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PRIMASKOTI

PReparing Introduction to MArket of SKOTI (PRIMASKOTI) - a breakthrough solution for real-time studies of cytoskeletal motors at single-molecule resolution

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 PRIMASKOTI project word cloud

Explore the words cloud of the PRIMASKOTI project. It provides you a very rough idea of what is the project "PRIMASKOTI" about.

prepare    skoti    commercialize    optical    glass    primaskoti    minimize    interactions    solid    instruments    swiss    force    operate    solution    isolation    operation    preparation    protein    flexibility    medical    microscopy    molecular    environment    contracts    engage    life    unprecedented    combines    specialized    throughput    cell    cutting    platform    molecule    imaging    knife    designed    ultra    scientific    biomolecules    strengths    requirement    cancer    mechanical    edge    software    difficult    commercially    modular    probes    idea    kits    contact    hardly    experiments    diseases    techniques    manipulation    pave    stability    sciences    resolution    times    instrument    service    cytoskeletal    surface    neurodegeneration    transport    tweezers    lower    displacement    broaden    complete    machines    automatization    division    tool    cellular    commercializing    scope    supplemented    simplify    commercialization    microscope    barriers    ease    motorization    single    motor    requiring   

Project "PRIMASKOTI" data sheet

The following table provides information about the project.

Coordinator
EBERHARD KARLS UNIVERSITAET TUEBINGEN 

Organization address
address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074
website: www.uni-tuebingen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 149˙238 €
 EC max contribution 149˙238 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) coordinator 149˙238.00

Map

 Project objective

The PRIMASKOTI project will prepare the commercialization of SKOTI—the Swiss Knife for Optical Tweezers and Imaging. The scientific instrument SKOTI is designed to measure interactions between single biomolecules with a focus on cytoskeletal molecular machines. SKOTI combines several state-of-the-art microscopy techniques with contact-less mechanical manipulation, so-called optical tweezers. Because of its ultra high stability, SKOTI has its particular strengths in experiments requiring a solid support such as a glass surface. This requirement is often the case for cytoskeletal motor protein studies. Since these molecular machines are key to many essential cellular processes such as transport or cell division, being able to study their interactions is an important step towards understanding diseases such as cancer or neurodegeneration. However, due to the highly specialized knowledge necessary to build and operate such instruments, hardly commercially available, single-molecule experiments are difficult. By commercializing SKOTI, we aim to provide a simple-to-access tool which will broaden the scope of applications and users. SKOTI will provide a modular microscope and optical manipulation platform with unprecedented force- and displacement-resolution, ease of operation through motorization and automatization, flexibility, and overall stability of the system. The key idea is to commercialize a complete solution, where the instrument is supplemented with an isolation from the environment, operation and analysis software, specialized probes, service contracts, and kits for experiments that help to minimize preparation times. This approach will simplify single-molecule experiments, increase throughput, and lower barriers to engage in such studies. In the long term, our novel, cutting-edge research tool for life sciences will provide insight to essential cellular processes and pave the way for new medical approaches.

 Publications

year authors and title journal last update
List of publications.
2019 Gero L. Hermsdorf, Sven A. Szilagyi, Sebastian Rösch, Erik Schäffer
High performance passive vibration isolation system for optical tables using six-degree-of-freedom viscous damping combined with steel springs
published pages: 15113, ISSN: 0034-6748, DOI: 10.1063/1.5060707
Review of Scientific Instruments 90/1 2020-01-27

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