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HOST-SELECT SIGNED

Functional Analysis of Host Genetic Variants: Biomarker Selection Towards Improving Female Subfertility Diagnosis and Treatment

Total Cost €

EC-Contrib. €

Partnership

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HOST-SELECT project word cloud

Explore the words cloud of the HOST-SELECT project. It provides you a very rough idea of what is the project "HOST-SELECT" about.

diagnosis model certain roughly course reducing infection trying examinations trachomatis lastly makeup crispr woman cas9 assay vivo tubes elucidated 15 subfertility first invasive learning organoid host infected conceive diagnostic burdening suffer pathology human fallopian referrals suboptimal silencing introduce function genetic ct mutations genes pathogenesis optimally gene expertise persistent tp single 13 surgical techniques chlamydia plan group cutting found pathologies analysing disseminating editing interference rna conducting edge network tubal simulates couples experts functional women causes variants costly health effect tube underlying exact successfully public risk offers

Project "HOST-SELECT" data sheet

The following table provides information about the project.

Coordinator	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: Munich postcode: 80539 website: www.mpg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	159˙460 €
EC max contribution	159˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: Munich postcode: 80539 website: www.mpg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Munich)	coordinator	159˙460.00

Map

Project objective

Roughly 15% of couples trying to conceive suffer from subfertility. One of its leading causes is developed pathology in woman’s fallopian tubes (tubal pathology or TP). Persistent infection with Chlamydia trachomatis (CT) is the single most common cause of TP. Women with a certain genetic makeup are more likely to develop TP after CT infection. I have so far identified 8 host genes and 13 genetic variants associated with CT infection and TP. Their exact function is, however, not yet elucidated. In this project, I will research the effect of found host genetic factors on CT infection and TP, by analysing their function in a human fallopian tube organoid model. This model optimally simulates in vivo conditions in the tubes. The host institution offers the technology and expertise for conducting such research. The analysis will be achieved via RNA interference gene-silencing technology, successfully applied by the host group in their CT research for years. I will then introduce targeted mutations via CRISPR/Cas9 gene-editing assay and study the effect on the course of the infection. Lastly, I will determine the network of involved gene pathways in order to explain the underlying pathogenesis. This will be the first ever functional analysis of host factors associated with CT infection and TP in an organoid. The analyses will require learning and applying cutting-edge techniques (RNA interference and CRISPR/Cas9). Also, it will be the first delivery of specific, targeted mutations into a CT-infected organoid and first such study of their effect on developing pathologies. Achieving these objectives will facilitate the development of a novel diagnostic assay in order to address an existing health need - improving the currently suboptimal diagnosis of women at risk of CT-associated TP and reducing referrals to invasive, burdening and costly surgical examinations. I have also developed a detailed plan for disseminating the findings to experts and general public.

Publications

List of publications.
year	authors and title	journal	last update
2018	Brankovic I, Malogajski J, Land JA, Morre SA, Ambrosino E. POTENTIAL OF CHLAMYDIA TRACHOMATIS HOST GENETIC PROFILING TO MODIFY THE SCREENING FOR TUBAL FACTOR INFERTILITY (TFI) â€“ THE DUTCH PERSPECTIVE published pages: , ISSN: , DOI:	Proceedings of the Fourteenth International Symposium of Human Chlamydial Infections 6. July 2018.	2019-09-05
2019	Jelena Malogajski, Ivan BrankoviÄ‡, Jolande A. Land, Pierre P. M. Thomas, Servaas A. MorrÃ©, Elena Ambrosino The Potential Role for Host Genetic Profiling in Screening for Chlamydia-Associated Tubal Factor Infertility (TFI)â€”New Perspectives published pages: 410, ISSN: 2073-4425, DOI: 10.3390/genes10060410	Genes 10/6	2019-09-05

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