2454-2857, DOI: 10.20517/2394-4722.2018.112
Journal of Cancer Metastasis and Treatment 2019 2020-02-17
2019 Ville Tähtinen, Alejandra Verhassel, Johanna Tuomela, Pasi Markus Virta
γ‐(S)‐Guanidinylmethyl Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900393
ChemBioChem 2020-02-17
2019 Yoshiki Narimatsu, Hiren J. Joshi, Rebecca Nason, Julie Van Coillie, Richard Karlsson, Lingbo Sun, Zilu Ye, Yen-Hsi Chen, Katrine T. Schjoldager, Catharina Steentoft, Sanae Furukawa, Barbara A. Bensing, Paul M. Sullam, Andrew J. Thompson, James C. Paulson, Christian Büll, Gosse J. Adema, Ulla Mandel, Lars Hansen, Eric Paul Bennett, Ajit Varki, Sergey Y. Vakhrushev, Zhang Yang, Henrik Clausen
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells
published pages: 394-407.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.05.017
Molecular Cell 75/2 2020-02-17
2018 Yen-Hsi Chen, Yoshiki Narimatsu, Thomas M. Clausen, Catarina Gomes, Richard Karlsson, Catharina Steentoft, Charlotte B. Spliid, Tobias Gustavsson, Ali Salanti, Andrea Persson, Anders Malmström, Daniel Willén, Ulf Ellervik, Eric P. Bennett, Yang Mao, Henrik Clausen, Zhang Yang
The GAGOme: a cell-based library of displayed glycosaminoglycans
published pages: 881-888, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0086-z
Nature Methods 15/11 2020-02-17
2019 Louise Sternbæk, Martha Wamaitha Kimani, Kornelia Gawlitza Birgit Janicke, Kersti Alm, and Anette Gjörloff Wingren
Digital holographic cytometry - Macrophage uptake of nanoprobes
published pages: 21-23, ISSN: , DOI:
Imaging&Microscopy 1 2020-02-17

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The information about "GLYCOIMAGING" are provided by the European Opendata Portal: CORDIS opendata.

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