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THZCALORIMETRY SIGNED

Time Resolved THz Calorimetry explores Molecular Recognition Processes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

THZCALORIMETRY project word cloud

Explore the words cloud of the THZCALORIMETRY project. It provides you a very rough idea of what is the project "THZCALORIMETRY" about.

delta recognition quantitative protein resolution introduce ultrafast cutting mu substrates enthalpy transient deriving effect deduce equilibrium detection underlying scientific definition molecular accompanying nsec envisioned samples mmp enzyme correlate explore spectra density vision innovative sec separation specify reactions mechanisms biological ligand resolutions calorimetry experimental purpose 10w time resolved thz experimentally edge tool ambient science 300cm models enzymatic function sources predictive family biomolecular solvent explores measuring monitor modes hydrophobic enzymes kinetics frequency entropy nanoseconds

Project "THZCALORIMETRY" data sheet

The following table provides information about the project.

Coordinator	RUHR-UNIVERSITAET BOCHUM Organization address address: UNIVERSITAETSSTRASSE 150 city: BOCHUM postcode: 44801 website: www.rub.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	2˙500˙000 €
EC max contribution	2˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RUHR-UNIVERSITAET BOCHUM RUHR-UNIVERSITAET BOCHUM Organization address address: UNIVERSITAETSSTRASSE 150 city: BOCHUM postcode: 44801 website: www.rub.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BOCHUM)	coordinator	2˙100˙000.00
2	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	400˙000.00

Map

Project objective

Time-resolved THz-Calorimetry Explores Molecular Recognition Processes

Definition: “THz-calorimetry is the science of measuring low frequency density of states kinetics for the purpose of deriving the entropy changes associated with biological processes in real time.”

Goal: Our scientific vision is to introduce time-resolved “THz-Calorimetry” to access the entropy changes of the protein and the solvent accompanying enzymatic reactions or more general molecular recognition processes, i.e. under non-equilibrium conditions with envisioned time resolutions of nanoseconds. Advances in THz technology will make it possible to develop strong, ultrafast THz sources in the frequency range up to 10W that allow the detection of frequency-resolved transient low frequency spectra of biological samples with μsec or even nsec time resolution. We will correlate the transient THz spectra with changes in the entropy and enthalpy, both experimentally and theoretically. Ultrafast THz-calorimetry is an innovative tool to access to the specific transient entropy changes of molecular recognition processes under non-equilibrium conditions.

Objectives of the proposal: 1. Monitor transient low frequency spectra (0-300cm-1) during molecular recognition processes. 2. Develop cutting edge experimental methods which allow the separation of protein and solvent modes under ambient conditions. Determine Delta S(protein(t)), Delta S(ligand(t)), Delta S(solvent(t)), thus specify the role of changes in the solvent entropy (hydrophobic effect) for biomolecular recognition. 3. Apply ultrafast THz-calorimetry: Explore the entropy changes of the enzyme, the ligand and the solvent for a family of MMP enzymes and substrates and correlate these results with biological function. Deduce underlying molecular mechanisms. 4. Develop new models for molecular recognition processes which are quantitative and predictive.

Publications

List of publications.
year	authors and title	journal	last update
2017	Elena Decaneto, Tatiana Vasilevskaya, Yuri Kutin, Hideaki Ogata, Moran Grossman, Irit Sagi, Martina Havenith, Wolfgang Lubitz, Walter Thiel, Nicholas Cox Solvent water interactions within the active site of the membrane type I matrix metalloproteinase published pages: 30316-30331, ISSN: 1463-9076, DOI: 10.1039/c7cp05572b	Physical Chemistry Chemical Physics 19/45	2019-06-13
2017	Viren Pattni, Tatiana Vasilevskaya, Walter Thiel, Matthias Heyden Distinct Protein Hydration Water Species Defined by Spatially Resolved Spectra of Intermolecular Vibrations published pages: 7431-7442, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.7b03966	The Journal of Physical Chemistry B 121/31	2019-06-13
2016	Dalit Talmi-Frank, Zeev Altboum, Inna Solomonov, Yael Udi, DiegoÂ Adhemar Jaitin, Mordehay Klepfish, Eyal David, Alina Zhuravlev, Hadas Keren-Shaul, DeborahÂ R. Winter, Irit Gat-Viks, Michal Mandelboim, Tamar Ziv, Ido Amit, Irit Sagi Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality published pages: 458-470, ISSN: 1931-3128, DOI: 10.1016/j.chom.2016.09.005	Cell Host & Microbe 20/4	2019-06-13
2017	Katsuyoshi Aoki, Janne Savolainen, Martina Havenith Broadband terahertz pulse generation by optical rectification in GaP crystals published pages: 201103, ISSN: 0003-6951, DOI: 10.1063/1.4983371	Applied Physics Letters 110/20	2019-06-13
2017	Rasmus A. X. Persson, Viren Pattni, Anurag Singh, Stefan M. Kast, Matthias Heyden Signatures of Solvation Thermodynamics in Spectra of Intermolecular Vibrations published pages: 4467-4481, ISSN: 1549-9618, DOI: 10.1021/acs.jctc.7b00184	Journal of Chemical Theory and Computation 13/9	2019-06-13
2017	Valeria Conti Nibali, Giulia Morra, Martina Havenith, Giorgio Colombo Role of Terahertz (THz) Fluctuations in the Allosteric Properties of the PDZ Domains published pages: 10200-10208, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.7b06590	The Journal of Physical Chemistry B 121/44	2019-06-13
2017	Fabian BÃ¶hm, Gerhard Schwaab, Martina Havenith Mapping Hydration Water around Alcohol Chains by THz Calorimetry published pages: 9981-9985, ISSN: 1433-7851, DOI: 10.1002/anie.201612162	Angewandte Chemie International Edition 56/33	2019-06-13
2019	C. Hoberg, P. Balzerowski, M. Havenith Integration of a rapid scanning technique into THz time-domain spectrometers for nonlinear THz spectroscopy measurements published pages: 35348, ISSN: 2158-3226, DOI: 10.1063/1.5080653	AIP Advances 9/3	2019-06-05

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