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PIMS SIGNED

Mechanistic studies of long chain omega-3 fatty acid supplementation and inflammation in metabolic syndrome.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PIMS project word cloud

Explore the words cloud of the PIMS project. It provides you a very rough idea of what is the project "PIMS" about.

attenuate suggests adipose vivo systemic biomarkers lcn polyunsaturated crossover mechanisms chain markers cardiovascular inflammation sex body fatty lifestyle mediators women mixture data guide derivatives treatment men acid levels diet efficacy compare justification docosahexaenoic modalities stress humans isotopes professionals syndrome blind kinetics policy health tissue subclinical pro stable lipid quantifying inflammatory supplementation randomized dietary unclear strategies oxygenated extremely causes prevention influenced metabolic molecular date dha innovative primarily diseases anti epa gender prevalent oxidative mets obesity omega 3pufa makers literature plasma differences eicosapentaenoic unknown placebo acids double

Project "PIMS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE LYON 1 CLAUDE BERNARD Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 website: www.univ-Iyon1.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	232˙160 €
EC max contribution	232˙160 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-GF
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2020-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE LYON 1 CLAUDE BERNARD UNIVERSITE LYON 1 CLAUDE BERNARD Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 website: www.univ-Iyon1.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEURBANNE CEDEX)	coordinator	232˙160.00
2	UNIVERSITE LAVAL UNIVERSITE LAVAL Organization address address: ALLEE DES BIBLIOTHEQUES 2345 city: QUEBEC postcode: G1V 0A6 website: http://www.ulaval.ca contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CA (QUEBEC)	partner	0.00

Map

Project objective

Subclinical inflammation is a key factor in the development of cardiovascular diseases. Obesity and metabolic syndrome (MetS), both diet and lifestyle-related, are highly prevalent causes of subclinical inflammation. A growing body of literature suggests that dietary long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) may attenuate MetS-associated pro-inflammatory state. However, it remains unclear whether the different LCn-3PUFA, primarily docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have similar effects on pro-inflammatory processes because most previous studies used them in mixture. Whether efficacy of LCn-3PUFA is influenced by sex/gender is also unknown. The objective of the proposed research is thus to compare the anti-inflammatory effects of EPA and DHA in humans with MetS through very innovative kinetics and molecular studies. We will compare in a double-blind, crossover randomized placebo-controlled study in men and women with MetS (i) the impact of EPA and DHA supplementation on the plasma in vivo kinetics of inflammatory biomarkers using stable isotopes and (ii) the anti-inflammatory molecular mechanisms of EPA and DHA at both adipose tissue and systemic levels. The role of lipid mediators specific to EPA and DHA in this process will be addressed by quantifying (i) oxygenated derivatives from EPA and DHA in plasma, (ii) their molecular targets in adipose tissue and (iii) markers of oxidative stress in plasma. The proposed research shall be one of the most comprehensive studies comparing the impact of EPA and DHA on both systemic and adipose tissue-specific subclinical inflammation to date. The in-depth understanding of their effects and possible gender differences will be extremely novel. Such data will provide much needed evidence-based justification for the use of specific dietary treatment modalities in men and women with MetS, which can further guide policy makers and health professionals for potential prevention strategies.

Publications

List of publications.
year	authors and title	journal	last update
2017	CÃ©cile Vors, Janie Allaire, Johanne Marin, Marie-Claude LÃ©pine, AmÃ©lie Charest, AndrÃ© Tchernof, Patrick Couture, BenoÃ®t Lamarche Inflammatory gene expression in whole blood cells after EPA vs. DHA supplementation: Results from the ComparED study published pages: 116-122, ISSN: 0021-9150, DOI: 10.1016/j.atherosclerosis.2017.01.025	Atherosclerosis 257	2019-08-06

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