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LungCARD SIGNED

Blood test for clinical therapy guidance of non-small cell lung cancer patients

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LungCARD project word cloud

Explore the words cloud of the LungCARD project. It provides you a very rough idea of what is the project "LungCARD" about.

demonstrated lung cancers detect 30 drug uk worldwide poor weak never network software mutation tki improvement data dna human chemotherapy personalised yield cells confirmation tumour multiplex putting analyser sick circulating reporting treatment samples decision afitinib blood pcr point somatic 75 error technologies training validation hospitals clinical small fp7 laboratories mainly extracted gene cell amplify inhibitor multidisciplinary too integration patients alone global ngs scientists biopsy report cancer chip workflow medicine histological kinase faster frequencies paraffin egfr perform exchange lower biopsies receive proven benefit nsclc pharmacogenomics lungcard automatic microfluidic ctcs capture mutations free sequencing tyrosine ffpe detection fixed quality 20 sanger

Project "LungCARD" data sheet

The following table provides information about the project.

Coordinator	STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA Organization address address: RUA DOS INVENTORES S/N EDIFICIO MADAN PARQUE SALAS 2.18 E 2.19 city: CAPARICA postcode: 2825 182 website: www.stabvida.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	http://www.lungcardrise.eu
Total cost	1˙039˙500 €
EC max contribution	976˙500 € (94%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2016
Funding Scheme	MSCA-RISE
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA Organization address address: RUA DOS INVENTORES S/N EDIFICIO MADAN PARQUE SALAS 2.18 E 2.19 city: CAPARICA postcode: 2825 182 website: www.stabvida.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (CAPARICA)	coordinator	450˙000.00
2	FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS Organization address address: CAMPO GRANDE, EDIFICIO C1, PISO 3 city: LISBON postcode: 1749 016 website: http://www.fciencias-id.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBON)	participant	180˙000.00
3	UNIVERSITY OF HULL UNIVERSITY OF HULL Organization address address: COTTINGHAM ROAD city: HULL postcode: HU6 7RX website: www.hull.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (HULL)	participant	180˙000.00
4	GENOLOGICA MEDICA SL GENOLOGICA MEDICA SL Organization address address: CALLE LARIOS 1-1 IZQUIERDA city: MALAGA postcode: 29000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MALAGA)	participant	85˙500.00
5	UNIWERSYTET JAGIELLONSKI UNIWERSYTET JAGIELLONSKI Organization address address: Ul. Golebia 24 city: KRAKOW postcode: 31007 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (KRAKOW)	participant	40˙500.00
6	GENETIKS SAGLIK HIZMETLERI TICARETLIMITED SIRKETI GENETIKS SAGLIK HIZMETLERI TICARETLIMITED SIRKETI Organization address address: GAYRETTEPE MAH BAHAR SOK BARAS IS MERKEZI NO 4A BALMUMLU BESIKTAS city: ISTANBUL postcode: 34349 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	TR (ISTANBUL)	participant	22˙500.00
7	INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE Organization address address: 14 PASTEROVA ST. city: BELGRADE postcode: 11000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RS (BELGRADE)	participant	18˙000.00
8	FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP Organization address address: CAMPO GRANDE EDIFICIO C1 PISO 3 city: LISBOA postcode: 1749 016 website: http://www.fc.ul.pt/node/654 contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	0.00
9	FEDERAL UNIVERSITY OF AGRICULTURE ABEOKUTA FEDERAL UNIVERSITY OF AGRICULTURE ABEOKUTA Organization address address: ALABATA ROAD OGUN STATE city: ABEOKUTA postcode: 110001 website: www.unaab.edu.ng contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NG (ABEOKUTA)	partner	0.00
10	Institut Pasteur Du Maroc Institut Pasteur Du Maroc Organization address address: Place Louis Pasteur 1 city: Casablanca postcode: 20360 website: www.pasteur.ma contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	MA (Casablanca)	partner	0.00
11	MILLI ONKOLOGIYA MERKEZI MILLI ONKOLOGIYA MERKEZI Organization address address: H. ZERDABI 79B city: BAKU postcode: 1122 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AZ (BAKU)	partner	0.00
12	PARSEQ LAB CO LTD PARSEQ LAB CO LTD Organization address address: BIRZHEVAYA STR 16 city: SAINT PETERSBURG postcode: 199034 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RU (SAINT PETERSBURG)	partner	0.00
13	RESPUBLIKA ONKOLOGIYA ILMIY MARKAZI RESPUBLIKA ONKOLOGIYA ILMIY MARKAZI Organization address address: FAROBIY 383 city: TASKENT postcode: 100174 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UZ (TASKENT)	partner	0.00
14	Sloan-Kettering Institute for Cancer Research CORPORATION Sloan-Kettering Institute for Cancer Research CORPORATION Organization address address: York Avenue 1275 city: New York postcode: 10065 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (New York)	partner	0.00
15	UNIVERSIDAD SAN MARTIN DE PORRES ASOCIACION UNIVERSIDAD SAN MARTIN DE PORRES ASOCIACION Organization address address: AV. LAS CALANDRIAS, SANTA ANITA city: LIMA postcode: 43 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PE (LIMA)	partner	0.00
16	UNIVERSITE HASSAN II DE CASABLANCA UNIVERSITE HASSAN II DE CASABLANCA Organization address address: 19 RUE TARIK IBNOU ZIAD city: CASABLANCA postcode: 20360 website: www.univh2c.ma contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	MA (CASABLANCA)	partner	0.00
17	UNIVERSITY OF TECHNOLOGY SYDNEY UNIVERSITY OF TECHNOLOGY SYDNEY Organization address address: BROADWAY BUILDING 1 ULTIMO NSW city: SYDNEY postcode: 2007 website: http://uts.edu.au/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (SYDNEY)	partner	0.00

Map

Project objective

Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patients with mutation(s) in EGFR gene should receive a EGFR-Tyrosine Kinase Inhibitor (TKI) drug (e.g. afitinib) treatment; while those that do not present mutations in such gene, should be treated with chemotherapy. Currently, the laboratories use PCR and Sanger sequencing technologies to perform the EGFR analysis from tumour biopsies - Fixed Paraffin Embedded (FFPE) samples. Still, some patients (e.g., 30% in UK) may never get histological confirmation because they are too sick to make a biopsy. Furthermore, the results obtained with current methods still present low quality, mainly due to poor quality/low yield of DNA extracted from FFPE samples. The FP7 LungCARD project (www.lungcard.eu) has developed and demonstrated a LungCARD system - an automatic system composed by microfluidic chip and chip analyser - that allows to capture circulating tumour cells (CTCs) from blood samples, amplify by multiplex PCR and detect EGFR mutations, including also a software for data analysis and report. Although this new blood test has proven to be faster, cost-effective and human error-free, the detection of somatic mutations in EGFR gene at frequencies lower than 20% is still a weak point. Therefore, the main project’s goal is to benefit from this technology, through the development, improvement, integration and validation of the LungCARD system with NGS workflow and development of a software for automatic reporting clinical results. However, LungCARD project aims to go further, by putting together a global and unique network of multidisciplinary scientists for exchange of knowledge and research training focused on non-small cell lung cancer.

Deliverables

List of deliverables.
Report on worldwide research and clinical practices related to Lung cancer pharmacogenomics and therapy	Documents, reports	2019-05-30 15:17:14
Mid-term report on outreach activities (including participation in international events, workshops, seminars and publications)	Documents, reports	2019-05-14 14:48:17
Project Website	Websites, patent fillings, videos etc.	2019-05-30 15:32:25

Take a look to the deliverables list in detail: detailed list of LungCARD deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Radmila Jankovic1 , Helena J. Goncalves2 , Milena Cavic1 , Carla Clemente2 , Michael Lind3 , Alexis Murillo Carrasco4 , Selama Nadifi5 , Meriem Khyatti6 , Tumininu Adebambo7 , Dilshod Egamberdiev8 1 Institute for Oncology and Radiology of Serbia, Belgrade, Serbia; 2 StabVida, Caparica, Portugal; 3 University of HULL, UK; 4 Centro de GenÃ©tica y BiologÃa Molecular, Facultad de Medicina Humana, Universidad de San MartÃn de Porres, Lima, Peru; 5 Universite Hassan II de Casablanca, Morocco; 6 Institut Pasteur Du Maroc, Morocco; 7 Federal University of Agriculture, Nigeria; 8 National Cancer Center of Uzbekistan, Uzbekistan. LungCARD - Report on worldwide research and clinical practices related to lung cancer published pages: , ISSN: 1107-0625, DOI:	JBUON Open Access Journal aimed at the rapid diffusion of scientific knowledge in Oncology.	2019-05-14

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The information about "LUNGCARD" are provided by the European Opendata Portal: CORDIS opendata.